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Understanding the role of astrocytes in brain computation is a nascent challenge, promising immense rewards, in terms of new neurobiological knowledge that can be translated into artificial intelligence. In our ongoing effort to identify…

Neurons and Cognition · Quantitative Biology 2018-07-10 Ioannis Polykretis , Vladimir Ivanov , Konstantinos P. Michmizos

The neuronal paradigm of studying the brain has left us with limitations in both our understanding of how neurons process information to achieve biological intelligence and how such knowledge may be translated into artificial intelligence…

Neurons and Cognition · Quantitative Biology 2020-05-12 Leo Kozachkov , Konstantinos P. Michmizos

Traditional artificial neural networks take inspiration from biological networks, using layers of neuron-like nodes to pass information for processing. More realistic models include spiking in the neural network, capturing the electrical…

Machine Learning · Computer Science 2025-03-11 Christopher S. Yang , Sylvester J. Gates , Dulara De Zoysa , Jaehoon Choe , Wolfgang Losert , Corey B. Hart

The participation of astrocytes in brain computation was formally hypothesized in 1992, coinciding with the discovery that these glial cells display a complex form of Ca2+ excitability. This fostered conceptual advances centered on the…

Neurons and Cognition · Quantitative Biology 2023-10-23 Ciaran Murphy-Royal , ShiNung Ching , Thomas Papouin

Within the complex neuroarchitecture of the brain, astrocytes play crucial roles in development, structure, and metabolism. These cells regulate neural activity through tripartite synapses, directly impacting cognitive processes such as…

Neural and Evolutionary Computing · Computer Science 2023-12-27 Guobin Shen , Dongcheng Zhao , Yiting Dong , Yang Li , Jindong Li , Kang Sun , Yi Zeng

The brain consists not only of neurons but also of non-neuronal cells, including astrocytes. Recent discoveries in neuroscience suggest that astrocytes directly regulate neuronal activity by releasing gliotransmitters such as glutamate. In…

Systems and Control · Electrical Eng. & Systems 2023-08-21 Valentin Würzbauer , Kerstin Lenk , Matin Jafarian

Preliminary attempts at incorporating the critical role of astrocytes - cells that constitute more than 50\% of human brain cells - in brain-inspired neuromorphic computing remain in infancy. This paper seeks to delve deeper into various…

Neural and Evolutionary Computing · Computer Science 2025-08-07 Md Zesun Ahmed Mia , Malyaban Bal , Abhronil Sengupta

Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, the…

Neurons and Cognition · Quantitative Biology 2015-05-05 Maurizio De Pittà , Nicolas Brunel , Andrea Volterra

Brain activities are featured by spatially distributed neural clusters of coherent firings and a spontaneous switching of the clusters between the synchrony and asynchrony states. Evidences from {\it in vivo} experiments suggest that…

Neurons and Cognition · Quantitative Biology 2023-02-02 Ya Wang , Liang Wang , Huawei Fan , Jun Ma , Hui Cao , Xingang Wang

Mammalian brains operate in a very special surrounding: to survive they have to react quickly and effectively to the pool of stimuli patterns previously recognized as danger. Many learning tasks often encountered by living organisms involve…

Mounting evidence in recent years suggests that astrocytes, a sub-type of glial cells, not only serve metabolic and structural support for neurons and synapses but also play critical roles in regulation of proper functioning of the nervous…

Neurons and Cognition · Quantitative Biology 2022-05-18 Tugba Palabas , Andre Longtin , Dibakar Ghosh , Muhammet Uzuntarla

A mathematical model of a spiking neuron network accompanied by astrocytes is considered. The network is composed of excitatory and inhibitory neurons with synaptic connections supplied by a memristor-based model of plasticity. Another…

Neurons and Cognition · Quantitative Biology 2024-02-27 Sergey V. Stasenko , Alexey N. Mikhaylov , Alexander A. Fedotov , Vladimir A. Smirnov , Victor B. Kazantsev

Astrocytes, the most abundant type of glial cell, play a fundamental role in memory. Despite most hippocampal synapses being contacted by an astrocyte, there are no current theories that explain how neurons, synapses, and astrocytes might…

Neurons and Cognition · Quantitative Biology 2024-07-24 Leo Kozachkov , Jean-Jacques Slotine , Dmitry Krotov

The dynamics of higher-order topological signals are increasingly recognized as a key aspect of the activity of complex systems. A paradigmatic example are synaptic dynamics: synaptic efficacy changes over time driven by different…

Neurons and Cognition · Quantitative Biology 2025-07-11 Gustavo Menesse , Ana P. Millán , Joaquín J. Torres

Short-term presynaptic plasticity designates variations of the amplitude of synaptic information transfer whereby the amount of neurotransmitter released upon presynaptic stimulation changes over seconds as a function of the neuronal firing…

Neurons and Cognition · Quantitative Biology 2011-12-06 Maurizio De Pittà , Vladislav Volman , Hugues Berry , Eshel Ben-Jacob

Modeling the neuronal processes underlying short-term working memory remains the focus of many theoretical studies in neuroscience. Here we propose a mathematical model of spiking neuron network (SNN) demonstrating how a piece of…

Neurons and Cognition · Quantitative Biology 2021-09-01 Yuliya Tsybina , Innokentiy Kastalskiy , Mikhail Krivonosov , Alexey Zaikin , Victor Kazantsev , Alexander Gorban , Susanna Gordleeva

We propose a new mean-field model of brain rhythms governed by astrocytes. This theoretical framework describes how astrocytes can regulate neuronal activity and contribute to the generation of brain rhythms. The model describes at the…

Neurons and Cognition · Quantitative Biology 2024-05-07 Sergey V. Stasenko , Sergey M. Olenin , Eugene A. Grines , Tatiana A. Levanova

The investigation of the neuronal environment allows us to better understand the activity of a cerebral region as a whole. The recent experimental evidences of the presence of transporters for glutamate and GABA in both neuronal and…

Neurons and Cognition · Quantitative Biology 2015-10-07 Aurélie Garnier , Alexandre Vidal , Habib Benali

Astrocytes play a central role in inducing concerted phase synchronized neural-wave patterns inside the brain. In this article, we demonstrate that injected radio-frequency signal in underlying heavy metal layer of spin-orbit torque…

Emerging Technologies · Computer Science 2021-09-17 Umang Garg , Kezhou Yang , Abhronil Sengupta

Deciphering the complex interactions between neurotransmission and astrocytic $Ca^{2+}$ elevations is a target promising a comprehensive understanding of brain function. While the astrocytic response to excitatory synaptic activity has been…

Cell Behavior · Quantitative Biology 2019-03-19 Ioannis E. Polykretis , Vladimir A. Ivanov , Konstantinos P. Michmizos
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