English
Related papers

Related papers: Understanding the Natural Language of DNA using En…

200 papers

Decoder-based transformers, while revolutionizing language modeling and scaling to immense sizes, have not completely overtaken encoder-heavy architectures in natural language processing. Specifically, encoder-only models remain dominant in…

Computation and Language · Computer Science 2025-03-05 Paul Suganthan , Fedor Moiseev , Le Yan , Junru Wu , Jianmo Ni , Jay Han , Imed Zitouni , Enrique Alfonseca , Xuanhui Wang , Zhe Dong

Tokens serve as the basic units of representation in DNA language models (DNALMs), yet their design remains underexplored. Unlike natural language, DNA lacks inherent token boundaries or predefined compositional rules, making tokenization a…

Machine Learning · Computer Science 2026-04-13 Nan Huang , Xiaoxiao Zhou , Junxia Cui , Mario Tapia-Pacheco , Tiffany Amariuta , Yang Li , Jingbo Shang

Language models have advanced sequence analysis, yet DNA foundation models often lag behind task-specific methods for unclear reasons. We present AntigenLM, a generative DNA language model pretrained on influenza genomes with intact,…

Genomics · Quantitative Biology 2026-02-12 Yue Pei , Xuebin Chi , Yu Kang

Vision foundation models (VFMs), such as DINOv3, provide rich semantic representations that are promising for computational pathology. However, many current adaptations pair frozen VFMs with lightweight decoders, creating a capacity…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Tianyang Wang , Ziyu Su , Abdul Rehman Akbar , Usama Sajjad , Usman Afzaal , Lina Gokhale , Charles Rabolli , Wei Chen , Anil Parwani , Muhammad Khalid Khan Niazi

We introduce a protein language model for determining the complete sequence of a peptide based on measurement of a limited set of amino acids. To date, protein sequencing relies on mass spectrometry, with some novel edman degregation based…

State-of-the-art neural models typically encode document-query pairs using cross-attention for re-ranking. To this end, models generally utilize an encoder-only (like BERT) paradigm or an encoder-decoder (like T5) approach. These paradigms,…

Computation and Language · Computer Science 2022-04-26 Kai Hui , Honglei Zhuang , Tao Chen , Zhen Qin , Jing Lu , Dara Bahri , Ji Ma , Jai Prakash Gupta , Cicero Nogueira dos Santos , Yi Tay , Don Metzler

We present a novel unsupervised deep learning approach that utilizes the encoder-decoder architecture for detecting anomalies in sequential sensor data collected during industrial manufacturing. Our approach is designed not only to detect…

Ever-larger language models with ever-increasing capabilities are by now well-established text processing tools. Alas, information extraction tasks such as named entity recognition are still largely unaffected by this progress as they are…

Computation and Language · Computer Science 2023-08-16 Tobias Deußer , Lars Hillebrand , Christian Bauckhage , Rafet Sifa

DNA language models are increasingly used to represent genomic sequence, yet their effectiveness depends critically on how raw nucleotides are converted into model inputs. Unlike natural language, DNA offers no canonical boundaries, making…

Genomics · Quantitative Biology 2026-05-21 Taewon Kim , Jihwan Shin , Hyomin Kim , Youngmok Jung , Jonghoon Lee , Won-Chul Lee , Sungsoo Ahn , Insu Han

Machine comprehension(MC) style question answering is a representative problem in natural language processing. Previous methods rarely spend time on the improvement of encoding layer, especially the embedding of syntactic information and…

Artificial Intelligence · Computer Science 2017-07-31 Boyuan Pan , Hao Li , Zhou Zhao , Bin Cao , Deng Cai , Xiaofei He

The paper presents a method for spoken term detection based on the Transformer architecture. We propose the encoder-encoder architecture employing two BERT-like encoders with additional modifications, including convolutional and upsampling…

Computation and Language · Computer Science 2022-11-03 Jan Švec , Luboš Šmídl , Jan Lehečka

Vision-language pre-training has been an emerging and fast-developing research topic, which transfers multi-modal knowledge from rich-resource pre-training task to limited-resource downstream tasks. Unlike existing works that predominantly…

Computer Vision and Pattern Recognition · Computer Science 2022-01-12 Yehao Li , Jiahao Fan , Yingwei Pan , Ting Yao , Weiyao Lin , Tao Mei

The genome sequence contains the blueprint for governing cellular processes. While the availability of genomes has vastly increased over the last decades, experimental annotation of the various functional, non-coding and regulatory elements…

Genomics · Quantitative Biology 2024-04-10 Frederikke Isa Marin , Felix Teufel , Marc Horlacher , Dennis Madsen , Dennis Pultz , Ole Winther , Wouter Boomsma

Large-scale pre-training methodologies for chemical language models represent a breakthrough in cheminformatics. These methods excel in tasks such as property prediction and molecule generation by learning contextualized representations of…

Machine Learning · Computer Science 2025-07-18 Eduardo Soares , Victor Shirasuna , Emilio Vital Brazil , Renato Cerqueira , Dmitry Zubarev , Kristin Schmidt

DNA sequence alignment involves assigning short DNA reads to the most probable locations on an extensive reference genome. This process is crucial for various genomic analyses, including variant calling, transcriptomics, and epigenomics.…

Gene enhancers control when and where genes switch on, yet their sequence diversity and tissue specificity make them hard to pinpoint in colorectal cancer. We take a sequence-only route and fine-tune DNABERT-2, a transformer genomic…

Genomics · Quantitative Biology 2025-10-01 Darren King , Yaser Atlasi , Gholamreza Rafiee

Currently, many studies view DNA sequences as a special type of language and utilize Transformers to model them. These studies use fixed-length k-mer segmentation and BPE subword tokenization but lack a systematic evaluation to determine…

Computation and Language · Computer Science 2025-07-22 Chenlei Gong , Yuanhe Tian , Lei Mao , Yan Song

High-quality speech corpora are essential foundations for most speech applications. However, such speech data are expensive and limited since they are collected in professional recording environments. In this work, we propose an…

Audio and Speech Processing · Electrical Eng. & Systems 2020-11-11 Haoyu Li , Yang Ai , Junichi Yamagishi

The success of foundation AI has motivated the research of circuit foundation models, which are customized to assist the integrated circuit (IC) design process. However, existing pre-trained circuit foundation models are typically limited…

Machine Learning · Computer Science 2025-08-07 Wenji Fang , Jing Wang , Yao Lu , Shang Liu , Zhiyao Xie

Electroencephalography (EEG) foundation models hold significant promise for universal Brain-Computer Interfaces (BCIs). However, existing approaches often rely on end-to-end fine-tuning and exhibit limited efficacy under frozen-probing…

Machine Learning · Computer Science 2026-03-20 Jiquan Wang , Sha Zhao , Yangxuan Zhou , Yiming Kang , Shijian Li , Gang Pan