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Developing dedicated mixed-signal neuromorphic computing systems optimized for real-time sensory-processing in extreme edge-computing applications requires time-consuming design, fabrication, and deployment of full-custom neuromorphic…

Neural and Evolutionary Computing · Computer Science 2025-08-18 Fernando M. Quintana , Maryada , Pedro L. Galindo , Elisa Donati , Giacomo Indiveri , Fernando Perez-Peña

Biological neural networks are often modeled as systems of coupled, nonlinear, ordinary or partial differential equations. The number of differential equations used to model a network increases with the size of the network and the level of…

Neurons and Cognition · Quantitative Biology 2022-08-09 Rishika Mohanta , Collins Assisi

The face of simulation-based training has greatly evolved, with the most recent tools giving the ability to create virtual environments that rival realism. At first glance, it might appear that what the training sector needs is the most…

Graphics · Computer Science 2019-04-29 Philippe Lépinard , Sébastien Lozé

A key element of the European Union's Human Brain Project (HBP) and other large-scale brain research projects is simulation of large-scale model networks of neurons. Here we argue why such simulations will likely be indispensable for…

This paper introduces the MIP Platform architecture model, a novel AI-based cognitive computing platform architecture. The goal of the proposed application of MIP is to reduce the implementation burden for the usage of AI algorithms applied…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-03-31 Pasquale Giampa , Massimiliano Dibitonto

Computational psychiatry faces a fundamental trade-off: traditional reinforcement learning (RL) models offer interpretability but lack behavioral realism, while large language model (LLM) agents generate realistic behaviors but lack…

Artificial Intelligence · Computer Science 2026-03-06 Zuo Fei , Kezhi Wang , Xiaomin Chen , Yizhou Huang

Visual decoding of neurophysiological signals is a critical challenge for brain-computer interfaces (BCIs) and computational neuroscience. However, current approaches are often constrained by the systematic and stochastic gaps between…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Feixue Shao , Guangze Shi , Xueyu Liu , Yongfei Wu , Mingqiang Wei , Jianan Zhang , Jianbo Lu , Guiying Yan , Weihua Yang

Brain simulation, as one of the latest advances in artificial intelligence, facilitates better understanding about how information is represented and processed in the brain. The extreme complexity of human brain makes brain simulations only…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-05-17 Xin Du

MindSculpt enables users to generate a wide range of hybrid geometries in Grasshopper in real time simply by thinking about those geometries. This design tool combines a brain-computer interface (BCI) with the parametric design platform…

Human-Computer Interaction · Computer Science 2023-11-27 Qi Yang , Jesus G. Cruz-Garza , Saleh Kalantari

Scientific computing is increasingly incorporating the advancements in machine learning and the ability to work with large amounts of data. At the same time, machine learning models are becoming increasingly sophisticated and exhibit many…

Programming Languages · Computer Science 2019-07-19 Mike Innes , Alan Edelman , Keno Fischer , Chris Rackauckas , Elliot Saba , Viral B Shah , Will Tebbutt

In this work, we present a computing platform named digital twin brain (DTB) that can simulate spiking neuronal networks of the whole human brain scale and more importantly, a personalized biological brain structure. In comparison to most…

Foundation models are transforming neuroscience but are often prohibitively large, data-hungry, and difficult to deploy. Here, we introduce BrainSymphony, a lightweight and parameter-efficient foundation model with plug-and-play integration…

Quantitative Methods · Quantitative Biology 2026-02-13 Moein Khajehnejad , Forough Habibollahi , Devon Stoliker , Adeel Razi

Over the past few decades, neuroscience experiments have become increasingly complex and naturalistic. Experimental design has in turn become more challenging, as experiments must conform to an ever-increasing diversity of design…

Neurons and Cognition · Quantitative Biology 2020-12-07 Storm Slivkoff , Jack L. Gallant

Differentiable simulators are an emerging concept with applications in several fields, from reinforcement learning to optimal control. Their distinguishing feature is the ability to calculate analytic gradients with respect to the input…

Machine Learning · Computer Science 2021-11-10 Antonio Stanziola , Simon R. Arridge , Ben T. Cox , Bradley E. Treeby

The growing interest in brain-inspired computational models arises from the remarkable problem-solving efficiency of the human brain. Action recognition, a complex task in computational neuroscience, has received significant attention due…

Neural and Evolutionary Computing · Computer Science 2024-06-18 Alireza Nadafian , Milad Mozafari , Timothée Masquelier , Mohammad Ganjtabesh

The deep neural nets of modern artificial intelligence (AI) have not achieved defining features of biological intelligence, including abstraction, causal learning, and energy-efficiency. While scaling to larger models has delivered…

Neurons and Cognition · Quantitative Biology 2021-05-24 Joseph D. Monaco , Kanaka Rajan , Grace M. Hwang

Differentiable simulators provide an avenue for closing the sim-to-real gap by enabling the use of efficient, gradient-based optimization algorithms to find the simulation parameters that best fit the observed sensor readings. Nonetheless,…

Robotics · Computer Science 2021-05-21 Eric Heiden , David Millard , Erwin Coumans , Yizhou Sheng , Gaurav S. Sukhatme

In branching simulation, a novel approach to simulation presented in this paper, a multiplicity of plausible scenarios are concurrently developed and implemented. In conventional simulations of complex systems, there arise from time to time…

Computational Engineering, Finance, and Science · Computer Science 2007-05-23 Mark Burgin , Walter Karplus , Damon Liu

Simulating physical systems is a core component of scientific computing, encompassing a wide range of physical domains and applications. Recently, there has been a surge in data-driven methods to complement traditional numerical simulations…

Machine Learning · Computer Science 2021-08-19 Karl Otness , Arvi Gjoka , Joan Bruna , Daniele Panozzo , Benjamin Peherstorfer , Teseo Schneider , Denis Zorin

Surgical simulators have been widely used in training and evaluation of physicians and surgeons. Virtual reality augmented with haptic technology has made it feasible to develop more realistic surgical simulators. In this context, we set…

Medical Physics · Physics 2022-05-19 Reza Karimzadeh , Javad Sheikh , Hamed Azarnoush , Hossein Arabi