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We consider a randomised implementation of the finite element method (FEM) for elliptic partial differential equations on high-dimensional models. This is motivated by applications where model predictions are essential for real-time process…

Numerical Analysis · Mathematics 2019-07-30 Yue Wu , Dimitris Kamilis , Nick Polydorides

In this paper we present and analyze a constraint energy minimizing generalized multiscale finite element method for convection diffusion equation. To define the multiscale basis functions, we first build an auxiliary multiscale space by…

Numerical Analysis · Mathematics 2022-03-31 Lina Zhao , Eric Chung

The accurate sampling of protein dynamics is an ongoing challenge despite the utilization of High-Performance Computers (HPC) systems. Utilizing only "brute force" MD simulations requires an unacceptably long time to solution. Adaptive…

Quantitative Methods · Quantitative Biology 2020-09-25 Eugen Hruska , Vivekanandan Balasubramanian , Hyungro Lee , Shantenu Jha , Cecilia Clementi

Simulation-based problems involving mixed-variable inputs frequently feature domains that are hierarchical, conditional, heterogeneous, or tree-structured. These characteristics pose challenges for data representation, modeling, and…

Machine Learning · Computer Science 2026-01-21 Paul Saves , Edward Hallé-Hannan , Jasper Bussemaker , Youssef Diouane , Nathalie Bartoli

Multiscale topology optimization (TO) of hyperelastic materials remains computationally prohibitive due to the repeated solution of microscale boundary value problems. In this work, we present a concurrent multiscale topology optimization…

Computational Engineering, Finance, and Science · Computer Science 2026-04-09 Asghar A. Jadoon , Aryan Tyagi , L. River Spencer , Reese E. Jones , Manuel K. Rausch , Ryan Alberdi , D. Thomas Seidl , Jan N. Fuhg

We are focusing on bound constrained global optimization problems, whose objective functions are computationally expensive black-box functions and have multiple local minima. The recently popular Metric Stochastic Response Surface (MSRS)…

Machine Learning · Statistics 2014-10-24 Yilun Wang , Christine A. Shoemaker

Recent years have seen the emergence of nonlinear methods for solving partial differential equations (PDEs), such as physics-informed neural networks (PINNs). While these approaches often perform well in practice, their theoretical analysis…

Numerical Analysis · Mathematics 2025-08-27 Alexandre Magueresse , Santiago Badia

In this paper, we propose an adaptive keyframe selection method for improved 3D scene reconstruction in dynamic environments. The proposed method integrates two complementary modules: an error-based selection module utilizing photometric…

Robotics · Computer Science 2025-12-30 Raman Jha , Yang Zhou , Giuseppe Loianno

In a task where many similar inverse problems must be solved, evaluating costly simulations is impractical. Therefore, replacing the model $y$ with a surrogate model $y_s$ that can be evaluated quickly leads to a significant speedup. The…

Numerical Analysis · Mathematics 2024-05-15 Phillip Semler , Martin Weiser

Macromolecular and biomolecular folding landscapes typically contain high free energy barriers that impede efficient sampling of configurational space by standard molecular dynamics simulation. Biased sampling can artificially drive the…

Biological Physics · Physics 2018-11-01 Wei Chen , Andrew L Ferguson

A surrogate model that accurately predicts distribution system voltages is crucial for reliable smart grid planning and operation. This letter proposes a fixed-point data-driven surrogate modeling method that employs a limited dataset to…

Systems and Control · Electrical Eng. & Systems 2024-01-01 Hoang Tien Nguyen , Young-Jin Kim , Dae-Hyun Choi

This paper is concerned with the sample efficiency of reinforcement learning, assuming access to a generative model (or simulator). We first consider $\gamma$-discounted infinite-horizon Markov decision processes (MDPs) with state space…

Machine Learning · Computer Science 2025-03-18 Gen Li , Yuting Wei , Yuejie Chi , Yuxin Chen

We report a multiscale approach of broad applicability to stochastic reconstruction of multiphase materials, including porous ones. The approach devised uses an optimization method, such as the simulated annealing (SA) and the so-called…

Materials Science · Physics 2018-11-13 R. Piasecki , W. Olchawa , D. Frączek , R. Wiśniowski

Distributed consensus has been widely studied for sensor network applications. Whereas the asymptotic convergence rate has been extensively explored in prior work, other important and practical issues, including energy efficiency and link…

Networking and Internet Architecture · Computer Science 2013-04-10 Lei Chen , Jeff Frolik

We introduce a massively parallel replica-exchange grand-canonical sampling algorithm to simulate materials at realistic conditions, in particular surfaces and clusters in reactive atmospheres. Its purpose is to determine in an automated…

Materials Science · Physics 2019-11-20 Yuanyuan Zhou , Matthias Scheffler , Luca M. Ghiringhelli

Biological systems are governed by coupled interactions between intracellular metabolism and bioreactor operation that span multiple time scales. Constraint-based metabolic models are widely used to describe intracellular metabolism, but…

Quantitative Methods · Quantitative Biology 2026-03-30 Peter E. Carstensen , Teddy Groves , Lars K. Nielsen , Ulrich Krühne , Krist V. Gernaey , John B. Jørgensen

Sampling from constrained distributions has a wide range of applications, including in Bayesian optimization and robotics. Prior work establishes convergence and feasibility guarantees for constrained sampling, but assumes that the feasible…

Machine Learning · Computer Science 2026-05-13 Cornelius V. Braun , Tilman Burghoff , Marc Toussaint

To address the challenges of reliability analysis in high-dimensional probability spaces, this paper proposes a new metamodeling method that couples active subspace, heteroscedastic Gaussian process, and active learning. The active subspace…

Applications · Statistics 2024-04-11 Jungho Kim , Ziqi Wang , Junho Song

Target-oriented discovery under limited evaluation budgets requires making reliable progress in high-dimensional, heterogeneous design spaces where each new measurement is costly, whether experimental or high-fidelity simulation. We present…

Machine Learning · Computer Science 2026-02-04 Yixuan Zhang , Zhiyuan Li , Weijia He , Mian Dai , Chen Shen , Teng Long , Hongbin Zhang

The protein dynamics are common and important for their biological functions and properties, the study of which usually involves time-consuming molecular dynamics (MD) simulations in silico. Recently, generative models has been leveraged as…

Biomolecules · Quantitative Biology 2024-03-13 Jiarui Lu , Zuobai Zhang , Bozitao Zhong , Chence Shi , Jian Tang