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Sparse auto-encoders (SAEs) have re-emerged as a prominent method for mechanistic interpretability, yet they face two significant challenges: the non-smoothness of the $L_1$ penalty, which hinders reconstruction and scalability, and a lack…

Artificial Intelligence · Computer Science 2026-05-19 Ouns El Harzli , Hugo Wallner , Yoonsoo Nam , Haixuan Xavier Tao

We present Universal Sparse Autoencoders (USAEs), a framework for uncovering and aligning interpretable concepts spanning multiple pretrained deep neural networks. Unlike existing concept-based interpretability methods, which focus on a…

Computer Vision and Pattern Recognition · Computer Science 2026-03-20 Harrish Thasarathan , Julian Forsyth , Thomas Fel , Matthew Kowal , Konstantinos G. Derpanis

Sparse Autoencoders (SAEs) are a powerful dictionary learning technique for decomposing neural network activations, translating the hidden state into human ideas with high semantic value despite no external intervention or guidance.…

Machine Learning · Computer Science 2025-12-17 Albert Miao , Chenliang Zhou , Jiawei Zhou , Cengiz Oztireli

Motivation: Predicting cellular responses to genetic perturbations is essential for understanding biological systems and developing targeted therapeutic strategies. While variational autoencoders (VAEs) have shown promise in modeling…

Machine Learning · Computer Science 2025-02-03 Seungheun Baek , Soyon Park , Yan Ting Chok , Mogan Gim , Jaewoo Kang

The combination of machine learning models with physical models is a recent research path to learn robust data representations. In this paper, we introduce p$^3$VAE, a variational autoencoder that integrates prior physical knowledge about…

Computer Vision and Pattern Recognition · Computer Science 2025-02-27 Romain Thoreau , Laurent Risser , Véronique Achard , Béatrice Berthelot , Xavier Briottet

Sparse autoencoders (SAEs) have recently emerged as a powerful tool for interpreting the internal representations of large language models (LLMs), revealing latent latent features with semantical meaning. This interpretability has also…

Other Quantitative Biology · Quantitative Biology 2025-07-11 Haoxiang Guan , Jiyan He , Jie Zhang

Learning a generative model of visual information with sparse and compositional features has been a challenge for both theoretical neuroscience and machine learning communities. Sparse coding models have achieved great success in explaining…

Machine Learning · Computer Science 2021-01-26 Linxing Preston Jiang , Luciano de la Iglesia

Sparse Autoencoders (SAEs) are an interpretability technique aimed at decomposing neural network activations into interpretable units. However, a major bottleneck for SAE development has been the lack of high-quality performance metrics,…

Machine Learning · Computer Science 2024-12-02 Adam Karvonen , Can Rager , Samuel Marks , Neel Nanda

Sparse autoencoders are usually trained one layer at a time, even though transformer residual stream activations are strongly coupled across depth. This creates a practical problem for multi-layer interventions: different layerwise…

Machine Learning · Computer Science 2026-05-28 Prathyush Poduval , Calvin Yeung , Neel Desai , Mohsen Imani

Electron, optical, and scanning probe microscopy methods are generating ever increasing volume of image data containing information on atomic and mesoscale structures and functionalities. This necessitates the development of the machine…

Machine Learning · Computer Science 2023-04-03 Mani Valleti , Yongtao Liu , Sergei Kalinin

Deep generative models have demonstrated their effectiveness in learning latent representation and modeling complex dependencies of time series. In this paper, we present a Smoothness-Inducing Sequential Variational Auto-Encoder (SISVAE)…

Machine Learning · Computer Science 2021-02-03 Longyuan Li , Junchi Yan , Haiyang Wang , Yaohui Jin

It has been long known that sparsity is an effective inductive bias for learning efficient representation of data in vectors with fixed dimensionality, and it has been explored in many areas of representation learning. Of particular…

Computation and Language · Computer Science 2021-04-20 Victor Prokhorov , Yingzhen Li , Ehsan Shareghi , Nigel Collier

While sparse autoencoders (SAEs) successfully extract interpretable features from language models, applying them to audio generation faces unique challenges: audio's dense nature requires compression that obscures semantic meaning, and…

Machine Learning · Computer Science 2025-10-31 Nathan Paek , Yongyi Zang , Qihui Yang , Randal Leistikow

Extraction of low-dimensional latent space from high-dimensional observation data is essential to construct a real-time robot controller with a world model on the extracted latent space. However, there is no established method for tuning…

Machine Learning · Computer Science 2023-07-04 Taisuke Kobayashi , Ryoma Watanuki

Recent work shows that Sparse Autoencoders (SAE) applied to large language model (LLM) layers have neurons corresponding to interpretable concepts. These SAE neurons can be modified to align generated outputs, but only towards…

Computation and Language · Computer Science 2025-07-01 Ananya Joshi , Celia Cintas , Skyler Speakman

Variational Autoencoders (VAE) are widely used for dimensionality reduction of large-scale tabular and image datasets, under the assumption of independence between data observations. In practice, however, datasets are often correlated, with…

Machine Learning · Statistics 2024-12-25 Giora Simchoni , Saharon Rosset

Elucidating the functional mechanisms of the primary visual cortex (V1) remains a fundamental challenge in systems neuroscience. Current computational models face two critical limitations, namely the challenge of cross-modal integration…

Neurons and Cognition · Quantitative Biology 2024-12-20 Yu Zhu , Bo Lei , Chunfeng Song , Wanli Ouyang , Shan Yu , Tiejun Huang

Deep neural networks often suffer from poor generalization due to complex and non-convex loss landscapes. Sharpness-Aware Minimization (SAM) is a popular solution that smooths the loss landscape by minimizing the maximized change of…

Artificial Intelligence · Computer Science 2023-07-03 Peng Mi , Li Shen , Tianhe Ren , Yiyi Zhou , Tianshuo Xu , Xiaoshuai Sun , Tongliang Liu , Rongrong Ji , Dacheng Tao

We consider the problem of modeling the effects of perturbations like gene knockouts on measurements such as single-cell RNA counts. Given data for some perturbations, we aim to predict the distribution of measurements for new combinations…

Radiological services are experiencing unprecedented demand, leading to increased interest in automating radiology report generation. Existing Vision-Language Models (VLMs) suffer from hallucinations, lack interpretability, and require…

Computer Vision and Pattern Recognition · Computer Science 2024-10-07 Ahmed Abdulaal , Hugo Fry , Nina Montaña-Brown , Ayodeji Ijishakin , Jack Gao , Stephanie Hyland , Daniel C. Alexander , Daniel C. Castro
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