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A new approach to adaptive design of clinical trials is proposed in a general multiparameter exponential family setting, based on generalized likelihood ratio statistics and optimal sequential testing theory. These designs are easy to…

Statistics Theory · Mathematics 2011-05-25 Jay Bartroff , Tze Leung Lai

We expand the scope of the statistical notion of error probability, i.e., how often large deviations are observed in an experiment, in order to make it directly applicable to quantum tomography. We verify that the error probability can…

Quantum Physics · Physics 2011-01-24 Takanori Sugiyama , Peter S. Turner , Mio Murao

A number of biomedical problems require performing many hypothesis tests, with an attendant need to apply stringent thresholds. Often the data take the form of a series of predictor vectors, each of which must be compared with a single…

Methodology · Statistics 2014-05-13 Yi-Hui Zhou , Fred Wright

This paper presents a simple yet efficient method for statistical inference of tensor linear forms using incomplete and noisy observations. Under the Tucker low-rank tensor model and the missing-at-random assumption, we utilize an…

Statistics Theory · Mathematics 2024-11-04 Wanteng Ma , Dong Xia

High-dimensional statistical inference with general estimating equations are challenging and remain less explored. In this paper, we study two problems in the area: confidence set estimation for multiple components of the model parameters,…

Methodology · Statistics 2021-04-28 Jinyuan Chang , Song Xi Chen , Cheng Yong Tang , Tong Tong Wu

Sequential hypothesis testing asks for decision rules that update as data arrive. A natural goal is \emph{eventual correctness}: the rule may change its mind early on, but it should make only finitely many wrong decisions almost surely.…

Information Theory · Computer Science 2026-05-05 Amir Leshem

Score-based statistical models play an important role in modern machine learning, statistics, and signal processing. For hypothesis testing, a score-based hypothesis test is proposed in \cite{wu2022score}. We analyze the performance of this…

Signal Processing · Electrical Eng. & Systems 2024-02-06 Enmao Diao , Taposh Banerjee , Vahid Tarokh

A central question in computer science and statistics is whether efficient algorithms can achieve the information-theoretic limits of statistical problems. Many computational-statistical tradeoffs have been shown under average-case…

Computational Complexity · Computer Science 2025-07-18 Guy Blanc , Caleb Koch , Carmen Strassle , Li-Yang Tan

Researchers currently use a number of approaches to predict and substantiate information-computation gaps in high-dimensional statistical estimation problems. A prominent approach is to characterize the limits of restricted models of…

Computational Complexity · Computer Science 2021-06-29 Matthew Brennan , Guy Bresler , Samuel B. Hopkins , Jerry Li , Tselil Schramm

Recall the classical hypothesis testing setting with two convex sets of probability distributions P and Q. One receives either n i.i.d. samples from a distribution p in P or from a distribution q in Q and wants to decide from which set the…

Information Theory · Computer Science 2020-07-20 Fernando G. S. L. Brandao , Aram W. Harrow , James R. Lee , Yuval Peres

In this paper, we consider the sphericity test for a one-sample problem under high-dimensional two-step monotone incomplete data. Existing asymptotic expansions for the null distributions of the likelihood ratio test (LRT) statistic and…

Statistics Theory · Mathematics 2026-04-01 Tetsuya Sato , Tomoyuki Nakagawa

This study develops a framework for testing hypotheses on structural parameters in incomplete models. Such models make set-valued predictions and hence do not generally yield a unique likelihood function. The model structure, however,…

Econometrics · Economics 2019-12-03 Hiroaki Kaido , Yi Zhang

We study the fundamental limits of detecting the presence of an additive rank-one perturbation, or spike, to a Wigner matrix. When the spike comes from a prior that is i.i.d. across coordinates, we prove that the log-likelihood ratio of the…

Probability · Mathematics 2020-06-11 Ahmed El Alaoui , Florent Krzakala , Michael I. Jordan

In large-scale hypothesis testing, computing exact $p$-values or $e$-values is often resource-intensive, creating a need for budget-aware inferential methods. We propose a general framework for active hypothesis testing that leverages…

Methodology · Statistics 2026-04-09 Qi Kuang , Bowen Gang , Yin Xia

The asymptotically optimal hypothesis testing problem with the general sources as the null and alternative hypotheses is studied under exponential-type error constraints on the first kind of error probability. Our fundamental philosophy in…

Probability · Mathematics 2007-05-23 Te Sun Han

We study the fundamental tradeoffs between statistical accuracy and computational tractability in the analysis of high dimensional heterogeneous data. As examples, we study sparse Gaussian mixture model, mixture of sparse linear…

Statistics Theory · Mathematics 2018-08-22 Jianqing Fan , Han Liu , Zhaoran Wang , Zhuoran Yang

We consider the question of learning the natural parameters of a $k$ parameter minimal exponential family from i.i.d. samples in a computationally and statistically efficient manner. We focus on the setting where the support as well as the…

Machine Learning · Computer Science 2021-11-01 Abhin Shah , Devavrat Shah , Gregory W. Wornell

Traditional hypothesis tests for differences between binomial proportions are at risk of being too liberal (Wald test) or overly conservative (Fisher's exact test). This problem is exacerbated in small samples. Regulators favour exact…

Methodology · Statistics 2025-07-31 Stef Baas , Yaron Racah , Elad Berkman , Sofia S. Villar

We develop, discuss, and compare several inference techniques to constrain theory parameters in collider experiments. By harnessing the latent-space structure of particle physics processes, we extract extra information from the simulator.…

High Energy Physics - Phenomenology · Physics 2018-09-19 Johann Brehmer , Kyle Cranmer , Gilles Louppe , Juan Pavez

We study finite-sample inference for the trade-off function of two unknown probability distributions, the function that traces the optimal type I/type II error frontier in binary testing. Given samples from distributions $P$ and $Q$, we…

Statistics Theory · Mathematics 2026-05-12 Kaining Shi , Qiaosen Wang , Cong Ma