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Uncertainty in the estimation of the causal effect in observational studies is often due to unmeasured confounding, i.e., the presence of unobserved covariates linking treatments and outcomes. Instrumental Variables (IV) are commonly used…

Methodology · Statistics 2019-07-30 M. Usaid Awan , Yameng Liu , Marco Morucci , Sudeepa Roy , Cynthia Rudin , Alexander Volfovsky

In observational studies, potential unobserved confounding is a major barrier in isolating the average causal effect (ACE). In these scenarios, two main approaches are often used: confounder adjustment for causality (CAC) and instrumental…

Methodology · Statistics 2024-11-26 Roy S. Zawadzki , Daniel L. Gillen

Scientists regularly pose questions about treatment effects on outcomes conditional on a post-treatment event. However, causal inference in such settings requires care, even in perfectly executed randomized experiments. Recently, the…

Methodology · Statistics 2026-02-19 Chan Park , Mats Stensrud , Eric Tchetgen Tchetgen

Instrumental variables are widely used in econometrics and epidemiology for identifying and estimating causal effects when an exposure of interest is confounded by unmeasured factors. Despite this popularity, the assumptions invoked to…

Methodology · Statistics 2024-02-15 Alexander W. Levis , Edward H. Kennedy , Luke Keele

Causal inference with spatial environmental data is often challenging due to the presence of interference: outcomes for observational units depend on some combination of local and non-local treatment. This is especially relevant when…

Applications · Statistics 2024-05-15 Nathan B. Wikle , Corwin M. Zigler

One obstacle to ``elevating" correlation to causation is the phenomenon of confounding, i.e., when a correlation between two variables exists because both variables are in fact caused by a third variable. The situation where the confounders…

Applications · Statistics 2025-06-24 Caren Marzban , Yikun Zhang , Nicholas Bond , Michael Richman

Consider the problem of estimating the causal effect of some attribute of a text document; for example: what effect does writing a polite vs. rude email have on response time? To estimate a causal effect from observational data, we need to…

Machine Learning · Statistics 2023-02-09 Lin Gui , Victor Veitch

Proximal causal inference (PCI) has emerged as a promising framework for identifying and estimating causal effects in the presence of unobserved confounders. While many traditional causal inference methods rely on the assumption of no…

Understanding and quantifying cause and effect is an important problem in many domains. The generally-agreed solution to this problem is to perform a randomised controlled trial. However, even when randomised controlled trials can be…

Machine Learning · Statistics 2023-02-22 Graham Van Goffrier , Lucas Maystre , Ciarán Gilligan-Lee

In experimental and observational data settings, researchers often have limited knowledge of the reasons for missing outcomes. To address this uncertainty, we propose bounds on causal effects for missing outcomes, accommodating the scenario…

Methodology · Statistics 2026-03-19 Max Rubinstein , Denis Agniel , Larry Han , Marcela Horvitz-Lennon , Sharon-Lise Normand

Understanding the effects of interventions is central to scientific progress, with randomized controlled trials (RCTs) regarded as the gold standard for causal inference in many applied fields. However, RCTs are costly, time-consuming, and…

Methodology · Statistics 2026-05-27 Drago Plecko , Patrik Okanovic , Torsten Hoefler , Elias Bareinboim

We propose novel methods for predictive (sparse) PCA with spatially misaligned data. These methods identify principal component loading vectors that explain as much variability in the observed data as possible, while also ensuring the…

Methodology · Statistics 2015-09-04 Roman A. Jandarov , Lianne A. Sheppard , Paul D. Sampson , Adam A. Szpiro

Emissions generators, such as coal-fired power plants, are key contributors to air pollution and thus environmental policies to reduce their emissions have been proposed. Furthermore, marginalized groups are exposed to disproportionately…

Methodology · Statistics 2024-01-26 Kevin L. Chen , Falco J. Bargagli Stoffi , Raphael C. Kim , Rachel C. Nethery

Per- and polyfluoroalkyl substances (PFAS) are typically encountered as mixtures of distinct chemicals with distinct effects on multiple health outcomes. Estimating joint causal effects using spatially-dependent observed data is…

Methodology · Statistics 2026-03-18 Xiaodan Zhou , Brian J Reich , Shu Yang

In epidemiological studies of air pollution and public health, estimating the health impact of exposure to air pollution may be hindered by the unknown functional form of the exposure-outcome association and by unmeasured confounding…

Methodology · Statistics 2026-01-28 Carlo Zaccardi , Pasquale Valentini , Luigi Ippoliti , Alexandra M. Schmidt

In some causal inference scenarios, the treatment variable is measured inaccurately, for instance in epidemiology or econometrics. Failure to correct for the effect of this measurement error can lead to biased causal effect estimates.…

Machine Learning · Computer Science 2024-09-13 Antti Pöllänen , Pekka Marttinen

Convenient access to observational data enables us to learn causal effects without randomized experiments. This research direction draws increasing attention in research areas such as economics, healthcare, and education. For example, we…

Social and Information Networks · Computer Science 2019-12-03 Ruocheng Guo , Jundong Li , Huan Liu

Consider sensitivity analysis for estimating average treatment effects under unmeasured confounding, assumed to satisfy a marginal sensitivity model. At the population level, we provide new representations for the sharp population bounds…

Methodology · Statistics 2022-09-26 Zhiqiang Tan

Causal mediation analysis is complicated with multiple effect definitions that require different sets of assumptions for identification. This paper provides a systematic explanation of such assumptions. We define five potential outcome…

Methodology · Statistics 2022-09-26 Trang Quynh Nguyen , Ian Schmid , Elizabeth L. Ogburn , Elizabeth A. Stuart

This study develops a Bayesian hierarchical model to explore the effects of air pollution on respiratory and cardiovascular mortality in Los Angeles County. The model takes into account various pollutants such as PM2.5, PM10, CO, SO2, NO2…

Applications · Statistics 2025-01-29 Yanfei Qu , David A. Stephens
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