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This paper considers the use of Machine Learning (ML) in medicine by focusing on the main problem that this computational approach has been aimed at solving or at least minimizing: uncertainty. To this aim, we point out how uncertainty is…

Machine Learning · Computer Science 2018-05-15 Federico Cabitza , Davide Ciucci , Raffaele Rasoini

When deploying machine learning models in high-stakes real-world environments such as health care, it is crucial to accurately assess the uncertainty concerning a model's prediction on abnormal inputs. However, there is a scarcity of…

Machine Learning · Computer Science 2020-11-20 Dennis Ulmer , Lotta Meijerink , Giovanni Cinà

Machine Learning (ML) models have gained popularity in medical imaging analysis given their expert level performance in many medical domains. To enhance the trustworthiness, acceptance, and regulatory compliance of medical imaging models…

Human-Computer Interaction · Computer Science 2025-06-06 Mischa Dombrowski , Andrea Prenner , Bernhard Kainz

Would you trust physicians if they cannot explain their decisions to you? Medical diagnostics using machine learning gained enormously in importance within the last decade. However, without further enhancements many state-of-the-art machine…

Machine Learning · Computer Science 2022-06-01 Emanuel Slany , Yannik Ott , Stephan Scheele , Jan Paulus , Ute Schmid

Medical image classification is a critical problem for healthcare, with the potential to alleviate the workload of doctors and facilitate diagnoses of patients. However, two challenges arise when deploying deep learning models to real-world…

Computer Vision and Pattern Recognition · Computer Science 2023-10-06 An Yan , Yu Wang , Yiwu Zhong , Zexue He , Petros Karypis , Zihan Wang , Chengyu Dong , Amilcare Gentili , Chun-Nan Hsu , Jingbo Shang , Julian McAuley

A significant proportion of clinical physiologic monitoring alarms are false. This often leads to alarm fatigue in clinical personnel, inevitably compromising patient safety. To combat this issue, researchers have attempted to build Machine…

Machine Learning · Computer Science 2022-06-22 Arnab Dey , Mononito Goswami , Joo Heung Yoon , Gilles Clermont , Michael Pinsky , Marilyn Hravnak , Artur Dubrawski

Machine learning for early prediction in medicine has recently shown breakthrough performance, however, the focus on improving prediction accuracy has led to a neglect of faithful explanations that are required to gain the trust of medical…

Computation and Language · Computer Science 2025-12-04 Michael Staniek , Artem Sokolov , Stefan Riezler

Machine learning-based medical anomaly detection is an important problem that has been extensively studied. Numerous approaches have been proposed across various medical application domains and we observe several similarities across these…

Machine Learning · Computer Science 2021-04-14 Tharindu Fernando , Harshala Gammulle , Simon Denman , Sridha Sridharan , Clinton Fookes

Medicine and deep learning-based artificial intelligence (AI) engineering represent two distinct fields each with decades of published history. With such history comes a set of terminology that has a specific way in which it is applied.…

Supervised learning is ubiquitous in medical image analysis. In this paper we consider the problem of meta-learning -- predicting which methods will perform well in an unseen classification problem, given previous experience with other…

Computer Vision and Pattern Recognition · Computer Science 2017-06-13 Veronika Cheplygina , Pim Moeskops , Mitko Veta , Behdad Dasht Bozorg , Josien Pluim

Real-world data is often incomplete and contains missing values. To train accurate models over real-world datasets, users need to spend a substantial amount of time and resources imputing and finding proper values for missing data items. In…

Machine Learning · Statistics 2024-03-05 Cheng Zhen , Nischal Aryal , Arash Termehchy , Alireza Aghasi , Amandeep Singh Chabada

Although machine learning (ML) models of AI achieve high performances in medicine, they are not free of errors. Empowering clinicians to identify incorrect model recommendations is crucial for engendering trust in medical AI. Explainable AI…

Artificial Intelligence · Computer Science 2022-12-20 Isil Guzey , Ozlem Ucar , Nukhet Aladag Ciftdemir , Betul Acunas

In this paper we present a heuristic method to provide individual explanations for those elements in a dataset (data points) which are wrongly predicted by a given classifier. Since the general case is too difficult, in the present work we…

Machine Learning · Computer Science 2023-02-21 Sheng Zhou , Pierre Blanchart , Michel Crucianu , Marin Ferecatu

Common machine learning settings range from supervised tasks, where accurately labeled data is accessible, through semi-supervised and weakly-supervised tasks, where target labels are scant or noisy, to unsupervised tasks where labels are…

Machine Learning · Computer Science 2025-04-22 Yogev Kriger , Shai Fine

Real-world applications of machine learning models are often subject to legal or policy-based regulations. Some of these regulations require ensuring the validity of the model, i.e., the approximation error being smaller than a threshold. A…

Machine Learning · Statistics 2024-06-18 Sven Lämmle , Can Bogoclu , Robert Voßhall , Anselm Haselhoff , Dirk Roos

The use of deep learning for medical imaging has seen tremendous growth in the research community. One reason for the slow uptake of these systems in the clinical setting is that they are complex, opaque and tend to fail silently. Outside…

Computer Vision and Pattern Recognition · Computer Science 2018-07-03 Terrance DeVries , Graham W. Taylor

The development of medical science greatly depends on the increased utilization of machine learning algorithms. By incorporating machine learning, the medical imaging field can significantly improve in terms of the speed and accuracy of the…

Image and Video Processing · Electrical Eng. & Systems 2024-09-01 Angona Biswas , MD Abdullah Al Nasim , Md Shahin Ali , Ismail Hossain , Md Azim Ullah , Sajedul Talukder

Many safety failures in machine learning arise when models are used to assign predictions to people (often in settings like lending, hiring, or content moderation) without accounting for how individuals can change their inputs. In this…

Machine Learning · Computer Science 2025-07-04 Seung Hyun Cheon , Meredith Stewart , Bogdan Kulynych , Tsui-Wei Weng , Berk Ustun

Despite the recent improvements in overall accuracy, deep learning systems still exhibit low levels of robustness. Detecting possible failures is critical for a successful clinical integration of these systems, where each data point…

Image and Video Processing · Electrical Eng. & Systems 2019-10-14 Alain Jungo , Mauricio Reyes

In the AutoML domain, test accuracy is heralded as the quintessential metric for evaluating model efficacy, underpinning a wide array of applications from neural architecture search to hyperparameter optimization. However, the reliability…

Machine Learning · Computer Science 2024-09-24 Pawel Pukowski , Haiping Lu