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Multimode fibers (MMFs) are attractive ultra-thin replacements for state-of-the-art endoscopes, but the phase randomization in propagation through MMFs poses a major hurdle for imaging and focusing of light. Recently, this challenge has…

Optics · Physics 2015-06-30 Shamir Rosen , Doron Gilboa , Ori Katz , Yaron Silberberg

Imaging through optical multimode fibers (MMFs) has the potential to enable hair-thin endoscopes that reduce the invasiveness of imaging deep inside tissues and organs. Current approaches predominantly require active wavefront shaping and…

Optics · Physics 2021-12-13 Szu-Yu Lee , Vicente J. Parot , Brett E. Bouma , Martin Villiger

FRET-based approaches are a unique tool for sensing the immediate surroundings and interactions of (bio)molecules. FRET imaging and FLIM (Fluorescence Lifetime Imaging Microscopy) enable the visualization of the spatial distribution of…

Nonlinear structured illumination microscopy (nSIM) is an effective approach for super-resolution wide-field fluorescence microscopy with a theoretically unlimited resolution. In nSIM, carefully designed, highly-contrasted illumination…

The remarkable realism of images generated by diffusion models poses critical detection challenges. Current methods utilize reconstruction error as a discriminative feature, exploiting the observation that real images exhibit higher…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Jie Li , Yingying Feng , Chi Xie , Jie Hu , Lei Tan , Jiayi Ji

Nanoscale fabrication and characterisation techniques critically underpin a vast range of fields, including materials science, nanoelectronics and nanobiotechnology. Focused ion beam (FIB) techniques are particularly appealing due to their…

Fluorescence imaging is indispensable to biology and neuroscience. The need for large-scale imaging in freely behaving animals has further driven the development in miniaturized microscopes (miniscopes). However, conventional microscopes /…

Optics · Physics 2020-10-29 Yujia Xue , Ian G. Davison , David A. Boas , Lei Tian

Simultaneous imaging of fluorescence-labeled and label-free phase objects in the same sample provides distinct and complementary information. Most multimodal fluorescence-phase imaging operates in transmission mode, capturing fluorescence…

Optics · Physics 2024-08-20 Renzhi He , Yucheng Li , Junjie Chen , Yi Xue

Fluorescent nuclear track detectors (FNTD) show great potential for applications in ion-beam therapy research, such as dosimetry, advanced beam characterization, in-vivo use or as radiobiological assay. A essential feature of FNTDs is their…

Instrumentation and Detectors · Physics 2014-07-04 Steffen Greilich , Julia-Maria Osinga , Martin Niklas , Florian Lauer , Felix Bestvater , Oliver Jäkel

A flexible multimode fiber is an exceptionally efficient tool for in vivo deep tissue imaging. Recent advances in compressive multimode fiber sensing allow for imaging with sub-diffraction spatial resolution and sub-Nyquist speed. At…

Optics · Physics 2024-07-17 Zhouping Lyu , Shih-Te Hung , Carlas S. Smith , Lyubov V. Amitonova

A full-field chromatic confocal microscopy using a multispectral sensor was developed for quasi-one-shot microscopic 3D surface measurement. An innovative optical configuration employs a digital micromirror device (DMD) and a multispectral…

Confocal microscopy in combination with real-space particle tracking has proven to be a powerful tool in scientific fields such as soft matter physics, materials science and cell biology. However, 3D tracking of anisotropic particles in…

Soft Condensed Matter · Physics 2015-05-20 T. H. Besseling , M. Hermes , A. Kuijk , B. de Nijs , T. -S. Deng , M. Dijkstra , A. Imhof , A. van Blaaderen

Fiber-based confocal endomicroscopy has shown great promise for minimally-invasive deep-tissue imaging. Despite its advantages, confocal fiber-bundle endoscopy inherently suffers from undersampling due to the spacing between fiber cores,…

Optics · Physics 2023-05-25 Gil Weinberg , Uri Weiss , Ori Katz

Optical endoscopy plays a crucial role in minimally invasive medical diagnostics and therapeutic procedures. Nonetheless, state-of-the-art endoscopic zoom objectives are bulky, requiring multi-element lens actuation, which can limit…

We demonstrate a compact and easy-to-build computational camera for single-shot 3D imaging. Our lensless system consists solely of a diffuser placed in front of a standard image sensor. Every point within the volumetric field-of-view…

Computer Vision and Pattern Recognition · Computer Science 2017-10-06 Nick Antipa , Grace Kuo , Reinhard Heckel , Ben Mildenhall , Emrah Bostan , Ren Ng , Laura Waller

Fluorescence microscopy is essential to study biological structures and dynamics. However, existing systems suffer from a tradeoff between field-of-view (FOV), resolution, and complexity, and thus cannot fulfill the emerging need of…

Optics · Physics 2022-09-09 Yujia Xue , Qianwan Yang , Guorong Hu , Kehan Guo , Lei Tian

In recent years, large-scale pre-trained diffusion models have demonstrated their outstanding capabilities in image and video generation tasks. However, existing models tend to produce visual objects commonly found in the training dataset,…

Computer Vision and Pattern Recognition · Computer Science 2024-07-30 Changgu Chen , Libing Yang , Xiaoyan Yang , Lianggangxu Chen , Gaoqi He , CHangbo Wang , Yang Li

We describe the development of automated emission line detection software for the Fiber Multi-Object Spectrograph (FMOS), which is a near-infrared spectrograph fed by $400$ fibers from the $0.2$ deg$^2$ prime focus field of view of the…

Instrumentation and Methods for Astrophysics · Physics 2015-06-17 Motonari Tonegawa , Tomonori Totani , Fumihide Iwamuro , Masayuki Akiyama , Gavin Dalton , Karl Glazebrook , Kouji Ohta , Hiroyuki Okada , Kiyoto Yabe

Fluorescence lifetime imaging microscopy (FLIM) systems are limited by their slow processing speed, low signal-to-noise ratio (SNR), and expensive and challenging hardware setups. In this work, we demonstrate applying a denoising…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Varun Mannam , Yide Zhang , Xiaotong Yuan , Takashi Hato , Pierre C. Dagher , Evan L. Nichols , Cody J. Smith , Kenneth W. Dunn , Scott Howard

Far-field optical imaging inevitably involves low-pass spatial filtering, limiting the resolution. Moreover, conventional imaging suppresses high spatial frequency components close to the cutoff, making them invisible under noise,…

Quantum Physics · Physics 2026-05-08 Li Gong , Aonan Zhang , Madhura Ghosh Dastidar , Alexander Duplinskii , A. I. Lvovsky
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