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Uncertainty estimation is critical for numerous applications of deep neural networks and draws growing attention from researchers. Here, we demonstrate an uncertainty quantification approach for deep neural networks used in inverse problems…

Computer Vision and Pattern Recognition · Computer Science 2023-12-15 Luzhe Huang , Jianing Li , Xiaofu Ding , Yijie Zhang , Hanlong Chen , Aydogan Ozcan

Despite the huge success of deep neural networks (NNs), finding good mechanisms for quantifying their prediction uncertainty is still an open problem. Bayesian neural networks are one of the most popular approaches to uncertainty…

Machine Learning · Statistics 2020-01-01 Agustinus Kristiadi , Sina Däubener , Asja Fischer

Automatic classification of diabetic retinopathy from retinal images has been widely studied using deep neural networks with impressive results. However, there is a clinical need for estimation of the uncertainty in the classifications, a…

Computer Vision and Pattern Recognition · Computer Science 2022-02-03 Joel Jaskari , Jaakko Sahlsten , Theodoros Damoulas , Jeremias Knoblauch , Simo Särkkä , Leo Kärkkäinen , Kustaa Hietala , Kimmo Kaski

Uncertainty estimation is essential to make neural networks trustworthy in real-world applications. Extensive research efforts have been made to quantify and reduce predictive uncertainty. However, most existing works are designed for…

Machine Learning · Computer Science 2022-10-07 Myong Chol Jung , He Zhao , Joanna Dipnall , Belinda Gabbe , Lan Du

The optimization foundations of deep linear networks have recently received significant attention. However, due to their inherent non-convexity and hierarchical structure, analyzing the loss functions of deep linear networks remains a…

Optimization and Control · Mathematics 2025-09-24 Po Chen , Rujun Jiang , Peng Wang

Standard recognition approaches are unable to deal with novel categories at test time. Their overconfidence on the known classes makes the predictions unreliable for safety-critical applications such as healthcare or autonomous driving.…

Computer Vision and Pattern Recognition · Computer Science 2023-07-13 Lorenzo Li Lu , Giulia D'Ascenzi , Francesco Cappio Borlino , Tatiana Tommasi

In many real applications that use and analyze networked data, the links in the network graph may be erroneous, or derived from probabilistic techniques. In such cases, the node classification problem can be challenging, since the…

Databases · Computer Science 2014-05-23 Michele Dallachiesa , Charu Aggarwal , Themis Palpanas

With model trustworthiness being crucial for sensitive real-world applications, practitioners are putting more and more focus on improving the uncertainty calibration of deep neural networks. Calibration errors are designed to quantify the…

Machine Learning · Computer Science 2024-03-14 Sebastian G. Gruber , Florian Buettner

Convolutional neural networks (CNNs) are extremely popular and effective for image classification tasks but tend to be overly confident in their predictions. Various works have sought to quantify uncertainty associated with these models,…

Computer Vision and Pattern Recognition · Computer Science 2026-01-12 Sara Pohland , Claire Tomlin

One of the challenges for neural networks in real-life applications is the overconfident errors these models make when the data is not from the original training distribution. Addressing this issue is known as Out-of-Distribution (OOD)…

Computer Vision and Pattern Recognition · Computer Science 2024-07-24 Sina Sharifi , Taha Entesari , Bardia Safaei , Vishal M. Patel , Mahyar Fazlyab

Regularization of Deep Neural Networks (DNNs) for the sake of improving their generalization capability is important and challenging. The development in this line benefits theoretical foundation of DNNs and promotes their usability in…

Machine Learning · Computer Science 2019-11-19 Yingzhen Yang , Jiahui Yu , Xingjian Li , Jun Huan , Thomas S. Huang

Deep neural networks often predict samples with high confidence even when they come from unseen classes and should instead be flagged for expert evaluation. Current novelty detection algorithms cannot reliably identify such near OOD points…

Machine Learning · Computer Science 2022-03-14 Alexandru Ţifrea , Eric Stavarache , Fanny Yang

To detect distribution shifts and improve model safety, many out-of-distribution (OOD) detection methods rely on the predictive uncertainty or features of supervised models trained on in-distribution data. In this paper, we critically…

Machine Learning · Computer Science 2025-07-03 Yucen Lily Li , Daohan Lu , Polina Kirichenko , Shikai Qiu , Tim G. J. Rudner , C. Bayan Bruss , Andrew Gordon Wilson

Uncertainty quantification is a central challenge in reliable and trustworthy machine learning. Naive measures such as last-layer scores are well-known to yield overconfident estimates in the context of overparametrized neural networks.…

Machine Learning · Computer Science 2023-05-24 Lucas Clarté , Bruno Loureiro , Florent Krzakala , Lenka Zdeborová

Deep neural networks (DNNs) have made a revolution in numerous fields during the last decade. However, in tasks with high safety requirements, such as medical or autonomous driving applications, providing an assessment of the models…

Machine Learning · Computer Science 2020-11-20 Omer Achrack , Raizy Kellerman , Ouriel Barzilay

Uncertainty estimation has been widely studied in medical image segmentation as a tool to provide reliability, particularly in deep learning approaches. However, previous methods generally lack effective supervision in uncertainty…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Yuzhu Li , An Sui , Fuping Wu , Xiahai Zhuang

A widely recognized limitation of molecular prediction models is their reliance on structures observed in the training data, resulting in poor generalization to out-of-distribution compounds. Yet in drug discovery, the compounds most…

Machine Learning · Computer Science 2026-01-05 Jina Kim , Jeffrey Willette , Bruno Andreis , Sung Ju Hwang

In recent years, new regularization methods based on (deep) neural networks have shown very promising empirical performance for the numerical solution of ill-posed problems, e.g., in medical imaging and imaging science. Due to the…

Numerical Analysis · Mathematics 2024-06-07 Tim Jahn , Bangti Jin

Supervised classification methods often assume the train and test data distributions are the same and that all classes in the test set are present in the training set. However, deployed classifiers often require the ability to recognize…

Computer Vision and Pattern Recognition · Computer Science 2021-01-27 Ryne Roady , Tyler L. Hayes , Ronald Kemker , Ayesha Gonzales , Christopher Kanan

Deep neural networks with millions of parameters may suffer from poor generalization due to overfitting. To mitigate the issue, we propose a new regularization method that penalizes the predictive distribution between similar samples. In…

Machine Learning · Computer Science 2020-04-08 Sukmin Yun , Jongjin Park , Kimin Lee , Jinwoo Shin