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Parkinson's disease is the world's fastest-growing neurological disorder. Research to elucidate the mechanisms of Parkinson's disease and automate diagnostics would greatly improve the treatment of patients with Parkinson's disease. Current…

Machine Learning · Computer Science 2024-02-20 Charlie Tran , Kai Shen , Kang Liu , Akshay Ashok , Adolfo Ramirez-Zamora , Jinghua Chen , Yulin Li , Ruogu Fang

Early and reliable detection of Alzheimer's disease (AD) is crucial for timely clinical intervention and improved patient management. It also supports the evaluation of emerging therapeutic strategies. In this paper, we propose a Low-Rank…

Machine Learning · Computer Science 2026-05-07 Wu Wang , Yuang Cheng , Fouzi Harrou , Ying Sun

Electroencephalography has been established as an effective method for detecting Parkinson's disease, typically diagnosed early.Current Parkinson's disease detection methods have shown significant success within individual datasets,…

Machine Learning · Computer Science 2025-08-21 Qian Zhang , Ruilin Zhang , Biaokai Zhu , Xun Han , Jun Xiao , Yifan Liu , Zhe Wang

Parkinson's disease (PD) belongs to the class of neurodegenerative disorders that affect the central nervous system. It is usually defined as the gradual loss of dopaminergic neurons in the substantia nigra pars compacta, which causes both…

Neurons and Cognition · Quantitative Biology 2024-11-01 Hina Shaheen , Roderick Melnik

Modern medicine requires generalised approaches to the synthesis and integration of multimodal data, often at different biological scales, that can be applied to a variety of evidence structures, such as complex disease analyses and…

Quantitative Methods · Quantitative Biology 2019-11-11 Devin Taylor , Simeon Spasov , Pietro Liò

Heart failure (HF) is one of the most prevalent life-threatening cardiovascular diseases in which 6.5 million people are suffering in the USA and more than 23 million worldwide. Mechanical circulatory support of HF patients can be achieved…

Machine Learning · Computer Science 2023-01-20 Masoud Fetanat , Michael Stevens , Pankaj Jain , Christopher Hayward , Erik Meijering , Nigel H. Lovell

Fundamental knowledge in activity recognition of individuals with motor disorders such as Parkinson's disease (PD) has been primarily limited to detection of steady-state/static tasks (sitting, standing, walking). To date, identification of…

Signal Processing · Electrical Eng. & Systems 2021-10-13 Mahdieh Kazemimoghadam , Nicholas P. Fey

In many clinical trials studying neurodegenerative diseases such as Parkinson's disease (PD), multiple longitudinal outcomes are collected to fully explore the multidimensional impairment caused by this disease. If the outcomes deteriorate…

Applications · Statistics 2017-05-18 Jue Wang , Sheng Luo , Liang Li

Physics-Informed Neural Networks (PINNs) have demonstrated considerable success in solving complex fluid dynamics problems. However, their performance often deteriorates in regimes characterized by steep gradients, intricate boundary…

Fluid Dynamics · Physics 2025-12-29 Ze Tao , Ke Xu , Fujun Liu

Heart disease is the leading cause of death, and experts estimate that approximately half of all heart attacks and strokes occur in people who have not been flagged as "at risk." Thus, there is an urgent need to improve the accuracy of…

Machine Learning · Computer Science 2018-08-23 Nathalie-Sofia Tomov , Stanimire Tomov

Parkinson's disease (PD) is a chronic neurodegenerative disease. Early diagnosis is essential to mitigate the progressive deterioration of patients' quality of life. The most characteristic motor symptoms are very mild in the early stages,…

Machine Learning · Computer Science 2026-01-27 Beatriz Pérez-Sánchez , Noelia Sánchez-Maroño , Miguel A. Díaz-Freire

Parkinson's disease is easy to diagnose when it is advanced, but it is very difficult to diagnose in its early stages. Early diagnosis is essential to be able to treat the symptoms. It impacts on daily activities and reduces the quality of…

This paper introduces a novel method to fine-tune handwriting recognition systems based on Recurrent Neural Networks (RNN). Long Short-Term Memory (LSTM) networks are good at modeling long sequences but they tend to overfit over time. To…

Computer Vision and Pattern Recognition · Computer Science 2021-02-02 Edgard Chammas , Chafic Mokbel

In this work, we use a deep learning framework for simultaneous classification and regression of Parkinson disease diagnosis based on MR-Images and personal information (i.e. age, gender). We intend to facilitate and increase the confidence…

Computer Vision and Pattern Recognition · Computer Science 2018-06-15 Soheil Esmaeilzadeh , Yao Yang , Ehsan Adeli

There is great interest in developing radiological classifiers for diagnosis, staging, and predictive modeling in progressive diseases such as Parkinson's disease (PD), a neurodegenerative disease that is difficult to detect in its early…

At present, the vast majority of human subjects with neurological disease are still diagnosed through in-person assessments and qualitative analysis of patient data. In this paper, we propose to use Topological Data Analysis (TDA) together…

Machine Learning · Computer Science 2020-05-07 Afra Nawar , Farhan Rahman , Narayanan Krishnamurthi , Anirudh Som , Pavan Turaga

Disease progression modeling (DPM) using longitudinal data is a challenging task in machine learning for healthcare that can provide clinicians with better tools for diagnosis and monitoring of disease. Existing DPM algorithms neglect…

Computer Vision and Pattern Recognition · Computer Science 2018-08-17 Mostafa Mehdipour Ghazi , Mads Nielsen , Akshay Pai , M. Jorge Cardoso , Marc Modat , Sebastien Ourselin , Lauge Sørensen

Parkinson's Disease (PD) is the second most common neurodegenerative disease in humans. PD is characterized by the gradual loss of dopaminergic neurons in the Substantia Nigra (SN). Counting the number of dopaminergic neurons in the SN is…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Fatemeh Haghighi , Soumitra Ghosh , Hai Ngu , Sarah Chu , Han Lin , Mohsen Hejrati , Baris Bingol , Somaye Hashemifar

Alzheimer's disease is one of the most incisive illnesses among the neurodegenerative ones, and it causes a progressive decline in cognitive abilities that, in the worst cases, becomes severe enough to interfere with daily life. Currently,…

Computer Vision and Pattern Recognition · Computer Science 2024-05-28 Tiziana D'Alessandro , Cristina Carmona-Duarte , Claudio De Stefano , Moises Diaz , Miguel A. Ferrer , Francesco Fontanella

Parkinsons Disease (PD) is a progressive neurological disorder that primarily affects motor functions and can lead to mild cognitive impairment (MCI) and dementia in its advanced stages. With approximately 10 million people diagnosed…

Image and Video Processing · Electrical Eng. & Systems 2025-05-02 Abu Saleh Musa Miah , taro Suzuki , Jungpil Shin
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