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Over the past years, pseudo-healthy reconstruction for unsupervised anomaly detection has gained in popularity. This approach has the great advantage of not requiring tedious pixel-wise data annotation and offers possibility to generalize…

Image and Video Processing · Electrical Eng. & Systems 2024-01-30 Ravi Hassanaly , Camille Brianceau , Maëlys Solal , Olivier Colliot , Ninon Burgos

Unsupervised anomaly detection (UAD) plays a crucial role in neuroimaging for identifying deviations from healthy subject data and thus facilitating the diagnosis of neurological disorders. In this work, we focus on Bayesian flow networks…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Hugues Roy , Reuben Dorent , Ninon Burgos

Anomaly detection (AD) is the identification of data samples that do not fit a learned data distribution. As such, AD systems can help physicians to determine the presence, severity, and extension of a pathology. Deep generative models,…

Image and Video Processing · Electrical Eng. & Systems 2021-04-12 Jaime Simarro , Ezequiel de la Rosa , Thijs Vande Vyvere , David Robben , Diana M. Sima

Unsupervised anomaly detection (UAD) based on deep generative modelling has been increasingly explored for identifying pathological brain abnormalities without requiring voxel-level annotations. By learning the distribution of healthy…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Youwan Mahé , Elise Bannier , Stéphanie Leplaideur , Elisa Fromont , Francesca Galassi

Reliably modeling normality and differentiating abnormal appearances from normal cases is a very appealing approach for detecting pathologies in medical images. A plethora of such unsupervised anomaly detection approaches has been made in…

Computer Vision and Pattern Recognition · Computer Science 2019-04-19 Christoph Baur , Benedikt Wiestler , Shadi Albarqouni , Nassir Navab

The use of supervised deep learning techniques to detect pathologies in brain MRI scans can be challenging due to the diversity of brain anatomy and the need for annotated data sets. An alternative approach is to use unsupervised anomaly…

Image and Video Processing · Electrical Eng. & Systems 2023-03-08 Finn Behrendt , Debayan Bhattacharya , Julia Krüger , Roland Opfer , Alexander Schlaefer

The emergence of tau PET imaging over the last decade has enabled Alzheimer's disease (AD) researchers to examine tau pathology in vivo and more effectively characterize the disease trajectories of AD. Current tau PET analysis methods,…

Image and Video Processing · Electrical Eng. & Systems 2025-12-16 Lujia Zhong , Shuo Huang , Jiaxin Yue , Jianwei Zhang , Zhiwei Deng , Wenhao Chi , Yonggang Shi

Anomaly detection in medical imaging is a challenging task in contexts where abnormalities are not annotated. This problem can be addressed through unsupervised anomaly detection (UAD) methods, which identify features that do not match with…

Image and Video Processing · Electrical Eng. & Systems 2023-09-07 Geoffroy Oudoumanessah , Carole Lartizien , Michel Dojat , Florence Forbes

Harnessing the power of deep neural networks in the medical imaging domain is challenging due to the difficulties in acquiring large annotated datasets, especially for rare diseases, which involve high costs, time, and effort for…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Md Mahfuzur Rahman Siddiquee , Jay Shah , Teresa Wu , Catherine Chong , Todd J. Schwedt , Gina Dumkrieger , Simona Nikolova , Baoxin Li

The detection of lesions in magnetic resonance imaging (MRI)-scans of human brains remains challenging, time-consuming and error-prone. Recently, unsupervised anomaly detection (UAD) methods have shown promising results for this task. These…

Image and Video Processing · Electrical Eng. & Systems 2022-04-13 Finn Behrendt , Marcel Bengs , Frederik Rogge , Julia Krüger , Roland Opfer , Alexander Schlaefer

Unsupervised anomaly detection methods offer a promising and flexible alternative to supervised approaches, holding the potential to revolutionize medical scan analysis and enhance diagnostic performance. In the current landscape, it is…

Image and Video Processing · Electrical Eng. & Systems 2023-08-29 Cosmin I. Bercea , Esther Puyol-Antón , Benedikt Wiestler , Daniel Rueckert , Julia A. Schnabel , Andrew P. King

Deep unsupervised representation learning has recently led to new approaches in the field of Unsupervised Anomaly Detection (UAD) in brain MRI. The main principle behind these works is to learn a model of normal anatomy by learning to…

Image and Video Processing · Electrical Eng. & Systems 2020-04-09 Christoph Baur , Stefan Denner , Benedikt Wiestler , Shadi Albarqouni , Nassir Navab

The increasing digitization of medical imaging enables machine learning based improvements in detecting, visualizing and segmenting lesions, easing the workload for medical experts. However, supervised machine learning requires reliable…

Image and Video Processing · Electrical Eng. & Systems 2024-12-03 Maximilian E. Tschuchnig , Michael Gadermayr

It can be challenging to identify brain MRI anomalies using supervised deep-learning techniques due to anatomical heterogeneity and the requirement for pixel-level labeling. Unsupervised anomaly detection approaches provide an alternative…

Image and Video Processing · Electrical Eng. & Systems 2023-08-30 Hasan Iqbal , Umar Khalid , Jing Hua , Chen Chen

Deep unsupervised anomaly detection in brain magnetic resonance imaging offers a promising route to identify pathological deviations without requiring lesion-specific annotations. Yet, fragmented evaluations, heterogeneous datasets, and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Alexander Frotscher , Christian F. Baumgartner , Thomas Wolfers

Anomaly detection is the problem of recognizing abnormal inputs based on the seen examples of normal data. Despite recent advances of deep learning in recognizing image anomalies, these methods still prove incapable of handling complex…

Computer Vision and Pattern Recognition · Computer Science 2021-09-14 Nina Shvetsova , Bart Bakker , Irina Fedulova , Heinrich Schulz , Dmitry V. Dylov

Anomaly detection in medical imaging is to distinguish the relevant biomarkers of diseases from those of normal tissues. Deep supervised learning methods have shown potentials in various detection tasks, but its performances would be…

Image and Video Processing · Electrical Eng. & Systems 2021-12-01 Byungjai Kim , Kinam Kwon , Changheun Oh , Hyunwook Park

Unsupervised Anomaly Detection has become a popular method to detect pathologies in medical images as it does not require supervision or labels for training. Most commonly, the anomaly detection model generates a "normal" version of an…

Image and Video Processing · Electrical Eng. & Systems 2023-09-26 Felix Meissen , Johannes Paetzold , Georgios Kaissis , Daniel Rueckert

We propose a supervised anomaly detection method based on neural density estimators, where the negative log likelihood is used for the anomaly score. Density estimators have been widely used for unsupervised anomaly detection. By the recent…

Machine Learning · Statistics 2019-04-15 Tomoharu Iwata , Yuki Yamanaka

Detection of various lesions in brain MRI is clinically critical, but challenging due to the diversity of lesions and variability in imaging conditions. Current unsupervised learning methods detect anomalies mainly through reconstructing…

Computer Vision and Pattern Recognition · Computer Science 2025-12-29 Tao Yang , Xiuying Wang , Hao Liu , Guanzhong Gong , Lian-Ming Wu , Yu-Ping Wang , Lisheng Wang
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