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Accurate medical image segmentation is crucial for diagnosis and analysis. However, the models without calibrated uncertainty estimates might lead to errors in downstream analysis and exhibit low levels of robustness. Estimating the…

Image and Video Processing · Electrical Eng. & Systems 2021-09-16 Yanwu Yang , Xutao Guo , Yiwei Pan , Pengcheng Shi , Haiyan Lv , Ting Ma

Despite the recent improvements in overall accuracy, deep learning systems still exhibit low levels of robustness. Detecting possible failures is critical for a successful clinical integration of these systems, where each data point…

Image and Video Processing · Electrical Eng. & Systems 2019-10-14 Alain Jungo , Mauricio Reyes

Quantifying uncertainties for machine learning (ML) models is a foundational challenge in modern data analysis. This challenge is compounded by at least two key aspects of the field: (a) inconsistent terminology surrounding uncertainty and…

Machine Learning · Computer Science 2025-06-04 Shubhendu Trivedi , Brian D. Nord

Uncertainty quantification (UQ) is an important component of molecular property prediction, particularly for drug discovery applications where model predictions direct experimental design and where unanticipated imprecision wastes valuable…

Machine Learning · Computer Science 2020-05-21 Lior Hirschfeld , Kyle Swanson , Kevin Yang , Regina Barzilay , Connor W. Coley

Neural networks (NNs) are currently changing the computational paradigm on how to combine data with mathematical laws in physics and engineering in a profound way, tackling challenging inverse and ill-posed problems not solvable with…

Machine Learning · Computer Science 2023-02-08 Apostolos F Psaros , Xuhui Meng , Zongren Zou , Ling Guo , George Em Karniadakis

Deep learning (DL) models have provided state-of-the-art performance in various medical imaging benchmarking challenges, including the Brain Tumor Segmentation (BraTS) challenges. However, the task of focal pathology multi-compartment…

Image and Video Processing · Electrical Eng. & Systems 2023-06-29 Raghav Mehta , Angelos Filos , Ujjwal Baid , Chiharu Sako , Richard McKinley , Michael Rebsamen , Katrin Datwyler , Raphael Meier , Piotr Radojewski , Gowtham Krishnan Murugesan , Sahil Nalawade , Chandan Ganesh , Ben Wagner , Fang F. Yu , Baowei Fei , Ananth J. Madhuranthakam , Joseph A. Maldjian , Laura Daza , Catalina Gomez , Pablo Arbelaez , Chengliang Dai , Shuo Wang , Hadrien Reynaud , Yuan-han Mo , Elsa Angelini , Yike Guo , Wenjia Bai , Subhashis Banerjee , Lin-min Pei , Murat AK , Sarahi Rosas-Gonzalez , Ilyess Zemmoura , Clovis Tauber , Minh H. Vu , Tufve Nyholm , Tommy Lofstedt , Laura Mora Ballestar , Veronica Vilaplana , Hugh McHugh , Gonzalo Maso Talou , Alan Wang , Jay Patel , Ken Chang , Katharina Hoebel , Mishka Gidwani , Nishanth Arun , Sharut Gupta , Mehak Aggarwal , Praveer Singh , Elizabeth R. Gerstner , Jayashree Kalpathy-Cramer , Nicolas Boutry , Alexis Huard , Lasitha Vidyaratne , Md Monibor Rahman , Khan M. Iftekharuddin , Joseph Chazalon , Elodie Puybareau , Guillaume Tochon , Jun Ma , Mariano Cabezas , Xavier Llado , Arnau Oliver , Liliana Valencia , Sergi Valverde , Mehdi Amian , Mohammadreza Soltaninejad , Andriy Myronenko , Ali Hatamizadeh , Xue Feng , Quan Dou , Nicholas Tustison , Craig Meyer , Nisarg A. Shah , Sanjay Talbar , Marc-Andre Weber , Abhishek Mahajan , Andras Jakab , Roland Wiest , Hassan M. Fathallah-Shaykh , Arash Nazeri , Mikhail Milchenko1 , Daniel Marcus , Aikaterini Kotrotsou , Rivka Colen , John Freymann , Justin Kirby , Christos Davatzikos , Bjoern Menze , Spyridon Bakas , Yarin Gal , Tal Arbel

Quantifying uncertainty of machine learning model predictions is essential for reliable decision-making, especially in safety-critical applications. Recently, uncertainty quantification (UQ) theory has advanced significantly, building on a…

