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Recent advances in multimodal large language models (LLMs) have enabled unified reasoning across images, audio, and video, but extending such capability to brain imaging remains largely unexplored. Bridging this gap is essential to link…

Computation and Language · Computer Science 2026-05-15 Yuxiang Wei , Yanteng Zhang , Xi Xiao , Chengxuan Qian , Tianyang Wang , Vince D. Calhoun

We present brat (brain report alignment transformer), a multi-view representation learning framework for brain magnetic resonance imaging (MRI) trained on MRIs paired with clinical reports. Brain MRIs present unique challenges due to the…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Maxime Kayser , Maksim Gridnev , Wanting Wang , Max Bain , Aneesh Rangnekar , Avijit Chatterjee , Aleksandr Petrov , Harini Veeraraghavan , Nathaniel C. Swinburne

Decoding functional magnetic resonance imaging (fMRI) signals into text has been a key challenge in the neuroscience community, with the potential to advance brain-computer interfaces and uncover deeper insights into brain mechanisms.…

Neurons and Cognition · Quantitative Biology 2025-06-10 Weikang Qiu , Zheng Huang , Haoyu Hu , Aosong Feng , Yujun Yan , Rex Ying

Recent deep learning methods for fMRI-based diagnosis have achieved promising accuracy by modeling functional connectivity networks. However, standard approaches often struggle with noisy interactions, and conventional post-hoc attribution…

Machine Learning · Computer Science 2026-02-25 Kunyu Zhang , Yanwu Yang , Jing Zhang , Xiangjie Shi , Shujian Yu

In the past few years, significant advancements were made in reconstruction of observed natural images from fMRI brain recordings using deep-learning tools. Here, for the first time, we show that dense 3D depth maps of observed 2D natural…

Computer Vision and Pattern Recognition · Computer Science 2022-03-23 Guy Gaziv , Michal Irani

Brain decoding, understood as the process of mapping brain activities to the stimuli that generated them, has been an active research area in the last years. In the case of language stimuli, recent studies have shown that it is possible to…

Computation and Language · Computer Science 2020-11-12 Nicolas Affolter , Beni Egressy , Damian Pascual , Roger Wattenhofer

Brain decoding, a pivotal field in neuroscience, aims to reconstruct stimuli from acquired brain signals, primarily utilizing functional magnetic resonance imaging (fMRI). Currently, brain decoding is confined to a per-subject-per-model…

Computer Vision and Pattern Recognition · Computer Science 2024-04-12 Shizun Wang , Songhua Liu , Zhenxiong Tan , Xinchao Wang

Visual decoding from brain signals is a key challenge at the intersection of computer vision and neuroscience, requiring methods that bridge neural representations and computational models of vision. A field-wide goal is to achieve…

Brain-related research topics in artificial intelligence have recently gained popularity, particularly due to the expansion of what multimodal architectures can do from computer vision to natural language processing. Our main goal in this…

Neurons and Cognition · Quantitative Biology 2024-10-01 Youssef Hmamouche , Ismail Chihab , Lahoucine Kdouri , Amal El Fallah Seghrouchni

Human brains exhibit highly organized multiscale neurophysiological dynamics. Understanding those dynamic changes and the neuronal networks involved is critical for understanding how the brain functions in health and disease. Functional…

Neurons and Cognition · Quantitative Biology 2024-09-09 Manuel Morante , Kristian Frølich , Naveed ur Rehman

Aggregating multi-subject functional magnetic resonance imaging (fMRI) data is indispensable for generating valid and general inferences from patterns distributed across human brains. The disparities in anatomical structures and functional…

Machine Learning · Computer Science 2019-11-20 Weida Li , Mingxia Liu , Fang Chen , Daoqiang Zhang

The dispute of how the human brain represents conceptual knowledge has been argued in many scientific fields. Brain imaging studies have shown that the spatial patterns of neural activation in the brain are correlated with thinking about…

Neurons and Cognition · Quantitative Biology 2018-06-15 Subba Reddy Oota , Naresh Manwani , Bapi Raju S

Diffusion-weighted Magnetic Resonance Imaging (dMRI) is an essential tool in neuroimaging. It is arguably the sole noninvasive technique for examining the microstructural properties and structural connectivity of the brain. Recent years…

Image and Video Processing · Electrical Eng. & Systems 2025-03-13 Tianyuan Yao , Zhiyuan Li , Praitayini Kanakaraj , Derek B. Archer , Kurt Schilling , Lori Beason-Held , Susan Resnick , Bennett A. Landman , Yuankai Huo

Deep learning associated with neurological signals is poised to drive major advancements in diverse fields such as medical diagnostics, neurorehabilitation, and brain-computer interfaces. The challenge in harnessing the full potential of…

Signal Processing · Electrical Eng. & Systems 2024-07-08 Di Wu , Siyuan Li , Jie Yang , Mohamad Sawan

Deep learning models have shown their advantage in many different tasks, including neuroimage analysis. However, to effectively train a high-quality deep learning model, the aggregation of a significant amount of patient information is…

Machine Learning · Computer Science 2020-12-08 Xiaoxiao Li , Yufeng Gu , Nicha Dvornek , Lawrence Staib , Pamela Ventola , James S. Duncan

Functional magnetic resonance imaging (fMRI) has provided invaluable insight into our understanding of human behavior. However, large inter-individual differences in both brain anatomy and functional localization after anatomical alignment…

Applications · Statistics 2021-11-03 Guoqing Wang , Abhirup Datta , Martin A. Lindquist

Decoding language information from brain signals represents a vital research area within brain-computer interfaces, particularly in the context of deciphering the semantic information from the fMRI signal. However, many existing efforts…

Human-Computer Interaction · Computer Science 2024-05-14 Xiaoyu Chen , Changde Du , Che Liu , Yizhe Wang , Huiguang He

Structural magnetic resonance imaging (sMRI) provides accurate estimates of the brain's structural organization and learning invariant brain representations from sMRI is an enduring issue in neuroscience. Previous deep representation…

Computer Vision and Pattern Recognition · Computer Science 2023-06-21 Ning Jiang , Gongshu Wang , Tianyi Yan

Decoding visual experiences from fMRI offers a powerful avenue to understand human perception and develop advanced brain-computer interfaces. However, current progress often prioritizes maximizing reconstruction fidelity while overlooking…

Machine Learning · Computer Science 2025-10-09 Yuxiang Wei , Yanteng Zhang , Xi Xiao , Tianyang Wang , Xiao Wang , Vince D. Calhoun

Learning a robust Variational Autoencoder (VAE) is a fundamental step for many deep learning applications in medical image analysis, such as MRI synthesizes. Existing brain VAEs predominantly focus on single-modality data (i.e., T1-weighted…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Mingjie Li , Edward Kim , Yue Zhao , Ehsan Adeli , Kilian M. Pohl