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We present a three-stage framework for training deep learning models specializing in antibody sequence-structure co-design. We first pre-train a language model using millions of antibody sequence data. Then, we employ the learned…

Machine Learning · Computer Science 2025-10-24 Yibo Wen , Chenwei Xu , Jerry Yao-Chieh Hu , Kaize Ding , Han Liu

We provide a methodology, resilient feature engineering, for creating adversarially resilient classifiers. According to existing work, adversarial attacks identify weakly correlated or non-predictive features learned by the classifier…

Machine Learning · Computer Science 2018-12-18 Kevin Eykholt , Atul Prakash

Mathematical models of natural and man-made systems often have many adjustable parameters that must be estimated from multiple, potentially conflicting datasets. Rather than reporting a single best-fit parameter vector, it is often more…

Quantitative Methods · Quantitative Biology 2026-04-01 Jeffrey D. Varner

This work presents a scalable computational framework for optimal design under uncertainty with application to multi-material insulation components of building envelopes. The forward model consists of a multi-phase thermo-mechanical model…

Optimization and Control · Mathematics 2023-04-20 Jingye Tan , Danial Faghihi

The evaluation of fairness models in Machine Learning involves complex challenges, such as defining appropriate metrics, balancing trade-offs between utility and fairness, and there are still gaps in this stage. This work presents a novel…

Machine Learning · Computer Science 2026-03-03 Gökhan Özbulak , Oscar Jimenez-del-Toro , Maíra Fatoretto , Lilian Berton , André Anjos

We propose a theoretical approach for calculating effective electric and magnetic properties of composites with field-dependent restructuring of the filler. The theory combines the Bruggeman-Landauer approximation extended to a…

Materials Science · Physics 2019-10-02 Andrei Snarskii , Denis Zorinets , Mikhail Shamonin , Viktor Kalita

A density-functional-theory based approach to efficiently compute numerically exact vibrational free energies - including anharmonicity - for chemically complex multicomponent alloys is developed. It is based on a combination of…

Adhesive attachment systems consisting of multiple tapes or strands are commonly found in nature, for example in spider web anchorages or in mussel byssal threads, and their structure has been found to be ingeniously architected in order to…

Classical Physics · Physics 2019-06-27 Lucas Brely , Federico Bosia , Ali Dhinojwala , Nicola M. Pugno

High-entropy materials have attracted considerable interest due to the combination of useful properties and promising applications. Predicting their formation remains the major hindrance to the discovery of new systems. Here we propose a…

We use inverse methods of statistical mechanics to explore trade-offs associated with designing interactions to stabilize self-assembled structures against changes in density or temperature. Specifically, we find isotropic,convex-repulsive…

Soft Condensed Matter · Physics 2018-01-10 William D. Piñeros , Michael Baldea , Thomas M. Truskett

Multi-objective evaluation is a necessary aspect when managing complex systems, as the intrinsic complexity of a system is generally closely linked to the potential number of optimization objectives. However, an evaluation makes no sense…

Physics and Society · Physics 2016-08-03 Juste Raimbault

High entropy materials, which include high entropy alloys, carbides, and borides, are a topic of substantial research interest due to the possibility of a large number of new material compositions that could fill gaps in application needs.…

Materials Science · Physics 2020-07-16 Lavina Backman , Joshua Gild , Jian Luo , Elizabeth J. Opila

In this study, we evaluate several classifiers and focus on selecting a minimal set of appropriate material features. Our objective is to propose and discuss general strategies for reducing the number of descriptors required for material…

Other Condensed Matter · Physics 2025-10-01 Giovanni Trezza , Eliodoro Chiavazzo

We develop the \textit{a posteriori} error analysis of three mixed finite element formulations for rotation-based equations in elasticity, poroelasticity, and interfacial elasticity-poroelasticity. The discretisations use $H^1$-conforming…

Numerical Analysis · Mathematics 2021-06-18 VerÓnica Anaya , Arbaz Khan , David Mora , Ricardo Ruiz-Baier

We have developed an efficient and reliable methodology for crystal structure prediction, merging ab initio total-energy calculations and a specifically devised evolutionary algorithm. This method allows one to predict the most stable…

Materials Science · Physics 2009-11-18 A. R. Oganov , C. W. Glass

We investigate one-dimensional harmonically trapped two-component systems for repulsive interaction strengths ranging from the non-interacting to the strongly interacting regime for Fermi-Fermi mixtures. A new and powerful mapping between…

Quantum Gases · Physics 2017-02-17 F. F. Bellotti , A. S. Dehkharghani , N. T. Zinner

Equilibrium structures determine material properties and biochemical functions. We propose to machine learn phase-space averages, conventionally obtained by {\em ab initio} or force-field based molecular dynamics (MD) or Monte Carlo…

Chemical Physics · Physics 2022-07-27 Jan Weinreich , Dominik Lemm , Guido Falk von Rudorff , O. Anatole von Lilienfeld

We develop a fast and scalable computational framework to solve large-scale and high-dimensional Bayesian optimal experimental design problems. In particular, we consider the problem of optimal observation sensor placement for Bayesian…

Numerical Analysis · Mathematics 2020-11-09 Keyi Wu , Peng Chen , Omar Ghattas

Ensuring fairness in machine learning models is critical, especially when biases compound across intersecting protected attributes like race, gender, and age. While existing methods address fairness for single attributes, they fail to…

Machine Learning · Computer Science 2025-09-24 Priyobrata Mondal , Faizanuddin Ansari , Swagatam Das

We demonstrate the development of a series of refractory high-entropy alloys containing aluminum AlRHEAs in the ordered BCC-B2 phase by varying the aluminum content within 10 to 25 atomic percent, with the goal of high strength and good…

Materials Science · Physics 2024-02-27 Jie Qi , Xuesong Fan , Diego Ibarra Hoyos , Peter K. Liaw , S. Joseph Poon