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Accurate diagnostic coding of medical notes is crucial for enhancing patient care, medical research, and error-free billing in healthcare organizations. Manual coding is a time-consuming task for providers, and diagnostic codes often…

Machine Learning · Computer Science 2024-12-17 Prajwal Kailas , Max Homilius , Rahul C. Deo , Calum A. MacRae

An important issue impacting healthcare is a lack of available experts. Machine learning (ML) models could resolve this by aiding in diagnosing patients. However, creating datasets large enough to train these models is expensive. We…

Computation and Language · Computer Science 2024-05-14 Chancellor R. Woolsey , Prakash Bisht , Joshua Rothman , Gondy Leroy

Longitudinal clinical notes contain rich evidence of how patients evolve over time, but converting this signal into training supervision for clinical prediction remains challenging. We extend Foresight Learning to clinical prediction by…

Machine Learning · Computer Science 2026-05-14 Benjamin Turtel , Paul Wilczewski , Kris Skotheim

The recommendation of medication is a vital aspect of intelligent healthcare systems, as it involves prescribing the most suitable drugs based on a patient's specific health needs. Unfortunately, many sophisticated models currently in use…

Information Retrieval · Computer Science 2025-01-28 Qidong Liu , Xian Wu , Xiangyu Zhao , Yuanshao Zhu , Zijian Zhang , Feng Tian , Yefeng Zheng

$\textbf{Background:}$ At the onset of a pandemic, such as COVID-19, data with proper labeling/attributes corresponding to the new disease might be unavailable or sparse. Machine Learning (ML) models trained with the available data, which…

The massive scale and growth of textual biomedical data have made its indexing and classification increasingly important. However, existing research on this topic mainly utilized convolutional and recurrent neural networks, which generally…

Computation and Language · Computer Science 2022-03-08 Bruce Nguyen , Shaoxiong Ji

Sequence labeling is an important technique employed for many Natural Language Processing (NLP) tasks, such as Named Entity Recognition (NER), slot tagging for dialog systems and semantic parsing. Large-scale pre-trained language models…

Computation and Language · Computer Science 2020-12-14 Yaqing Wang , Subhabrata Mukherjee , Haoda Chu , Yuancheng Tu , Ming Wu , Jing Gao , Ahmed Hassan Awadallah

Unsupervised pretraining is an integral part of many natural language processing systems, and transfer learning with language models has achieved remarkable results in many downstream tasks. In the clinical application of medical code…

Computation and Language · Computer Science 2022-06-03 Shaoxiong Ji , Matti Hölttä , Pekka Marttinen

The practice of fine-tuning Pre-trained Language Models (PLMs) from general or domain-specific data to a specific task with limited resources, has gained popularity within the field of natural language processing (NLP). In this work, we…

Computation and Language · Computer Science 2023-10-31 Samuel Belkadi , Lifeng Han , Yuping Wu , Goran Nenadic

The introduction of Large Language Models (LLMs), and the vast volume of publicly available medical data, amplified the application of NLP to the medical domain. However, LLMs are pretrained on data that are not explicitly relevant to the…

Computation and Language · Computer Science 2023-12-12 Chris Solomou

Multimodal (MM) learning is emerging as a promising paradigm in biomedical artificial intelligence (AI) applications, integrating complementary modality, which highlight different aspects of patient health. The scarcity of large…

Artificial Intelligence · Computer Science 2025-12-01 Niccolo Marini , Zhaohui Liang , Sivaramakrishnan Rajaraman , Zhiyun Xue , Sameer Antani

Electronic Health Records (EHRs) provide crucial information for clinical decision-making. However, their high-dimensionality, heterogeneity, and sparsity make clinical prediction challenging. Large Language Models (LLMs) allowed progress…

Computation and Language · Computer Science 2026-01-28 Jesus Lovon-Melgarejo , Jose G. Moreno , Christine Damase-Michel , Lynda Tamine

This survey reviews how large language models (LLMs) are transforming synthetic training data generation in both natural language and code domains. By producing artificial but task-relevant examples, these models can significantly augment…

Computation and Language · Computer Science 2025-11-21 Mihai Nadas , Laura Diosan , Andreea Tomescu

The increasing availability of unstructured clinical narratives in electronic health records (EHRs) has created new opportunities for automated disease characterization, cohort identification, and clinical decision support. However,…

Computation and Language · Computer Science 2026-03-03 Fariba Afrin Irany , Sampson Akwafuo

Clinical natural language processing requires methods that can address domain-specific challenges, such as complex medical terminology and clinical contexts. Recently, large language models (LLMs) have shown promise in this domain. Yet,…

Computation and Language · Computer Science 2025-01-28 Ran Xu , Hejie Cui , Yue Yu , Xuan Kan , Wenqi Shi , Yuchen Zhuang , Wei Jin , Joyce Ho , Carl Yang

Large pre-trained language models (LMs) have been widely adopted in biomedical and clinical domains, introducing many powerful LMs such as bio-lm and BioELECTRA. However, the applicability of these methods to real clinical use cases is…

Computation and Language · Computer Science 2022-11-16 Samuel Cahyawijaya , Bryan Wilie , Holy Lovenia , Huan Zhong , MingQian Zhong , Yuk-Yu Nancy Ip , Pascale Fung

Data-to-text (D2T) generation in the biomedical domain is a promising - yet mostly unexplored - field of research. Here, we apply neural models for D2T generation to a real-world dataset consisting of package leaflets of European medicines.…

Machine Learning · Computer Science 2021-09-06 Ruslan Yermakov , Nicholas Drago , Angelo Ziletti

Large Language Models (LLMs) have revolutionized various sectors, including healthcare where they are employed in diverse applications. Their utility is particularly significant in the context of rare diseases, where data scarcity,…

Computation and Language · Computer Science 2024-08-20 Qiuhao Lu , Rui Li , Andrew Wen , Jinlian Wang , Liwei Wang , Hongfang Liu

We introduce NoteChat, a novel cooperative multi-agent framework leveraging Large Language Models (LLMs) to generate patient-physician dialogues. NoteChat embodies the principle that an ensemble of role-specific LLMs, through structured…

Computation and Language · Computer Science 2025-01-30 Junda Wang , Zonghai Yao , Zhichao Yang , Huixue Zhou , Rumeng Li , Xun Wang , Yucheng Xu , Hong Yu

Discovering new drug molecules is a pivotal yet challenging process due to the near-infinitely large chemical space and notorious demands on time and resources. Numerous generative models have recently been introduced to accelerate the drug…

Computational Engineering, Finance, and Science · Computer Science 2025-12-23 Shitong Luo , Wenhao Gao , Zuofan Wu , Jian Peng , Connor W. Coley , Jianzhu Ma