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Machine learning (ML) techniques have gained popularity in the neuroimaging field due to their potential for classifying neuropsychiatric disorders. However, the diagnostic predictive power of the existing algorithms has been limited by…

Major depressive disorder is a serious and heterogeneous psychiatric disorder that needs accurate diagnosis. Resting-state functional MRI (rsfMRI), which captures multiple perspectives on brain structure, function, and connectivity, is…

Machine Learning · Computer Science 2023-08-21 Yunsong Luo , Wenyu Chen , Ling Zhan , Jiang Qiu , Tao Jia

We currently observe a disconcerting phenomenon in machine learning studies in psychiatry: While we would expect larger samples to yield better results due to the availability of more data, larger machine learning studies consistently show…

Major depressive disorder (MDD) impacts more than 300 million people worldwide, highlighting a significant public health issue. However, the uneven distribution of medical resources and the complexity of diagnostic methods have resulted in…

Computation and Language · Computer Science 2025-05-02 Yuyang Sha , Hongxin Pan , Wei Xu , Weiyu Meng , Gang Luo , Xinyu Du , Xiaobing Zhai , Henry H. Y. Tong , Caijuan Shi , Kefeng Li

Background Major depressive disorder (MDD) is a leading cause of global disability, yet current diagnostic approaches often rely on subjective assessments and lack the ability to integrate multimodal clinical information. Large language…

Machine Learning · Computer Science 2025-09-30 Yuyang Sha , Hongxin Pan , Gang Luo , Caijuan Shi , Jing Wang , Kefeng Li

Major depressive disorder (MDD) is a prevalent mental disorder associated with complex neurobiological changes that cannot be fully captured using a single imaging modality. The use of multimodal magnetic resonance imaging (MRI) provides a…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Nojod M. Alotaibi , Areej M. Alhothali

Large-scale collaborative analysis of brain imaging data, in psychiatry and neu-rology, offers a new source of statistical power to discover features that boost ac-curacy in disease classification, differential diagnosis, and outcome…

Major depressive disorder (MDD) is a prevalent mental health condition that negatively impacts both individual well-being and global public health. Automated detection of MDD using structural magnetic resonance imaging (sMRI) and deep…

Computer Vision and Pattern Recognition · Computer Science 2025-11-05 Nojod M. Alotaibi , Areej M. Alhothali , Manar S. Ali

Depression has been the leading cause of mental-health illness worldwide. Major depressive disorder (MDD), is a common mental health disorder that affects both psychologically as well as physically which could lead to loss of lives. Due to…

Computer Vision and Pattern Recognition · Computer Science 2019-09-05 Anupama Ray , Siddharth Kumar , Rutvik Reddy , Prerana Mukherjee , Ritu Garg

Major depressive disorder (MDD) is one of the most common mental disorders, with significant impacts on many daily activities and quality of life. It stands as one of the most common mental disorders globally and ranks as the second leading…

Computer Vision and Pattern Recognition · Computer Science 2024-12-31 Nojod M. Alotaibi , Areej M. Alhothali , Manar S. Ali

Depression is ranked as the largest contributor to global disability and is also a major reason for suicide. Still, many individuals suffering from forms of depression are not treated for various reasons. Previous studies have shown that…

Computation and Language · Computer Science 2024-10-30 Marcel Trotzek , Sven Koitka , Christoph M. Friedrich

Depression has been a leading cause of mental-health illnesses across the world. While the loss of lives due to unmanaged depression is a subject of attention, so is the lack of diagnostic tests and subjectivity involved. Using behavioural…

Artificial Intelligence · Computer Science 2020-10-07 Shivani Shimpi , Shyam Thombre , Snehal Reddy , Ritik Sharma , Srijan Singh

Depression is a major mental health condition that severely impacts the emotional and physical well-being of individuals. The simple nature of data collection from social media platforms has attracted significant interest in properly…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Md Rezwanul Haque , Md. Milon Islam , S M Taslim Uddin Raju , Hamdi Altaheri , Lobna Nassar , Fakhri Karray

On the increase of major depressive disorders (MDD), many researchers paid attention to their recognition and treatment. Existing MDD recognition algorithms always use a single time-frequency domain method method, but the single…

Neurons and Cognition · Quantitative Biology 2021-11-03 Xiaofang Sun , Xiangwei Zheng , Yonghui Xu , Lizhen Cui , Bin Hu

Major Depressive Disorder (MDD) is a clinically heterogeneous syndrome with diverse etiological pathways. Traditional Epigenome-Wide Association Studies (EWAS) have successfully identified risk loci based on differential methylation…

Computational Engineering, Finance, and Science · Computer Science 2026-01-27 Mingyan Liu , Min Huang

Clinical depression or Major Depressive Disorder (MDD) is a common and serious medical illness. In this paper, a deep recurrent neural network-based framework is presented to detect depression and to predict its severity level from speech.…

Human-Computer Interaction · Computer Science 2020-03-13 Emna Rejaibi , Ali Komaty , Fabrice Meriaudeau , Said Agrebi , Alice Othmani

The increasing global prevalence of mental disorders, such as depression and PTSD, requires objective and scalable diagnostic tools. Traditional clinical assessments often face limitations in accessibility, objectivity, and consistency.…

Audio and Speech Processing · Electrical Eng. & Systems 2025-04-03 Abdelrahaman A. Hassan , Abdelrahman A. Ali , Aya E. Fouda , Radwa J. Hanafy , Mohammed E. Fouda

INTRODUCTION: The pharmacological treatment of Major Depressive Disorder (MDD) relies on a trial-and-error approach. We introduce an artificial intelligence (AI) model aiming to personalize treatment and improve outcomes, which was deployed…

Major Depressive Disorder (MDD) is a common worldwide mental health issue with high associated socioeconomic costs. The prediction and automatic detection of MDD can, therefore, make a huge impact on society. Speech, as a non-invasive, easy…

Depression has affected millions of people worldwide and has become one of the most common mental disorders. Early mental disorder detection can reduce costs for public health agencies and prevent other major comorbidities. Additionally,…

Computation and Language · Computer Science 2024-04-09 Giuliano Lorenzoni , Cristina Tavares , Nathalia Nascimento , Paulo Alencar , Donald Cowan
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