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Deep learning-based computer-aided diagnosis is gradually deployed to review and analyze medical images. However, this paradigm is restricted in real-world clinical applications due to the poor robustness and generalization. The issue is…

Computer Vision and Pattern Recognition · Computer Science 2022-03-22 Yurong Chen

Successful unsupervised domain adaptation is guaranteed only under strong assumptions such as covariate shift and overlap between input domains. The latter is often violated in high-dimensional applications like image classification which,…

Machine Learning · Computer Science 2024-06-13 Adam Breitholtz , Anton Matsson , Fredrik D. Johansson

Medical image segmentation plays a crucial role in clinical workflows, but domain shift often leads to performance degradation when models are applied to unseen clinical domains. This challenge arises due to variations in imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Yingkai Wang , Yaoyao Zhu , Xiuding Cai , Yuhao Xiao , Haotian Wu , Yu Yao

This work provides a strong baseline for the problem of multi-source multi-target domain adaptation and generalization in medical imaging. Using a diverse collection of ten chest X-ray datasets, we empirically demonstrate the benefits of…

Computer Vision and Pattern Recognition · Computer Science 2019-07-30 Li Yao , Jordan Prosky , Ben Covington , Kevin Lyman

Medical Image Analysis (MedIA) has emerged as a crucial tool in computer-aided diagnosis systems, particularly with the advancement of deep learning (DL) in recent years. However, well-trained deep models often experience significant…

Computer Vision and Pattern Recognition · Computer Science 2024-02-14 Ziwei Niu , Shuyi Ouyang , Shiao Xie , Yen-wei Chen , Lanfen Lin

Histopathological images are essential for medical diagnosis and treatment planning, but interpreting them accurately using machine learning can be challenging due to variations in tissue preparation, staining and imaging protocols. Domain…

Computer Vision and Pattern Recognition · Computer Science 2023-11-01 Vaibhav Khamankar , Sutanu Bera , Saumik Bhattacharya , Debashis Sen , Prabir Kumar Biswas

The ability of machine learning (ML) algorithms to generalize well to unseen data has been studied through the lens of information theory, by bounding the generalization error with the input-output mutual information (MI), i.e., the MI…

Machine Learning · Statistics 2024-06-07 Kimia Nadjahi , Kristjan Greenewald , Rickard Brüel Gabrielsson , Justin Solomon

This paper investigates discrepancies in how neural networks learn from different imaging domains, which are commonly overlooked when adopting computer vision techniques from the domain of natural images to other specialized domains such as…

Computer Vision and Pattern Recognition · Computer Science 2024-02-22 Nicholas Konz , Maciej A. Mazurowski

In real-life applications, machine learning models often face scenarios where there is a change in data distribution between training and test domains. When the aim is to make predictions on distributions different from those seen at…

Machine Learning · Computer Science 2021-11-04 Lucas Mansilla , Rodrigo Echeveste , Diego H. Milone , Enzo Ferrante

Vision foundation models are increasingly moving beyond 2D to volumetric domains such as 3D medical imaging, where unified pretraining across different imaging modalities (i.e. CT, MRI, and PET) could provide foundational models for diverse…

Computer Vision and Pattern Recognition · Computer Science 2026-05-11 Ho Hin Lee , Dongna Du , Chu Wang , Yuankai Huo , Shi Gu , James C. Gee , Yifan Wu

Domain generalization typically requires data from multiple source domains for model learning. However, such strong assumption may not always hold in practice, especially in medical field where the data sharing is highly concerned and…

Computer Vision and Pattern Recognition · Computer Science 2022-06-30 Quande Liu , Cheng Chen , Qi Dou , Pheng-Ann Heng

Learning using privileged information (LUPI) is a powerful heterogenous feature space machine learning framework that allows a machine learning model to learn from highly informative or privileged features which are available during…

Machine Learning · Computer Science 2019-03-26 Amina Asif , Muhammad Dawood , Fayyaz ul Amir Afsar Minhas

Machine Learning (ML) models are very effective in many learning tasks, due to the capability to extract meaningful information from large data sets. Nevertheless, there are learning problems that cannot be easily solved relying on pure…

Machine Learning · Computer Science 2021-01-29 Andrea Borghesi , Federico Baldo , Michele Lombardi , Michela Milano

Diabetic Retinopathy (DR), a leading cause of vision impairment, requires early detection and treatment. Developing robust AI models for DR classification holds substantial potential, but a key challenge is ensuring their generalization in…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Sanoojan Baliah , Fadillah A. Maani , Santosh Sanjeev , Muhammad Haris Khan

Recent advances in deep learning for medical image segmentation demonstrate expert-level accuracy. However, in clinically realistic environments, such methods have marginal performance due to differences in image domains, including…

Computer Vision and Pattern Recognition · Computer Science 2019-06-13 Ling Zhang , Xiaosong Wang , Dong Yang , Thomas Sanford , Stephanie Harmon , Baris Turkbey , Holger Roth , Andriy Myronenko , Daguang Xu , Ziyue Xu

In this paper, we address domain shifts in pathological images by focusing on shifts within whole slide images~(WSIs), such as patient characteristics and tissue thickness, rather than shifts between hospitals. Traditional approaches rely…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Yuki Shigeyasu , Shota Harada , Akihiko Yoshizawa , Kazuhiro Terada , Naoki Nakazima , Mariyo Kurata , Hiroyuki Abe , Tetsuo Ushiku , Ryoma Bise

Learning Using Privileged Information is a particular type of knowledge distillation where the teacher model benefits from an additional data representation during training, called privileged information, improving the student model, which…

Computation and Language · Computer Science 2024-08-20 Rafael-Edy Menadil , Mariana-Iuliana Georgescu , Radu Tudor Ionescu

The limited availability of large image datasets, mainly due to data privacy and differences in acquisition protocols or hardware, is a significant issue in the development of accurate and generalizable machine learning methods in medicine.…

Deep learning models for medical image analysis easily suffer from distribution shifts caused by dataset artifacts bias, camera variations, differences in the imaging station, etc., leading to unreliable diagnoses in real-world clinical…

Image and Video Processing · Electrical Eng. & Systems 2024-01-09 Siyuan Yan , Chi Liu , Zhen Yu , Lie Ju , Dwarikanath Mahapatra , Brigid Betz-Stablein , Victoria Mar , Monika Janda , Peter Soyer , Zongyuan Ge

The deep learning technique has been shown to be effectively addressed several image analysis tasks in the computer-aided diagnosis scheme for mammography. The training of an efficacious deep learning model requires large data with diverse…

Computer Vision and Pattern Recognition · Computer Science 2023-09-08 Zheren Li , Zhiming Cui , Lichi Zhang , Sheng Wang , Chenjin Lei , Xi Ouyang , Dongdong Chen , Xiangyu Zhao , Yajia Gu , Zaiyi Liu , Chunling Liu , Dinggang Shen , Jie-Zhi Cheng