Machine Learning · Computer Science 2025-10-01 Alexander Fishkov , Kajetan Schweighofer , Mykyta Ielanskyi , Nikita Kotelevskii , Mohsen Guizani , Maxim Panov

Machine learning (ML) offers promising new approaches to tackle complex problems and has been increasingly adopted in chemical and materials sciences. Broadly speaking, ML models employ generic mathematical functions and attempt to learn…

Materials Science · Physics 2024-08-21 Jin Dai , Santosh Adhikari , Mingjian Wen

Uncertainty quantification (UQ) is essential for assessing the reliability of Earth observation (EO) products. However, the extensive use of machine learning models in EO introduces an additional layer of complexity, as those models…

Machine Learning · Computer Science 2024-12-10 Yuanyuan Wang , Qian Song , Dawood Wasif , Muhammad Shahzad , Christoph Koller , Jonathan Bamber , Xiao Xiang Zhu

Large Language Models (LLMs) have demonstrated remarkable capabilities across various tasks due to large training datasets and powerful transformer architecture. However, the reliability of responses from LLMs remains a question.…

Computation and Language · Computer Science 2025-02-26 Tiejin Chen , Xiaoou Liu , Longchao Da , Jia Chen , Vagelis Papalexakis , Hua Wei

The rapid advancement of large language models (LLMs) has transformed the landscape of natural language processing, enabling breakthroughs across a wide range of areas including question answering, machine translation, and text…

Computation and Language · Computer Science 2025-10-15 Sungmin Kang , Yavuz Faruk Bakman , Duygu Nur Yaldiz , Baturalp Buyukates , Salman Avestimehr

Classification and segmentation are crucial in medical image analysis as they enable accurate diagnosis and disease monitoring. However, current methods often prioritize the mutual learning features and shared model parameters, while…

Computer Vision and Pattern Recognition · Computer Science 2023-08-03 Kai Ren , Ke Zou , Xianjie Liu , Yidi Chen , Xuedong Yuan , Xiaojing Shen , Meng Wang , Huazhu Fu

Assessing the quality of aleatoric uncertainty estimates from uncertainty quantification (UQ) deep learning methods is important in scientific contexts, where uncertainty is physically meaningful and important to characterize and interpret…

Machine Learning · Computer Science 2024-11-14 Rebecca Nevin , Aleksandra Ćiprijanović , Brian D. Nord

Large Language Models (LLMs) excel in text generation, reasoning, and decision-making, enabling their adoption in high-stakes domains such as healthcare, law, and transportation. However, their reliability is a major concern, as they often…

Computation and Language · Computer Science 2025-06-05 Xiaoou Liu , Tiejin Chen , Longchao Da , Chacha Chen , Zhen Lin , Hua Wei

Uncertainty Quantification (UQ) has gained traction in an attempt to improve the interpretability and robustness of machine learning predictions. Specifically (medical) biosignals such as electroencephalography (EEG), electrocardiography…

Signal Processing · Electrical Eng. & Systems 2025-06-06 Ivo Pascal de Jong , Andreea Ioana Sburlea , Matias Valdenegro-Toro

Machine learning methods are increasingly widely used in high-risk settings such as healthcare, transportation, and finance. In these settings, it is important that a model produces calibrated uncertainty to reflect its own confidence and…

Artificial Intelligence · Computer Science 2022-09-09 Sophia Sun

Deep learning models for semantic segmentation are prone to poor performance in real-world applications due to the highly challenging nature of the task. Model uncertainty quantification (UQ) is one way to address this issue of lack of…

Computer Vision and Pattern Recognition · Computer Science 2022-11-04 Rishabh Singh , Jose C. Principe

Reliable uncertainty quantification (UQ) in machine learning (ML) regression tasks is becoming the focus of many studies in materials and chemical science. It is now well understood that average calibration is insufficient, and most studies…

Machine Learning · Statistics 2024-01-25 Pascal Pernot

Uncertainty quantification (UQ) is vital for ensuring that vision-language models (VLMs) behave safely and reliably. A central challenge is to localize uncertainty to its source, determining whether it arises from the image, the text, or…

Computer Vision and Pattern Recognition · Computer Science 2026-02-11 Chenyu Wang , Tianle Chen , H. M. Sabbir Ahmad , Kayhan Batmanghelich , Wenchao Li

Deep learning (DL) has shown great potential in medical image enhancement problems, such as super-resolution or image synthesis. However, to date, little consideration has been given to uncertainty quantification over the output image. Here…