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In order to tackle the difficulty associated with the ill-posed nature of the image registration problem, regularization is often used to constrain the solution space. For most learning-based registration approaches, the regularization…

Computer Vision and Pattern Recognition · Computer Science 2022-03-03 Zhe Xu , Jie Luo , Donghuan Lu , Jiangpeng Yan , Sarah Frisken , Jayender Jagadeesan , William Wells , Xiu Li , Yefeng Zheng , Raymond Tong

In this work we propose a deep learning network for deformable image registration (DIRNet). The DIRNet consists of a convolutional neural network (ConvNet) regressor, a spatial transformer, and a resampler. The ConvNet analyzes a pair of…

Computer Vision and Pattern Recognition · Computer Science 2017-12-08 Bob D. de Vos , Floris F. Berendsen , Max A. Viergever , Marius Staring , Ivana Išgum

Deformable registration is a fundamental task in medical image processing, aiming to achieve precise alignment by establishing nonlinear correspondences between images. Traditional methods offer good adaptability and interpretability but…

Computer Vision and Pattern Recognition · Computer Science 2025-05-13 Jing Hu , Kaiwei Yu , Hongjiang Xian , Shu Hu , Xin Wang

Nonlinear image registration continues to be a fundamentally important tool in medical image analysis. Diagnostic tasks, image-guided surgery and radiotherapy as well as motion analysis all rely heavily on accurate intra-patient alignment.…

Computer Vision and Pattern Recognition · Computer Science 2019-07-26 Mattias P. Heinrich

Regularization is essential in deformable image registration (DIR) to ensure that the estimated Deformation Vector Field (DVF) remains smooth, physically plausible, and anatomically consistent. However, fine-tuning regularization parameters…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Sidaty El Hadramy , Oumeymah Cherkaoui , Philippe C. Cattin

Optical diffraction tomography measures the three-dimensional refractive index map of a specimen and visualizes biochemical phenomena at the nanoscale in a non-destructive manner. One major drawback of optical diffraction tomography is poor…

Image and Video Processing · Electrical Eng. & Systems 2020-09-30 DongHun Ryu , Dongmin Ryu , YoonSeok Baek , Hyungjoo Cho , Geon Kim , Young Seo Kim , Yongki Lee , Yoosik Kim , Jong Chul Ye , Hyun-Seok Min , YongKeun Park

Image registration is used in many medical image analysis applications, such as tracking the motion of tissue in cardiac images, where cardiac kinematics can be an indicator of tissue health. Registration is a challenging problem for deep…

Image and Video Processing · Electrical Eng. & Systems 2025-06-25 Benjamin Graham

Diffeomorphic image registration (DIR) is a fundamental task in 3D medical image analysis that seeks topology-preserving deformations between image pairs. To ensure diffeomorphism, a common approach is to model the deformation field as the…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Mohammadjavad Matinkia , Nilanjan Ray

In recent literature there are plenty of works that combine handcrafted and learnable regularizers to solve inverse imaging problems. While this hybrid approach has demonstrated promising results, the motivation for combining handcrafted…

Computer Vision and Pattern Recognition · Computer Science 2025-05-23 Alexandros Gkillas , Dimitris Ampeliotis , Kostas Berberidis

The loss function of an unsupervised multimodal image registration framework has two terms, i.e., a metric for similarity measure and regularization. In the deep learning era, researchers proposed many approaches to automatically learn the…

Computer Vision and Pattern Recognition · Computer Science 2020-11-13 Zhe Xu , Jiangpeng Yan , Jie Luo , William Wells , Xiu Li , Jayender Jagadeesan

Image registration is a fundamental step in medical image analysis. Ideally, the transformation that registers one image to another should be a diffeomorphism that is both invertible and smooth. Traditional methods like geodesic shooting…

Computer Vision and Pattern Recognition · Computer Science 2019-07-02 Dongyang Kuang

Ultrasound deformable registration estimates spatial transformations between pairs of deformed ultrasound images, which is crucial for capturing biomechanical properties and enhancing diagnostic accuracy in diseases such as thyroid nodules…

Computer Vision and Pattern Recognition · Computer Science 2025-08-13 Yimeng Geng , Mingyang Zhao , Fan Xu , Guanglin Cao , Gaofeng Meng , Hongbin Liu

Deformable image registration plays a critical role in various tasks of medical image analysis. A successful registration algorithm, either derived from conventional energy optimization or deep networks requires tremendous efforts from…

Computer Vision and Pattern Recognition · Computer Science 2023-08-15 Xin Fan , Zi Li , Ziyang Li , Xiaolin Wang , Risheng Liu , Zhongxuan Luo , Hao Huang

Elasticity image, visualizing the quantitative map of tissue stiffness, can be reconstructed by solving an inverse problem. Classical methods for magnetic resonance elastography (MRE) try to solve a regularized optimization problem…

Image and Video Processing · Electrical Eng. & Systems 2021-05-28 Narges Mohammadi , Marvin M. Doyley , Mujdat Cetin

Regular mammography screening is crucial for early breast cancer detection. By leveraging deep learning-based risk models, screening intervals can be personalized, especially for high-risk individuals. While recent methods increasingly…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Solveig Thrun , Stine Hansen , Zijun Sun , Nele Blum , Suaiba A. Salahuddin , Xin Wang , Kristoffer Wickstrøm , Elisabeth Wetzer , Robert Jenssen , Maik Stille , Michael Kampffmeyer

We present a diffeomorphic image registration algorithm to learn spatial transformations between pairs of images to be registered using fully convolutional networks (FCNs) under a self-supervised learning setting. The network is trained to…

Computer Vision and Pattern Recognition · Computer Science 2020-10-06 Hongming Li , Yong Fan

In this paper, we propose a deep learning approach for image registration by predicting deformation from image appearance. Since obtaining ground-truth deformation fields for training can be challenging, we design a fully convolutional…

Computer Vision and Pattern Recognition · Computer Science 2018-02-14 Jingfan Fan , Xiaohuan Cao , Pew-Thian Yap , Dinggang Shen

Spatial transformations that capture population-level morphological statistics are critical for medical image analysis. Commonly used smoothness regularizers for image registration fail to integrate population statistics, leading to…

Computer Vision and Pattern Recognition · Computer Science 2025-07-08 Mokshagna Sai Teja Karanam , Krithika Iyer , Sarang Joshi , Shireen Elhabian

In recent years, learning-based image registration methods have gradually moved away from direct supervision with target warps to instead use self-supervision, with excellent results in several registration benchmarks. These approaches…

Computer Vision and Pattern Recognition · Computer Science 2022-05-17 Sean I. Young , Yaël Balbastre , Adrian V. Dalca , William M. Wells , Juan Eugenio Iglesias , Bruce Fischl

Medical image registration is one of the key processing steps for biomedical image analysis such as cancer diagnosis. Recently, deep learning based supervised and unsupervised image registration methods have been extensively studied due to…

Computer Vision and Pattern Recognition · Computer Science 2019-07-03 Boah Kim , Jieun Kim , June-Goo Lee , Dong Hwan Kim , Seong Ho Park , Jong Chul Ye