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The growing volume of high-resolution Whole Slide Images in digital histopathology poses significant storage, transmission, and computational efficiency challenges. Standard compression methods, such as JPEG, reduce file sizes but often…

Image and Video Processing · Electrical Eng. & Systems 2025-03-17 Srikar Yellapragada , Alexandros Graikos , Kostas Triaridis , Zilinghan Li , Tarak Nath Nandi , Ravi K Madduri , Prateek Prasanna , Joel Saltz , Dimitris Samaras

Advancements in artificial intelligence have driven the development of numerous pathology foundation models capable of extracting clinically relevant information. However, there is currently limited literature independently evaluating these…

In digital pathology, many image analysis tasks are challenged by the need for large and time-consuming manual data annotations to cope with various sources of variability in the image domain. Unsupervised domain adaptation based on…

Image and Video Processing · Electrical Eng. & Systems 2022-05-18 Nassim Bouteldja , Barbara Mara Klinkhammer , Tarek Schlaich , Peter Boor , Dorit Merhof

With the rapid advancement of pathology foundation models (FMs), the representation learning of whole slide images (WSIs) attracts increasing attention. Existing studies develop high-quality patch feature extractors and employ carefully…

Computer Vision and Pattern Recognition · Computer Science 2025-03-27 Yuxuan Chen , Jiawen Li , Jiali Hu , Xitong Ling , Tian Guan , Anjia Han , Yonghong He

We developed a software pipeline for quality control (QC) of histopathology whole slide images (WSIs) that segments various regions, such as blurs of different levels, tissue regions, tissue folds, and pen marks. Given the necessity and…

Image and Video Processing · Electrical Eng. & Systems 2025-06-17 Abhijeet Patil , Garima Jain , Harsh Diwakar , Jay Sawant , Tripti Bameta , Swapnil Rane , Amit Sethi

Classification of histologic patterns in lung adenocarcinoma is critical for determining tumor grade and treatment for patients. However, this task is often challenging due to the heterogeneous nature of lung adenocarcinoma and the…

Computer Vision and Pattern Recognition · Computer Science 2019-02-01 Jason W. Wei , Laura J. Tafe , Yevgeniy A. Linnik , Louis J. Vaickus , Naofumi Tomita , Saeed Hassanpour

Whole slide image (WSI) classification is a critical task in computational pathology, requiring the processing of gigapixel-sized images, which is challenging for current deep-learning methods. Current state of the art methods are based on…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 Jingwei Zhang , Saarthak Kapse , Ke Ma , Prateek Prasanna , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

Histopathology whole slide images (WSIs) play a very important role in clinical studies and serve as the gold standard for many cancer diagnoses. However, generating automatic tools for processing WSIs is challenging due to their enormous…

Computer Vision and Pattern Recognition · Computer Science 2022-09-28 Jingwei Zhang , Xin Zhang , Ke Ma , Rajarsi Gupta , Joel Saltz , Maria Vakalopoulou , Dimitris Samaras

Recent rapid progress in the field of computational pathology has been enabled by foundation models. These models are beginning to move beyond encoding image patches towards whole-slide understanding but their clinical utility remains…

The recent development of deep learning large models in medicine shows remarkable performance in medical image analysis and diagnosis, but their large number of parameters causes memory and inference latency challenges. Knowledge…

Computer Vision and Pattern Recognition · Computer Science 2024-09-19 Shaojie Li , Zhaoshuo Diao

Deep-learning-based pipelines have shown the potential to revolutionalize microscopy image diagnostics by providing visual augmentations to a trained pathology expert. However, to match human performance, the methods rely on the…

Pathological is crucial to cancer diagnosis. Usually, Pathologists draw their conclusion based on observed cell and tissue structure on histology slides. Rapid development in machine learning, especially deep learning have established…

Image and Video Processing · Electrical Eng. & Systems 2020-01-15 Jiangbo Shi , Zeyu Gao , Haichuan Zhang , Pargorn Puttapirat , Chunbao Wang , Xiangrong Zhang , Chen Li

Segmentation of very large images is a common problem in microscopy, medical imaging or remote sensing. The problem is usually addressed by sliding window inference, which can theoretically lead to seamlessly stitched predictions. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Elena Buglakova , Anwai Archit , Edoardo D'Imprima , Julia Mahamid , Constantin Pape , Anna Kreshuk

Recently, representation learning with contrastive learning algorithms has been successfully applied to challenging unlabeled datasets. However, these methods are unable to distinguish important features from unimportant ones under simply…

Computer Vision and Pattern Recognition · Computer Science 2024-08-12 Toshiyuki Oshima , Kentaro Takagi , Kouta Nakata

The task of medical image segmentation presents unique challenges, necessitating both localized and holistic semantic understanding to accurately delineate areas of interest, such as critical tissues or aberrant features. This complexity is…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Pranav Singh , Luoyao Chen , Mei Chen , Jinqian Pan , Raviteja Chukkapalli , Shravan Chaudhari , Jacopo Cirrone

Self-supervised pre-training of deep learning models with contrastive learning is a widely used technique in image analysis. Current findings indicate a strong potential for contrastive pre-training on medical images. However, further…

Image and Video Processing · Electrical Eng. & Systems 2024-10-21 Daniel Wolf , Tristan Payer , Catharina Silvia Lisson , Christoph Gerhard Lisson , Meinrad Beer , Michael Götz , Timo Ropinski

Pathology is the study of microscopic inspection of tissue, and a pathology diagnosis is often the medical gold standard to diagnose disease. Pathology images provide a unique challenge for computer-vision-based analysis: a single pathology…

The detection of nuclei is one of the most fundamental components of computational pathology. Current state-of-the-art methods are based on deep learning, with the prerequisite that extensive labeled datasets are available. The increasing…

Image and Video Processing · Electrical Eng. & Systems 2019-07-11 Nicolas Brieu , Armin Meier , Ansh Kapil , Ralf Schoenmeyer , Christos G. Gavriel , Peter D. Caie , Günter Schmidt

High-quality labeled datasets are essential for deep learning. Traditional manual annotation methods are not only costly and inefficient but also pose challenges in specialized domains where expert knowledge is needed. Self-supervised…

Computer Vision and Pattern Recognition · Computer Science 2023-11-16 Zhaocong liu , Fa Zhang , Lin Cheng , Huanxi Deng , Xiaoyan Yang , Zhenyu Zhang , Chichun Zhou

Chronic kidney disease (CKD) is a major global health issue, affecting over 10% of the population and causing significant mortality. While kidney biopsy remains the gold standard for CKD diagnosis and treatment, the lack of comprehensive…