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Large language models (LLMs) are deployed on increasingly complex tasks that require multi-step decision-making. Understanding their algorithmic reasoning abilities is therefore crucial. However, we lack a diagnostic benchmark for…

Machine Learning · Computer Science 2026-02-12 Yu He , Yingxi Li , Colin White , Ellen Vitercik

While large language models (LLMs), such as GPT-3, appear to be robust and general, their reasoning ability is not at a level to compete with the best models trained for specific natural language reasoning problems. In this study, we…

Computation and Language · Computer Science 2023-07-18 Zhun Yang , Adam Ishay , Joohyung Lee

One of the major barriers to using large language models (LLMs) in medicine is the perception they use uninterpretable methods to make clinical decisions that are inherently different from the cognitive processes of clinicians. In this…

Computation and Language · Computer Science 2023-08-15 Thomas Savage , Ashwin Nayak , Robert Gallo , Ekanath Rangan , Jonathan H Chen

With the advent of large language models (LLMs), the vast unstructured text within millions of academic papers is increasingly accessible for materials discovery, although significant challenges remain. While LLMs offer promising few- and…

Computation and Language · Computer Science 2025-09-30 Amit K Verma , Zhisong Zhang , Junwon Seo , Robin Kuo , Runbo Jiang , Emma Strubell , Anthony D Rollett

Large Language Models (LLMs) offer numerous applications, the full extent of which is not yet understood. This paper investigates if LLMs can be applied for editing structured and semi-structured documents with minimal effort. Using a…

Machine Learning · Computer Science 2024-09-16 Irene Weber

Large Language Models (LLMs) exhibit strong general reasoning but struggle in molecular science due to the lack of explicit chemical priors in standard string representations. Current solutions face a fundamental dilemma. Training-based…

Computation and Language · Computer Science 2025-12-23 Mingxu Zhang , Dazhong Shen , Qi Zhang , Ying Sun

Large language models (LLMs) have revolutionized many areas (e.g. natural language processing, software engineering, etc.) by achieving state-of-the-art performance on extensive downstream tasks. Aiming to achieve robust and general…

Artificial Intelligence · Computer Science 2024-01-18 Zhiming Li , Yushi Cao , Xiufeng Xu , Junzhe Jiang , Xu Liu , Yon Shin Teo , Shang-wei Lin , Yang Liu

Large Language Models (LLMs) have emerged as a transformative power in enhancing natural language comprehension, representing a significant stride toward artificial general intelligence. The application of LLMs extends beyond conventional…

This work presents an ontology-integrated large language model (LLM) framework for chemical engineering that unites structured domain knowledge with generative reasoning. The proposed pipeline aligns model training and inference with the…

Machine Learning · Computer Science 2025-12-15 Crystal Su , Kuai Yu , Jingrui Zhang , Mingyuan Shao , Daniel Bauer

Large language models (LLMs) have emerged as powerful tools in chemistry, significantly impacting molecule design, property prediction, and synthesis optimization. This review highlights LLM capabilities in these domains and their potential…

Machine Learning · Computer Science 2024-11-18 Mayk Caldas Ramos , Christopher J. Collison , Andrew D. White

While large language models (LLMs) with Chain-of-Thought (CoT) reasoning excel in mathematics and coding, their potential for systematic reasoning in chemistry, a domain demanding rigorous structural analysis for real-world tasks like drug…

Artificial Intelligence · Computer Science 2026-01-08 Hao Li , He Cao , Bin Feng , Yanjun Shao , Xiangru Tang , Zhiyuan Yan , Li Yuan , Yonghong Tian , Yu Li

Language interpretation is a compositional process, in which the meaning of more complex linguistic structures is inferred from the meaning of their parts. Large language models possess remarkable language interpretation capabilities and…

Artificial Intelligence · Computer Science 2025-10-31 David Maria Schmidt , Raoul Schubert , Philipp Cimiano

Large language models (LLMs) have recently shown remarkable performance in language tasks and beyond. However, due to their limited inherent causal reasoning ability, LLMs still face challenges in handling tasks that require robust causal…

Computation and Language · Computer Science 2025-03-13 Xin Li , Zhuo Cai , Shoujin Wang , Kun Yu , Fang Chen

Large language models (LLMs) have shown remarkable improvements in reasoning and many existing benchmarks have been addressed by models such as o1 and o3 either fully or partially. However, a majority of these benchmarks emphasize deductive…

Machine Learning · Computer Science 2025-05-15 Wenyue Hua , Tyler Wong , Sun Fei , Liangming Pan , Adam Jardine , William Yang Wang

Integrating free-text explanations to in-context learning of large language models (LLM) is shown to elicit strong reasoning capabilities along with reasonable explanations. In this paper, we consider the problem of leveraging the…

Computation and Language · Computer Science 2022-10-14 Shiyang Li , Jianshu Chen , Yelong Shen , Zhiyu Chen , Xinlu Zhang , Zekun Li , Hong Wang , Jing Qian , Baolin Peng , Yi Mao , Wenhu Chen , Xifeng Yan

Formal logic enables computers to reason in natural language by representing sentences in symbolic forms and applying rules to derive conclusions. However, in what our study characterizes as "rulebreaker" scenarios, this method can lead to…

Computation and Language · Computer Science 2025-08-18 Jason Chan , Robert Gaizauskas , Zhixue Zhao

Large language models (LLMs) such as ChatGPT and GPT-4 have shown impressive performance in complex reasoning tasks. However, it is difficult to know whether the models are reasoning based on deep understandings of truth and logic, or…

Computation and Language · Computer Science 2023-10-11 Boshi Wang , Xiang Yue , Huan Sun

This paper presents a study on the integration of domain-specific knowledge in prompt engineering to enhance the performance of large language models (LLMs) in scientific domains. A benchmark dataset is curated to encapsulate the intricate…

Computation and Language · Computer Science 2024-04-24 Hongxuan Liu , Haoyu Yin , Zhiyao Luo , Xiaonan Wang

Chemical synthesis, as a foundational methodology in the creation of transformative molecules, exerts substantial influence across diverse sectors from life sciences to materials and energy. Current chemical synthesis practices emphasize…

Recent developments in large language models (LLMs) have shown promise in enhancing the capabilities of natural language processing (NLP). Despite these successes, there remains a dearth of research dedicated to the NLP problem-solving…

Computation and Language · Computer Science 2023-10-20 Linxin Song , Jieyu Zhang , Lechao Cheng , Pengyuan Zhou , Tianyi Zhou , Irene Li
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