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Related papers: Generalization in medical AI: a perspective on dev…

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Medicine is inherently multimodal, with rich data modalities spanning text, imaging, genomics, and more. Generalist biomedical artificial intelligence (AI) systems that flexibly encode, integrate, and interpret this data at scale can…

This paper explores the advancements and applications of large-scale models in the medical field, with a particular focus on Medical Large Models (MedLMs). These models, encompassing Large Language Models (LLMs), Vision Models, 3D Large…

Artificial Intelligence · Computer Science 2025-10-08 YunHe Su , Zhengyang Lu , Junhui Liu , Ke Pang , Haoran Dai , Sa Liu , Yuxin Jia , Lujia Ge , Jing-min Yang

The scarcity and complexity of voxel-level annotations in 3D medical imaging present significant challenges, particularly due to the domain gap between labeled datasets from well-resourced centers and unlabeled datasets from less-resourced…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Haifan Gong , Yitao Wang , Yihan Wang , Jiashun Xiao , Xiang Wan , Haofeng Li

Medical image segmentation is vital for modern healthcare and is a key element of computer-aided diagnosis. While recent advancements in computer vision have explored unsupervised segmentation using pre-trained models, these methods have…

Computer Vision and Pattern Recognition · Computer Science 2025-08-07 Mosong Ma , Tania Stathaki , Michalis Lazarou

Deep learning models perform best when tested on target (test) data domains whose distribution is similar to the set of source (train) domains. However, model generalization can be hindered when there is significant difference in the…

Computer Vision and Pattern Recognition · Computer Science 2020-08-19 Pulkit Khandelwal , Paul Yushkevich

Artificial intelligence (AI) generally and machine learning (ML) specifically demonstrate impressive practical success in many different application domains, e.g. in autonomous driving, speech recognition, or recommender systems. Deep…

Artificial Intelligence · Computer Science 2018-01-02 Andreas Holzinger , Chris Biemann , Constantinos S. Pattichis , Douglas B. Kell

Deep neural networks excel in medical imaging but remain prone to biases, leading to fairness gaps across demographic groups. We provide the first systematic exploration of Human-AI alignment and fairness in this domain. Our results show…

Computer Vision and Pattern Recognition · Computer Science 2025-05-16 Haozhe Luo , Ziyu Zhou , Zixin Shu , Aurélie Pahud de Mortanges , Robert Berke , Mauricio Reyes

Distributed learning provides an attractive framework for scaling the learning task by sharing the computational load over multiple nodes in a network. Here, we investigate the performance of distributed learning for large-scale linear…

Machine Learning · Statistics 2021-11-03 Martin Hellkvist , Ayça Özçelikkale , Anders Ahlén

Deep Learning failure cases are abundant, particularly in the medical area. Recent studies in out-of-distribution generalization have advanced considerably on well-controlled synthetic datasets, but they do not represent medical imaging…

Computer Vision and Pattern Recognition · Computer Science 2022-08-23 Alceu Bissoto , Catarina Barata , Eduardo Valle , Sandra Avila

Deep neural networks (DNNs) have revolutionized artificial intelligence but often lack performance when faced with out-of-distribution (OOD) data, a common scenario due to the inevitable domain shifts in real-world applications. This…

Machine Learning · Computer Science 2024-08-23 Arsham Gholamzadeh Khoee , Yinan Yu , Robert Feldt

Generalization is one of the key challenges in the clinical validation and application of deep learning models to medical images. Studies have shown that such models trained on publicly available datasets often do not work well on…

Computer Vision and Pattern Recognition · Computer Science 2020-03-04 Yu Zhang , Gongbo Liang , Nathan Jacobs , Xiaoqin Wang

This paper examines what it means for a medical AI system to be right by grounding the question in a specific clinical context: the automatic classification of plasma cells in digitized bone marrow smears for the diagnosis of multiple…

Computer Vision and Pattern Recognition · Computer Science 2026-05-13 Antony Gitau

Though remarkable progress has been achieved in various vision tasks, deep neural networks still suffer obvious performance degradation when tested in out-of-distribution scenarios. We argue that the feature statistics (mean and standard…

Computer Vision and Pattern Recognition · Computer Science 2022-04-25 Xiaotong Li , Yongxing Dai , Yixiao Ge , Jun Liu , Ying Shan , Ling-Yu Duan

In open-world scenarios, where both novel classes and domains may exist, an ideal segmentation model should detect anomaly classes for safety and generalize to new domains. However, existing methods often struggle to distinguish between…

Computer Vision and Pattern Recognition · Computer Science 2024-11-07 Zhitong Gao , Bingnan Li , Mathieu Salzmann , Xuming He

Although multi-label learning can deal with many problems with label ambiguity, it does not fit some real applications well where the overall distribution of the importance of the labels matters. This paper proposes a novel learning…

Machine Learning · Computer Science 2016-04-06 Xin Geng

Explainable AI (XAI) is paramount in industry-grade AI; however existing methods fail to address this necessity, in part due to a lack of standardisation of explainability methods. The purpose of this paper is to offer a perspective on the…

Machine Learning · Computer Science 2020-10-26 Othman Benchekroun , Adel Rahimi , Qini Zhang , Tetiana Kodliuk

Medical Large Language Models (LLMs) are increasingly deployed for clinical decision support across diverse specialties, yet systematic evaluation of their robustness to adversarial misuse and privacy leakage remains inaccessible to most…

Cryptography and Security · Computer Science 2025-12-10 Jinghao Wang , Ping Zhang , Carter Yagemann

As artificial intelligence becomes increasingly pervasive and powerful, the ability to audit AI-based systems is growing in importance. However, explainability for artificial intelligence systems is not a one-size-fits-all solution;…

Human-Computer Interaction · Computer Science 2025-10-13 Nicola Rossberg , Bennett Kleinberg , Barry O'Sullivan , Luca Longo , Andrea Visentin

Avoiding out-of-distribution (OOD) data is critical for training supervised machine learning models in the medical imaging domain. Furthermore, obtaining labeled medical data is difficult and expensive since it requires expert annotators…

Computer Vision and Pattern Recognition · Computer Science 2022-10-05 Suraj Kothawade , Akshit Srivastava , Venkat Iyer , Ganesh Ramakrishnan , Rishabh Iyer

Recent technological advances in healthcare have led to unprecedented growth in patient data quantity and diversity. While artificial intelligence (AI) models have shown promising results in analyzing individual data modalities, there is…

Artificial Intelligence · Computer Science 2024-11-07 Daan Schouten , Giulia Nicoletti , Bas Dille , Catherine Chia , Pierpaolo Vendittelli , Megan Schuurmans , Geert Litjens , Nadieh Khalili
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