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Time-of-flight positron emission tomography (TOF-PET) detectors exhibiting multiple coincidence time resolution (CTR) components, such as those induced by the mixing of Cherenkov and scintillation photons, have attracted increasing…

Medical Physics · Physics 2026-05-29 Kibo Ote , Fumio Hashimoto , Yuya Onishi , Ryosuke Ota , Maxime Toussaint , Francis Loignon-Houle

Low-count PET is an efficient way to reduce radiation exposure and acquisition time, but the reconstructed images often suffer from low signal-to-noise ratio (SNR), thus affecting diagnosis and other downstream tasks. Recent advances in…

Image and Video Processing · Electrical Eng. & Systems 2023-10-09 Bo Zhou , Huidong Xie , Qiong Liu , Xiongchao Chen , Xueqi Guo , Zhicheng Feng , Jun Hou , S. Kevin Zhou , Biao Li , Axel Rominger , Kuangyu Shi , James S. Duncan , Chi Liu

Positron range (PR) blurring degrades positron emission tomography (PET) image resolution, particularly for high-energy emitters like gallium-68 (68 Ga). We introduce Dual-Input Dynamic Convolution (DDConv), a novel computationally…

In Fluorescein Angiography (FA), an exogenous dye is injected in the bloodstream to image the vascular structure of the retina. The injected dye can cause adverse reactions such as nausea, vomiting, anaphylactic shock, and even death. In…

Image and Video Processing · Electrical Eng. & Systems 2022-05-02 Sharif Amit Kamran , Khondker Fariha Hossain , Alireza Tavakkoli , Stewart Lee Zuckerbrod , Salah A. Baker

People with diabetes are at risk of developing an eye disease called diabetic retinopathy (DR). This disease occurs when high blood glucose levels cause damage to blood vessels in the retina. Computer-aided DR diagnosis is a promising tool…

Computer Vision and Pattern Recognition · Computer Science 2020-11-12 Yi Zhou , Boyang Wang , Lei Huang , Shanshan Cui , Ling Shao

PET imaging is widely employed for observing biological metabolic activities within the human body. However, numerous benign conditions can cause increased uptake of radiopharmaceuticals, confounding differentiation from malignant tumors.…

Image and Video Processing · Electrical Eng. & Systems 2024-10-31 Ran Hong , Yuxia Huang , Lei Liu , Zhonghui Wu , Bingxuan Li , Xuemei Wang , Qiegen Liu

Multi-tracer positron emission tomography (PET) provides critical insights into diverse neuropathological processes such as tau accumulation, neuroinflammation, and $\beta$-amyloid deposition in the brain, making it indispensable for…

Image and Video Processing · Electrical Eng. & Systems 2026-02-26 Minhui Yu , Yongheng Sun , David S. Lalush , Jason P Mihalik , Pew-Thian Yap , Mingxia Liu

Reconstruction of PET images is an ill-posed inverse problem and often requires iterative algorithms to achieve good image quality for reliable clinical use in practice, at huge computational costs. In this paper, we consider the PET…

Computer Vision and Pattern Recognition · Computer Science 2017-04-25 Jieqing Jiao , Sebastien Ourselin

Medical imaging datasets are inherently high dimensional with large variability and low sample sizes that limit the effectiveness of deep learning algorithms. Recently, generative adversarial networks (GANs) with the ability to synthesize…

Image and Video Processing · Electrical Eng. & Systems 2024-12-13 Apoorva Sikka , Skand Peri , Jitender Singh Virk , Usma Niyaz , Deepti R. Bathula

Positron Emission Tomography (PET) enables functional imaging of deep brain structures, but the bulk and weight of current systems preclude their use during many natural human activities, such as locomotion. The proposed long-term solution…

Robotics · Computer Science 2023-12-07 Junxiang Wang , Ti Wu , Iulian I. Iordachita , Peter Kazanzides

Deep-learning (DL)-based image deconvolution (ID) has exhibited remarkable recovery performance, surpassing traditional linear methods. However, unlike traditional ID approaches that rely on analytical properties of the point spread…

Image and Video Processing · Electrical Eng. & Systems 2025-01-28 Romario Gualdrón-Hurtado , Roman Jacome , Sergio Urrea , Henry Arguello , Luis Gonzalez

Deep learning has significantly advanced PET image re-construction, achieving remarkable improvements in image quality through direct training on sinogram or image data. Traditional methods often utilize masks for inpainting tasks, but…

Computer Vision and Pattern Recognition · Computer Science 2025-03-12 Bin Huang , Binzhong He , Yanhan Chen , Zhili Liu , Xinyue Wang , Binxuan Li , Qiegen Liu

We are investigating a prototype virtual pinhole positron emission tomography (VP-PET) system for small animal imaging applications. The PET detector modules were made up of 1.3 mm lutetium-yttrium oxyorthosilicate (LYSO) arrays, and the…

Medical Physics · Physics 2018-01-11 Zheng-Qian Ye , Ying-Guo Li , Tian-Quan Wang , Ya-Ming Fan , Yong-Zhi Yin , Xi-Meng Chen

Positron range (PR) limits spatial resolution and quantitative accuracy in PET imaging, particularly for high-energy positron-emitting radionuclides like 68Ga. We propose a deep learning method using 3D residual encoder-decoder…

We developed a positron emission tomography (PET) system for multiple-isotope imaging. Our PET system, named multiple-isotope PET (MI-PET), can distinguish between different tracer nuclides using coincidence measurement of prompt…

Time-of-flight (TOF) information provides more accurate location data for annihilation photons, thereby enhancing the quality of PET reconstruction images and reducing noise. List-mode reconstruction has a significant advantage in handling…

Image and Video Processing · Electrical Eng. & Systems 2024-10-16 Rui Hu , Chenxu Li , Kun Tian , Jianan Cui , Yunmei Chen , Huafeng Liu

Whole-body Positron Emission Tomography (PET) registration is essential for multi-parametric tumor characterization and assessment of metastatic disease progression. In deep learning-based deformable registration, the dense displacement…

Image and Video Processing · Electrical Eng. & Systems 2026-04-28 Xiangcen Wu , Ruohua Chen , Sichun Li , Qianye Yang , Sheng Liu , Jianjun Liu , Zhaoheng Xie

Carbon ion therapy have the ability to overcome the limitation of convertional radiotherapy due to its most energy deposition in selective depth, usually called Bragg peak, which results in increased biological effectiness. During carbon…

Dynamic positron emission tomography imaging (dPET) provides temporally resolved images of a tracer enabling a quantitative measure of physiological processes. Voxel-wise physiologically-based pharmacokinetic (PBPK) modeling of the time…

Image and Video Processing · Electrical Eng. & Systems 2023-05-19 Francesca De Benetti , Walter Simson , Magdalini Paschali , Hasan Sari , Axel Romiger , Kuangyu Shi , Nassir Navab , Thomas Wendler

Positron emission tomography (PET) offers powerful functional imaging but involves radiation exposure. Efforts to reduce this exposure by lowering the radiotracer dose or scan time can degrade image quality. While using magnetic resonance…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Yingkai Zhang , Shuang Chen , Ye Tian , Yunyi Gao , Jianyong Jiang , Ying Fu
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