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The aim of this work is to develop a deep learning method for solving high-dimensional stochastic control problems based on the Hamilton--Jacobi--Bellman (HJB) equation and physics-informed learning. Our approach is to parameterize the…

Optimization and Control · Mathematics 2025-06-23 Zhe Jiao , Wantao Jia , Weiqiu Zhu

Objective. Precise control of neural systems is essential to experimental investigations of how the brain controls behavior and holds the potential for therapeutic manipulations to correct aberrant network states. Model predictive control,…

Neurons and Cognition · Quantitative Biology 2024-08-06 Christof Fehrman , C. Daniel Meliza

Deep brain stimulation (DBS) is an advanced surgical treatment for the symptoms of Parkinson's disease (PD), involving electrical stimulation of neurons within the basal ganglia region of the brain. DBS is traditionally delivered in an…

Systems and Control · Electrical Eng. & Systems 2025-06-19 Cédric Join , Jakub Orłowski , Antoine Chaillet , Madeleine Lowery , Hugues Mounier , Michel Fliess

Neurostimulation technologies have seen a recent surge in interest from the neuroscience and controls communities alike due to their proven potential to treat conditions such as Parkinson's Disease, and depression. The provided stimulation…

Systems and Control · Electrical Eng. & Systems 2023-01-03 Gagan Acharya , Sebastian F. Ruf , Erfan Nozari

We present a nonlinear data-driven Model Predictive Control (MPC) algorithm for deep brain stimulation (DBS) for the treatment of Parkinson's disease (PD). Although DBS is typically implemented in open-loop, closed-loop DBS (CLDBS) uses the…

Optimization and Control · Mathematics 2025-09-09 Sebastian Steffen , Mark Cannon

Deep brain stimulation (DBS) is a neurosurgical procedure successfully used to treat conditions such as Parkinson's disease. Electrostimulation, carried out by implanting electrodes into an identified focus in the brain, makes it possible…

Signal Processing · Electrical Eng. & Systems 2023-08-23 Arkadiusz Nowacki , Ewelina Kołpa , Mateusz Szychiewicz , Konrad Ciecierski

Mental disorders may exhibit pathological brain rhythms and neurostimulation promises to alleviate of patients' symptoms by modifying these rhythms. Today, most neurostimulation schemes are open-loop, i.e. administer experimental…

Neurons and Cognition · Quantitative Biology 2023-03-21 Thomas Wahl , Michel Duprez , Axel Hutt

In this paper, we introduce a model-based deep-learning approach to solve finite-horizon continuous-time stochastic control problems with jumps. We iteratively train two neural networks: one to represent the optimal policy and the other to…

Machine Learning · Computer Science 2026-01-16 Patrick Cheridito , Jean-Loup Dupret , Donatien Hainaut

Deep brain stimulation (DBS) has shown great promise toward treating motor symptoms caused by Parkinson's disease (PD), by delivering electrical pulses to the Basal Ganglia (BG) region of the brain. However, DBS devices approved by the U.S.…

We study the problem of generating control laws for systems with unknown dynamics. Our approach is to represent the controller and the value function with neural networks, and to train them using loss functions adapted from the…

Robotics · Computer Science 2023-02-21 Selim Engin , Volkan Isler

We present a neural network approach for approximating the value function of high-dimensional stochastic control problems. Our training process simultaneously updates our value function estimate and identifies the part of the state space…

Optimization and Control · Mathematics 2024-05-08 Xingjian Li , Deepanshu Verma , Lars Ruthotto

We propose a neural network approach that yields approximate solutions for high-dimensional optimal control problems and demonstrate its effectiveness using examples from multi-agent path finding. Our approach yields controls in a feedback…

Optimization and Control · Mathematics 2022-06-29 Derek Onken , Levon Nurbekyan , Xingjian Li , Samy Wu Fung , Stanley Osher , Lars Ruthotto

In this paper we deal with a feedback control design for the action potential of a neuronal membrane in relation with the non-linear dynamics of the Hodgkin-Huxley mathematical model. More exactly, by using an external current as a control…

Optimization and Control · Mathematics 2020-04-22 Cecilia Cavaterra , Denis Enachescu , Gabriela Marinoschi

A large scale computational model of the basal ganglia (BG) network is proposed to describes movement disorder including deep brain stimulation (DBS). The model of this complex network considers four areas of the basal ganglia network: the…

Neurons and Cognition · Quantitative Biology 2021-03-15 Konstantinos Spiliotis , Jens Starke , Denise Franz , Angelika Richter , Rüdiger Köhling

We propose a neural network approach for solving high-dimensional optimal control problems. In particular, we focus on multi-agent control problems with obstacle and collision avoidance. These problems immediately become high-dimensional,…

Optimization and Control · Mathematics 2022-05-05 Derek Onken , Levon Nurbekyan , Xingjian Li , Samy Wu Fung , Stanley Osher , Lars Ruthotto

We consider a singularly perturbed system of stochastic differential equations proposed by Chaudhari et al. (Res. Math. Sci. 2018) to approximate the Entropic Gradient Descent in the optimization of deep neural networks, via homogenisation.…

Optimization and Control · Mathematics 2024-03-11 Martino Bardi , Hicham Kouhkouh

This paper proposes a novel approach to improve the performance of distributed nonlinear control systems while preserving stability by leveraging Deep Neural Networks (DNNs). We build upon the Neural System Level Synthesis (Neur-SLS)…

Optimization and Control · Mathematics 2024-08-01 Danilo Saccani , Leonardo Massai , Luca Furieri , Giancarlo Ferrari-Trecate

A spiking neuron ``computes'' by transforming a complex dynamical input into a train of action potentials, or spikes. The computation performed by the neuron can be formulated as dimensional reduction, or feature detection, followed by a…

Biological Physics · Physics 2007-05-23 Blaise Aguera y Arcas , Adrienne L. Fairhall , William Bialek

This work is concerned with solving neural network-based feedback controllers efficiently for optimal control problems. We first conduct a comparative study of two prevalent approaches: offline supervised learning and online direct policy…

Optimization and Control · Mathematics 2024-04-10 Yue Zhao , Jiequn Han

Deep brain stimulation (DBS) is an established intervention for Parkinson's disease (PD), but conventional open-loop systems lack adaptability, are energy-inefficient due to continuous stimulation, and provide limited personalization to…

Machine Learning · Computer Science 2025-07-10 Harsh Ravivarapu , Gaurav Bagwe , Xiaoyong Yuan , Chunxiu Yu , Lan Zhang
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