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A rise in blood flow velocity variations (i.e., pulsatility) in the brain, caused by the stiffening of upstream arteries, is associated with cognitive impairment and neurodegenerative diseases. The study of this phenomenon requires…

The role of brain hemodynamics in neurodegenerative diseases cannot be fully assessed using existing imaging technologies. Recently, 2D Dynamic Ultrasound Localization Microscopy (DULM) has allowed for the quantitative mapping of the…

Ultrasound localization microscopy (ULM) enables microvascular imaging at spatial resolutions beyond the acoustic diffraction limit, offering significant clinical potentials. However, ULM performance relies heavily on microbubble (MB)…

Ultrasound Localization Microscopy (ULM) has proven effective in resolving microvascular structures and local mean velocities at sub-diffraction-limited scales, offering high-resolution imaging capabilities. Dynamic ULM (DULM) enables the…

Ultrasound Localization Microscopy (ULM) is a non-invasive technique that allows for the imaging of micro-vessels in vivo, at depth and with a resolution on the order of ten microns. ULM is based on the sub-resolution localization of…

Image and Video Processing · Electrical Eng. & Systems 2025-10-17 Brice Rauby , Paul Xing , Jonathan Porée , Maxime Gasse , Jean Provost

Ultrasound Localization Microscopy (ULM) has presented great potential in functional imaging, benefiting from its ability to reconstruct deep microvasculature. However, the hemodynamic reconstruction is compromised by sparsity in the ULM…

Image and Video Processing · Electrical Eng. & Systems 2026-05-27 Jipeng Yan , Oscar Bates , Jingwen Zhu , Qingyuan Tan , Biao Huang , John Goodwin , Andriy S. Kozlov , Chris Dunsby , Meng-Xing Tang

Ultrasound localization microscopy has enabled super-resolution vascular imaging through precise localization of individual ultrasound contrast agents (microbubbles) across numerous imaging frames. However, analysis of high-density regions…

Signal Processing · Electrical Eng. & Systems 2018-12-14 Ruud J. G. van Sloun , Oren Solomon , Matthew Bruce , Zin Z. Khaing , Hessel Wijkstra , Yonina C. Eldar , Massimo Mischi

Non-invasive detection of microvascular alterations in deep tissues in vivo provides critical information for clinical diagnosis and evaluation of a broad-spectrum of pathologies. Recently, the emergence of super-resolution ultrasound…

Three-dimensional ultrasound localization microscopy (ULM) enables comprehensive visualization of the vasculature, thereby improving diagnostic reliability. Nevertheless, its clinical translation remains challenging, as the exponential…

Convection of liquid metals drives large natural processes and is important in technical processes. Model experiments are conducted for research purposes where simulations are expensive and the clarification of open questions requires novel…

Fluid Dynamics · Physics 2024-04-18 David Weik , Zehua Dou , Dirk Räbiger , Tobias Vogt , Sven Eckert , Jürgen Czarske , Lars Büttner

Hemodynamic changes occur in stroke and neurodegenerative diseases. Developing imaging techniques allowing the in vivo visualization and quantification of cerebral blood flow would help better understand the underlying mechanism of those…

Image and Video Processing · Electrical Eng. & Systems 2024-12-24 Paul Xing , Vincent Perrot , Adan Ulises Dominguez-Vargas , Stephan Quessy , Numa Dancause , Jean Provost

Ultrasound Localization Microscopy (ULM) has recently enabled the mapping of the cerebral vasculature in vivo with a resolution ten times smaller than the wavelength used, down to ten microns. However, with frame rates up to 20.000 frames…

Medical Physics · Physics 2023-10-23 Erwan Hardy , Jonathan Poree , Hatim Belgharbi , Chloe Bourquin , Frederic Lesage , Jean Provost

Ultrasound localization microscopy (ULM) refers to a promising medical imaging modality that systematically leverages the advantages of contrast-enhanced ultrasound (CEUS) to surpass the diffraction barrier and delineate the microvascular…

Image and Video Processing · Electrical Eng. & Systems 2022-09-22 Md Ashikuzzaman , Brandon Helfield , Hassan Rivaz

Super-Resolution Ultrasound (SRUS) imaging through localising and tracking microbubbles, also known as Ultrasound Localisation Microscopy (ULM), has demonstrated significant potential for reconstructing microvasculature and flows with…

Image and Video Processing · Electrical Eng. & Systems 2025-03-26 Jipeng Yan , Qingyuan Tan , Shusei Kawara , Jingwen Zhu , Bingxue Wang , Matthieu Toulemonde , Honghai Liu , Ying Tan , Meng-Xing Tang

Ultrafast ultrasound localization microscopy (ULM), which has shown promising results in microvascular imaging, overcomes the typical trade-off between resolution and penetration depth. Combining ultrasound contrast agents and high frame…

Signal Processing · Electrical Eng. & Systems 2024-07-02 A. N. Madhavanunni , Niya Mariam Benoy , Mahesh Raveendranatha Panicker , Himanshu Shekhar

Recently, super-resolution ultrasound imaging with ultrasound localization microscopy (ULM) has received much attention. However, ULM relies on low concentrations of microbubbles in the blood vessels, ultimately resulting in long…

Contrast-Enhanced Ultra-Sound (CEUS) has become a viable method for non-invasive, dynamic visualization in medical diagnostics, yet Ultrasound Localization Microscopy (ULM) has enabled a revolutionary breakthrough by offering ten times…

Computer Vision and Pattern Recognition · Computer Science 2023-07-19 Christopher Hahne , Raphael Sznitman

Ultrasound Localization Microscopy (ULM) offers a cost-effective modality for microvascular imaging by using intravascular contrast agents (microbubbles). However, ULM has a fundamental trade-off between acquisition time and spatial…

Signal Processing · Electrical Eng. & Systems 2021-01-26 Ufuk Soylu , Yoram Bresler

Segmentation of medical images is a fundamental task with numerous applications. While MRI, CT, and PET modalities have significantly benefited from deep learning segmentation techniques, more recent modalities, like functional ultrasound…

Image and Video Processing · Electrical Eng. & Systems 2025-07-24 Hana Sebia , Thomas Guyet , Mickaël Pereira , Marco Valdebenito , Hugues Berry , Benjamin Vidal

Super-resolution ultrasound via microbubble (MB) localisation and tracking, also known as ultrasound localisation microscopy (ULM), can resolve microvasculature beyond the acoustic diffraction limit. However, significant challenges remain…

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