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Single-cell RNA-sequencing (scRNA-seq) has become a routinely used technique to quantify the gene expression profile of thousands of single cells simultaneously. Analysis of scRNA-seq data plays an important role in the study of cell states…

Genomics · Quantitative Biology 2022-10-13 Matthew Brendel , Chang Su , Zilong Bai , Hao Zhang , Olivier Elemento , Fei Wang

Models need to be trained with privacy-preserving learning algorithms to prevent leakage of possibly sensitive information contained in their training data. However, canonical algorithms like differentially private stochastic gradient…

Machine Learning · Computer Science 2022-10-06 Yannis Cattan , Christopher A. Choquette-Choo , Nicolas Papernot , Abhradeep Thakurta

Split learning (SL) aims to protect user data privacy by distributing deep models between client-server and keeping private data locally. Only processed or `smashed' data can be transmitted from the clients to the server during the SL…

Cryptography and Security · Computer Science 2024-10-17 Ngoc Duy Pham , Khoa Tran Phan , Naveen Chilamkurti

Modern deep learning techniques focus on extracting intricate information from data to achieve accurate predictions. However, the training datasets may be crowdsourced and include sensitive information, such as personal contact details,…

Machine Learning · Statistics 2026-02-10 Zhongjie Shi , Puyu Wang , Chenyang Zhang , Yuan Cao

Deep neural networks (DNNs) offer a means of addressing the challenging task of clustering high-dimensional data. DNNs can extract useful features, and so produce a lower dimensional representation, which is more amenable to clustering…

Machine Learning · Computer Science 2021-07-23 Louis Mahon , Thomas Lukasiewicz

Deep neural networks often use large, high-quality datasets to achieve high performance on many machine learning tasks. When training involves potentially sensitive data, this process can raise privacy concerns, as large models have been…

Machine Learning · Computer Science 2025-06-23 Felix Zhou , Samson Zhou , Vahab Mirrokni , Alessandro Epasto , Vincent Cohen-Addad

Deep learning models leak significant amounts of information about their training datasets. Previous work has investigated training models with differential privacy (DP) guarantees through adding DP noise to the gradients. However, such…

Machine Learning · Computer Science 2020-07-23 Milad Nasr , Reza Shokri , Amir houmansadr

The integration of Differential Privacy (DP) with diffusion models (DMs) presents a promising yet challenging frontier, particularly due to the substantial memorization capabilities of DMs that pose significant privacy risks. Differential…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Yu-Lin Tsai , Yizhe Li , Zekai Chen , Po-Yu Chen , Chia-Mu Yu , Xuebin Ren , Francois Buet-Golfouse

Privacy protection is a crucial issue in machine learning algorithms, and the current privacy protection is combined with traditional artificial neural networks based on real values. Spiking neural network (SNN), the new generation of…

Neural and Evolutionary Computing · Computer Science 2023-04-12 Jihang Wang , Dongcheng Zhao , Guobin Shen , Qian Zhang , Yi Zeng

Machine learning (ML) models have been shown to leak private information from their training datasets. Differential Privacy (DP), typically implemented through the differential private stochastic gradient descent algorithm (DP-SGD), has…

Machine Learning · Computer Science 2025-02-17 Dariush Wahdany , Matthew Jagielski , Adam Dziedzic , Franziska Boenisch

Differentially private stochastic gradient descent (DP-SGD) enables private deep learning through per-example clipping and calibrated Gaussian noise, but its high-variance updates can reduce utility on challenging datasets. We propose…

Machine Learning · Computer Science 2026-05-21 Mohammad Partohaghighi , Roummel Marcia

Generative Adversarial Networks (GANs) are one of the well-known models to generate synthetic data including images, especially for research communities that cannot use original sensitive datasets because they are not publicly accessible.…

Machine Learning · Computer Science 2020-01-28 Reihaneh Torkzadehmahani , Peter Kairouz , Benedict Paten

Training generative models with differential privacy (DP) typically involves injecting noise into gradient updates or adapting the discriminator's training procedure. As a result, such approaches often struggle with hyper-parameter tuning…

Machine Learning · Computer Science 2024-10-29 Kristjan Greenewald , Yuancheng Yu , Hao Wang , Kai Xu

In the domain of deep learning, the challenge of protecting sensitive data while maintaining model utility is significant. Traditional Differential Privacy (DP) techniques such as Differentially Private Stochastic Gradient Descent (DP-SGD)…

Machine Learning · Computer Science 2024-11-06 Tao Huang , Qingyu Huang , Xin Shi , Jiayang Meng , Guolong Zheng , Xu Yang , Xun Yi

Differential privacy (DP) is a formal privacy framework that enables training machine learning (ML) models while protecting individuals' data. As pointed out by prior work, ML models are part of larger systems, which can lead to so-called…

Machine Learning · Computer Science 2026-04-27 Marlon Tobaben , Talal Alrawajfeh , Marcus Klasson , Mikko Heikkilä , Arno Solin , Antti Honkela

Deep Neural Network (DNN) has been showing great potential in kinds of real-world applications such as fraud detection and distress prediction. Meanwhile, data isolation has become a serious problem currently, i.e., different parties cannot…

Machine Learning · Computer Science 2020-03-13 Longfei Zheng , Chaochao Chen , Yingting Liu , Bingzhe Wu , Xibin Wu , Li Wang , Lei Wang , Jun Zhou , Shuang Yang

Deep Neural Networks (DNNs) have achieved remarkable progress in various real-world applications, especially when abundant training data are provided. However, data isolation has become a serious problem currently. Existing works build…

Machine Learning · Computer Science 2022-02-22 Jun Zhou , Longfei Zheng , Chaochao Chen , Yan Wang , Xiaolin Zheng , Bingzhe Wu , Cen Chen , Li Wang , Jianwei Yin

Differentially-Private SGD (DP-SGD) and its adaptive variant DP-Adam are powerful techniques to protect user privacy when using sensitive data to train neural networks. During training, converting model weights and activations into…

Machine Learning · Computer Science 2026-04-17 Yubo Gao , Renbo Tu , Gennady Pekhimenko , Nandita Vijaykumar

We propose a novel Decentralized Differentially Private Power Method (D-DP-PM) for performing Principal Component Analysis (PCA) in networked multi-agent settings. Unlike conventional decentralized PCA approaches where each agent accesses…

Machine Learning · Computer Science 2025-07-31 Andrew Campbell , Anna Scaglione , Sean Peisert

The application of differential privacy to the training of deep neural networks holds the promise of allowing large-scale (decentralized) use of sensitive data while providing rigorous privacy guarantees to the individual. The predominant…

Machine Learning · Computer Science 2021-08-11 Moritz Knolle , Dmitrii Usynin , Alexander Ziller , Marcus R. Makowski , Daniel Rueckert , Georgios Kaissis