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Conditional diffusion models serve as the foundation of modern image synthesis and find extensive application in fields like computational biology and reinforcement learning. In these applications, conditional diffusion models incorporate…

Machine Learning · Computer Science 2024-03-19 Hengyu Fu , Zhuoran Yang , Mengdi Wang , Minshuo Chen

Diffusion models, a family of generative models based on deep learning, have become increasingly prominent in cutting-edge machine learning research. With a distinguished performance in generating samples that resemble the observed data,…

Machine Learning · Computer Science 2023-05-02 Lequan Lin , Zhengkun Li , Ruikun Li , Xuliang Li , Junbin Gao

Diffusion models have recently emerged as powerful generative models in medical imaging. However, it remains a major challenge to combine these data-driven models with domain knowledge to guide brain imaging problems. In neuroimaging,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Ana Lawry Aguila , Dina Zemlyanker , You Cheng , Sudeshna Das , Daniel C. Alexander , Oula Puonti , Annabel Sorby-Adams , W. Taylor Kimberly , Juan Eugenio Iglesias

Understanding causal dependencies in observational data is critical for informing decision-making. These relationships are often modeled as Bayesian Networks (BNs) and Directed Acyclic Graphs (DAGs). Existing methods, such as NOTEARS and…

Machine Learning · Computer Science 2026-04-03 Hao Zhu , Di Zhou , Donna Slonim

Discovering valid and meaningful mathematical equations from observed data plays a crucial role in scientific discovery. While this task, symbolic regression, remains challenging due to the vast search space and the trade-off between…

Machine Learning · Computer Science 2025-09-17 Xiaoxu Han , Chengzhen Ning , Jinghui Zhong , Fubiao Yang , Yu Wang , Xin Mu

In this note we present a generative model of natural images consisting of a deep hierarchy of layers of latent random variables, each of which follows a new type of distribution that we call rectified Gaussian. These rectified Gaussian…

Machine Learning · Statistics 2016-03-01 Tim Salimans

Graphical models are usually learned without regard to the cost of doing inference with them. As a result, even if a good model is learned, it may perform poorly at prediction, because it requires approximate inference. We propose an…

Artificial Intelligence · Computer Science 2012-06-18 Daniel Lowd , Pedro Domingos

While the mathematical foundations of score-based generative models are increasingly well understood for unconstrained Euclidean spaces, many practical applications involve data restricted to bounded domains. This paper provides a…

Statistics Theory · Mathematics 2026-03-26 Asbjørn Holk , Claudia Strauch , Lukas Trottner

In Gaussian graphical model selection, noise-corrupted samples present significant challenges. It is known that even minimal amounts of noise can obscure the underlying structure, leading to fundamental identifiability issues. A recent line…

Machine Learning · Statistics 2024-05-09 Abrar Zahin , Rajasekhar Anguluri , Lalitha Sankar , Oliver Kosut , Gautam Dasarathy

We introduce a framework for joint grounded scene graph - image generation, a challenging task involving high-dimensional, multi-modal structured data. To effectively model this complex joint distribution, we adopt a factorized approach:…

Computer Vision and Pattern Recognition · Computer Science 2025-08-05 Bicheng Xu , Qi Yan , Renjie Liao , Lele Wang , Leonid Sigal

Causal learning has long concerned itself with the accurate recovery of underlying causal mechanisms. Such causal modelling enables better explanations of out-of-distribution data. Prior works on causal learning assume that the high-level…

Sampling based on score diffusions has led to striking empirical results, and has attracted considerable attention from various research communities. It depends on availability of (approximate) Stein score functions for various levels of…

Statistics Theory · Mathematics 2026-01-01 M. J. Wainwright

The identification of structural differences between a music performance and the score is a challenging yet integral step of audio-to-score alignment, an important subtask of music information retrieval. We present a novel method to detect…

Sound · Computer Science 2021-02-16 Ruchit Agrawal , Daniel Wolff , Simon Dixon

A generative modeling framework is proposed that combines diffusion models and manifold learning to efficiently sample data densities on manifolds. The approach utilizes Diffusion Maps to uncover possible low-dimensional underlying (latent)…

Machine Learning · Computer Science 2025-04-22 Dimitris G. Giovanis , Ellis Crabtree , Roger G. Ghanem , Ioannis G. Kevrekidis

Diffusion generative models have emerged as a powerful framework for addressing problems in structural biology and structure-based drug design. These models operate directly on 3D molecular structures. Due to the unfavorable scaling of…

Biomolecules · Quantitative Biology 2024-05-10 Ian Dunn , David Ryan Koes

An active learning algorithm for the classification of high-dimensional images is proposed in which spatially-regularized nonlinear diffusion geometry is used to characterize cluster cores. The proposed method samples from estimated cluster…

Machine Learning · Computer Science 2019-11-07 James M. Murphy

In this paper, we propose a unified framework of denoising score-based models in the context of graduated non-convex energy minimization. We show that for sufficiently large noise variance, the associated negative log density -- the energy…

Machine Learning · Computer Science 2023-02-22 Erich Kobler , Thomas Pock

With the rapid evolution of synthetic media, Image Manipulation Localization (IML) has emerged as a critical component in multimedia forensics for ensuring the integrity of digital content. However, generalization remains a core challenge,…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Yunfei Wang , Bo Du , Zhe Yang , Xin Liu , Zhiyu Lin , Tianxin Xu , Ji-Zhe Zhou

Although statistical learning theory provides a robust framework to understand supervised learning, many theoretical aspects of deep learning remain unclear, in particular how different architectures may lead to inductive bias when trained…

Machine Learning · Computer Science 2024-03-27 Cédric Gerbelot , Avetik Karagulyan , Stefani Karp , Kavya Ravichandran , Menachem Stern , Nathan Srebro

We propose a class of structured diffusion models, in which the prior distribution is chosen as a mixture of Gaussians, rather than a standard Gaussian distribution. The specific mixed Gaussian distribution, as prior, can be chosen to…

Machine Learning · Computer Science 2024-10-28 Nanshan Jia , Tingyu Zhu , Haoyu Liu , Zeyu Zheng
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