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We study quantum coarse-grained entropy and demonstrate that the gap in entropy between local and global coarse-grainings is a natural generalization of entanglement entropy to mixed states and multipartite systems. This "quantum…

Quantum Physics · Physics 2020-12-02 Joseph Schindler , Dominik Šafránek , Anthony Aguirre

Incorporating atomistic and molecular information into models of cellular behaviour is challenging because of a vast separation of spatial and temporal scales between processes happening at the atomic and cellular levels. Multiscale or…

Computational Physics · Physics 2019-08-28 Radek Erban

In computational materials science, coarse-graining approaches often lack a priori uncertainty quantification (UQ) tools that estimate the accuracy of a reduced-order model before it is calibrated or deployed. This is especially the case in…

Computational Physics · Physics 2018-12-11 Paul N. Patrone , Andrew M. Dienstfrey , Geoffrey B. McFadden

Enhanced sampling methods typically require predefined collective variables (CVs) that presuppose knowledge of reaction coordinates, restricting the discovery of unanticipated transition mechanisms or intermediates. Here, we show that a…

Chemical Physics · Physics 2026-04-08 Xiangrui Li , Daniel Schwalbe-Koda

A versatile and transferable coarse-grained (CG) model was developed to investigate the self-assembly of two ubiquitous methacrylate-based copolymers: poly(ethylene oxide-b-methylmethacrylate) (PEO-b-PMMA) and poly(ethylene…

Soft Condensed Matter · Physics 2018-05-29 Gerardo Campos-Villalobos , Flor R. Siperstein , Alessandro Patti

A first-principles based methodology for efficiently and accurately finding thermodynamically stable and metastable atomic structures is introduced and benchmarked. The approach is demonstrated for gas-phase metal-oxide clusters in…

A microscopic understanding of low-temperature thermodynamics and its relation to dynamical features such as a fragile-to-strong crossover (FSC) remains a central challenge in glass physics. Using swap Monte Carlo combined with a full…

Soft Condensed Matter · Physics 2026-05-25 Anshul D. S. Parmar , Simon G. Kellers , Andreas Heuer

We extend the analysis of the thermodynamics of the climate system by investigating the role played by processes taking place at various spatial and temporal scales through a procedure of coarse graining. The coarser is the graining of the…

Statistical Mechanics · Physics 2015-06-15 Valerio Lucarini , Salvatore Pascale

The present work concerns the transferability of coarse-grained (CG) modeling in reproducing the dynamic properties of the reference atomistic systems across a range of parameters. In particular, we focus on implicit-solvent CG modeling of…

Computational Engineering, Finance, and Science · Computer Science 2021-03-22 Zhan Ma , Shu Wang , Minhee Kim , Kaibo Liu , Chun-Long Chen , Wenxiao Pan

The physical foundations of a variety of emerging technologies --- ranging from the applications of quantum entanglement in quantum information to the applications of nonequilibrium bulk and interface phenomena in microfluidics, biology,…

Quantum Physics · Physics 2014-03-25 Gian Paolo Beretta , Enzo Zanchini

In this study, we advance the understanding of non-equilibrium systems by deriving thermodynamic relations for a heat engine operating under an exponentially decreasing temperature profile. Such thermal configurations closely mimic…

Statistical Mechanics · Physics 2025-04-01 Mesfin Taye

It is known that statistical model selection as well as identification of dynamical equations from available data are both very challenging tasks. Physical systems behave according to their underlying dynamical equations which, in turn, can…

Mathematical Physics · Physics 2017-10-11 Sean Alan Ali , Carlo Cafaro

Machine learning (ML) offers considerable promise for the design of new molecules and materials. In real-world applications, the design problem is often domain-specific, and suffers from insufficient data, particularly labeled data, for ML…

Chemical Physics · Physics 2025-02-04 Ming Han , Ge Sun , Juan J. de Pablo

We propose the first, to our knowledge, coarse-grained modeling strategy for peptides where the effect of changes of the pH can be efficiently described. The idea is based on modeling the effects of the pH value on the main driving…

Biological Physics · Physics 2013-04-29 Marta Enciso , Christof Schuette , Luigi Delle Site

In the present article, novel Coarse-Graining (CG) algorithms for the Eulerian-Lagrangian (EL) simulation of particle-laden flows are proposed. These include different variants of Reproducing Kernel Particle Methods (RKPM) and an extended…

Fluid Dynamics · Physics 2025-11-12 H. Eshraghi , E. Amani , M. Saffar-Avval

We present a novel thermodynamically guided, low-noise, time-scale bridging, and pertinently efficient strategy for the dynamic simulation of microscopic models for complex fluids. The systematic coarse-graining method is exemplified for…

Soft Condensed Matter · Physics 2010-11-12 Patrick Ilg , Hans Christian Öttinger , Martin Kröger

Grain boundaries (GBs) can critically influence the microstructural evolution and various materials properties. However, a fundamental understanding of GBs in high-entropy alloys (HEAs) is lacking because of the complex couplings of the…

Materials Science · Physics 2021-04-13 Chongze Hu , Jian Luo

Entropy alone can self-assemble hard particles into colloidal crystals of remarkable complexity whose structures are the same as atomic and molecular crystals, but with larger lattice spacings. Although particle-based molecular simulation…

Soft Condensed Matter · Physics 2021-07-06 Thi Vo , Sharon C. Glotzer

We present a new computational framework combining coarse-graining techniques with bootstrap methods to study quantum many-body systems. The method efficiently computes rigorous upper and lower bounds on both zero- and finite-temperature…

High Energy Physics - Theory · Physics 2025-11-25 Minjae Cho , Colin Oscar Nancarrow , Petar Tadić , Yuan Xin , Zechuan Zheng

Recently, some of us developed a novel model glass-forming liquid with k extra interactions with pseudo neighbours to each liquid particle over and above the regular interactions with its neighbours. Analysis of the structure and dynamics…

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