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Stochastic simulation methods can be applied successfully to model exact spatio-temporally resolved reaction-diffusion systems. However, in many cases, these methods can quickly become extremely computationally intensive with increasing…

Quantitative Methods · Quantitative Biology 2016-04-29 Jonathan U. Harrison , Christian A. Yates

In this paper we consider large state space continuous time Markov chains (MCs) arising in the field of systems biology. For density dependent families of MCs that represent the interaction of large groups of identical objects, Kurtz has…

Performance · Computer Science 2015-03-04 Alessio Angius , Gianfranco Balbo , Marco Beccuti , Enrico Bibbona , Andras Horvath , Roberta Sirovich

Time evolution in several classes of quantum devices is generated through the application of quantum gates. Resetting is a critical technological feature in these systems allowing for mid-circuit measurement and complete or partial qubit…

Quantum Physics · Physics 2025-05-14 Sascha Wald , Louie Hong Yao , Thierry Platini , Chris Hooley , Federico Carollo

Due to inherent noise in intracellular networks cellular decisions can be random, so genetically identical cells can display different phenotypic behavior even in identical environments. Most previous work in understanding the…

Molecular Networks · Quantitative Biology 2015-06-15 Michael Assaf , Elijah Roberts , Zaida Luthey-Schulten , Nigel Goldenfeld

The sampling of Boltzmann distributions by stochastic Markov processes, can be strongly limited by the crossing time of high (free) energy barriers. As a result, the system may stay trapped in metastable states, and the relaxation time to…

Statistical Mechanics · Physics 2015-05-13 Henri Orland

We present a self-consistent field approximation to the problem of the genetic switch composed of two mutually repressing/activating genes. The protein and DNA state dynamics are treated stochastically and on equal footing. In this approach…

Molecular Networks · Quantitative Biology 2009-11-10 Aleksandra M. Walczak , Masaki Sasai , Peter G. Wolynes

Cell-to-cell variability is inherent to numerous biological processes, including cell migration. Quantifying and characterizing the variability of migrating cells is challenging, as it requires monitoring many cells for long time windows…

Biological Physics · Physics 2021-05-06 David B. Brückner , Alexandra Fink , Joachim O. Rädler , Chase P. Broedersz

We report on an astonishing switching synchronization phenomenon in one-dimensional memristive networks, which occurs when several memristive systems with different switching constants are switched from the high to low resistance state. Our…

Mesoscale and Nanoscale Physics · Physics 2016-10-31 V. A. Slipko , M. Shumovskyi , Y. V. Pershin

Many biological processes, from cell division to viral lysis, are triggered when an internal stochastic variable reaches a threshold. Here we introduce Branching under First-Passage Resetting, a general framework in which replication events…

Populations and Evolution · Quantitative Biology 2026-05-19 Aanjaneya Kumar , James Holehouse

We introduce a variant of the asymmetric random average process with continuous state variables where the maximal transport is restricted by a cutoff. For periodic boundary conditions, we show the existence of a phase transition between a…

Statistical Mechanics · Physics 2009-11-07 Frank Zielen , Andreas Schadschneider

We study a stochastic SIS (susceptible-infected-susceptible) epidemic dynamics on network, under the effect of a Markovian regime-switching. We first prove the existence of a unique global positive solution, and find a positive invariant…

Probability · Mathematics 2023-01-03 Stefania Ottaviano , Stefano Bonaccorsi

We study an excitable active rotator with slowly adapting nonlinear feedback and noise. Depending on the adaptation and the noise level, this system may display noise-induced spiking, noise-perturbed oscillations, or stochastic busting. We…

Adaptation and Self-Organizing Systems · Physics 2020-08-26 Igor Franović , Serhiy Yanchuk , Sebastian Eydam , Iva Bačić , Matthias Wolfrum

Resetting, in which a system is regularly returned to a given state after a fixed or random duration, has become a useful strategy to optimize the search performance of a system. While earlier theoretical frameworks focused on instantaneous…

Statistical Mechanics · Physics 2024-10-14 Prashant Singh

A perturbation framework is developed to analyze metastable behavior in stochastic processes with random internal and external states. The process is assumed to be under weak noise conditions, and the case where the deterministic limit is…

Analysis of PDEs · Mathematics 2013-09-23 Jay Newby , Jon Chapman

The foraging problem asks how a collective of particles with limited computational, communication and movement capabilities can autonomously compress around a food source and disperse when the food is depleted or shifted, which may occur at…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-08-24 Shunhao Oh , Dana Randall , Andréa W. Richa

Cellular transformations which involve a significant phenotypical change of the cell's state use bistable biochemical switches as underlying decision systems. In this work, we aim at linking cellular decisions taking place on a time scale…

Cell Behavior · Quantitative Biology 2010-05-11 Steffen Waldherr , Jingbo Wu , Frank Allgöwer

We study the impact of stochastic perturbations to deterministic dynamical systems using the formalism of the Ruelle response theory and explore how stochastic noise can be used to explore the properties of the underlying deterministic…

Statistical Mechanics · Physics 2015-05-27 Valerio Lucarini

This paper develops a predictive switching control algorithm for stochastic gene regulatory networks described by a Partial Integro-Differential Equation (PIDE) model, which enables direct shape control of the probability density function.…

Dynamical Systems · Mathematics 2026-05-11 Christian Fernández , Manuel Pájaro , Gábor Szederkényi , Irene Otero-Muras

To increase the training speed of distributed learning, recent years have witnessed a significant amount of interest in developing both synchronous and asynchronous distributed stochastic variance-reduced optimization methods. However, all…

Machine Learning · Computer Science 2022-08-30 Zhuqing Liu , Xin Zhang , Jia Liu

In this paper we consider the one-dimensional dynamical evolution of a particle traveling at constant speed and performing, at a given rate, random reversals of the velocity direction. The particle is subject to stochastic resetting,…

Statistical Mechanics · Physics 2021-10-25 Mattia Radice