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This survey provides a comprehensive exploration of applications of Topological Data Analysis (TDA) within neural network analysis. Using TDA tools such as persistent homology and Mapper, we delve into the intricate structures and behaviors…

Machine Learning · Computer Science 2024-01-04 Rubén Ballester , Carles Casacuberta , Sergio Escalera

This paper introduces advanced techniques of Topological Data Analysis (TDA) for unsupervised anomaly detection and customer segmentation in banking data. Using the Mapper algorithm and persistent homology, we develop unsupervised…

Machine Learning · Computer Science 2025-08-21 Leonardo Aldo Alejandro Barberi , Linda Maria De Cave

We present a new method for exploring cancer gene expression data based on tools from algebraic topology. Our method selects a small relevant subset from tens of thousands of genes while simultaneously identifying nontrivial higher order…

Genomics · Quantitative Biology 2014-10-15 Svetlana Lockwood , Bala Krishnamoorthy

We present an investigation of the applicability of topological data analysis (TDA) to the study of high-resolution confocal microscopy images of fibrin network structures from patients with oesophageal cancer undergoing intended curative…

Other Quantitative Biology · Quantitative Biology 2026-05-22 Thomas Burnett , Theresa Reinhold , Bea Bleile , Sophie Raynor , Freya Jensen , Martin Hermann , Tua Gyldenholm , Yossi Bokor Bleile

Persistent homology is a widely-used tool in topological data analysis (TDA) for understanding the underlying shape of complex data. By constructing a filtration of simplicial complexes from data points, it captures topological features…

Algebraic Topology · Mathematics 2025-10-23 Aleksei Luchinsky , Umar Islambekov

Spatial transcriptomics (ST) measures gene expression at a set of spatial locations in a tissue. Communities of nearby cells that express similar genes form \textit{spatial domains}. Specialized ST clustering algorithms have been developed…

Quantitative Methods · Quantitative Biology 2025-11-12 Perry Beamer , Zixuan Cang

Genomics, especially multi-omics, has made precision medicine feasible. The completion and publicly accessible multi-omics resource with clinical outcome, such as The Cancer Genome Atlas (TCGA) is a great test bed for developing…

Genomics · Quantitative Biology 2020-08-31 Lana X Garmire

Topological data analysis (TDA) is a rising branch in modern applied mathematics. It extracts topological structures as features of a given space and uses these features to analyze digital data. Persistent homology, one of the central tools…

Algebraic Topology · Mathematics 2025-05-26 Chuan-Shen Hu

Persistent topological Laplacians constitute a new class of tools in topological data analysis (TDA). They are motivated by the necessity to address challenges encountered in persistent homology when handling complex data. These Laplacians…

Algebraic Topology · Mathematics 2024-12-12 Xiaoqi Wei , Guo-Wei Wei

In this work we use the persistent homology method, a technique in topological data analysis (TDA), to extract essential topological features from the data space and combine them with deep learning features for classification tasks. In TDA,…

Computer Vision and Pattern Recognition · Computer Science 2023-11-14 Mariana Dória Prata Lima , Gilson Antonio Giraldi , Gastão Florêncio Miranda Junior

Topological Data Analysis (TDA) is a novel, and relatively new approach to analysing high-dimensional data sets. It does this by focussing on global properties like the shape and connectivity of the data giving it a significant advantage…

Instrumentation and Methods for Astrophysics · Physics 2019-04-26 Jeff Murugan , Duncan Robertson

Recently, persistent homology has had tremendous success in biomolecular data analysis. It works by examining the topological relationship or connectivity of a group of atoms in a molecule at a variety of scales, then rendering a family of…

Biomolecules · Quantitative Biology 2019-03-27 David Bramer , Guo-Wei Wei

Software libraries for Topological Data Analysis (TDA) offer limited support for interactive visualization. Most libraries only allow to visualize topological descriptors (e.g., persistence diagrams), and lose the connection with the…

Graphics · Computer Science 2022-04-22 Xueyi Bao , Guoxi Liu , Federico Iuricich

With advanced imaging, sequencing, and profiling technologies, multiple omics data become increasingly available and hold promises for many healthcare applications such as cancer diagnosis and treatment. Multimodal learning for integrative…

Genomics · Quantitative Biology 2022-12-20 Sina Tabakhi , Mohammod Naimul Islam Suvon , Pegah Ahadian , Haiping Lu

Persistent homology (PH) is a method used in topological data analysis (TDA) to study qualitative features of data that persist across multiple scales. It is robust to perturbations of input data, independent of dimensions and coordinates,…

Algebraic Topology · Mathematics 2017-09-13 Nina Otter , Mason A. Porter , Ulrike Tillmann , Peter Grindrod , Heather A. Harrington

Topological data analysis (TDA) aims to extract noise-robust features from a data set by examining the number and persistence of holes in its topology. We show that a computational problem closely related to a core task in TDA --…

Quantum Physics · Physics 2024-10-29 Casper Gyurik , Alexander Schmidhuber , Robbie King , Vedran Dunjko , Ryu Hayakawa

Machine learning models for repeated measurements are limited. Using topological data analysis (TDA), we present a classifier for repeated measurements which samples from the data space and builds a network graph based on the data topology.…

Machine Learning · Computer Science 2019-04-08 Henri Riihimäki , Wojciech Chachólski , Jakob Theorell , Jan Hillert , Ryan Ramanujam

Topological Data Analysis (TDA) gives practioners the ability to analyse the global structure of cybersecurity data. We use TDA for anomaly detection in host-based logs collected with the open-source Logging Made Easy (LME) project. We…

Machine Learning · Computer Science 2022-04-28 Thomas Davies

Topological Data Analysis (TDA) is increasingly crucial in investigating the shape of complex data structures across scientific fields, particularly in neuroscience and finance. This study delves into persistent homology, a TDA component…

Physics and Society · Physics 2024-09-17 Roel Gisolf , Fernando A. N. Santos , Felix Wierstra

We use methods from topological data analysis to study the topological features of certain distributions of string vacua. Topological data analysis is a multi-scale approach used to analyze the topological features of a dataset by…

High Energy Physics - Theory · Physics 2016-04-20 Michele Cirafici