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Here we describe an "information based exchange" model of brain function that ascribes to neocortex, basal ganglia, and thalamus distinct network functions. The model allows us to analyze whole brain system set point measures, such as the…

Neurons and Cognition · Quantitative Biology 2015-09-17 James Kozloski

The apparent stochasticity of in-vivo neural circuits has long been hypothesized to represent a signature of ongoing stochastic inference in the brain. More recently, a theoretical framework for neural sampling has been proposed, which…

Neurons and Cognition · Quantitative Biology 2017-03-14 Mihai A. Petrovici , Ilja Bytschok , Johannes Bill , Johannes Schemmel , Karlheinz Meier

The brain is an intricately structured organ responsible for the rich emergent dynamics that support the complex cognitive functions we enjoy as humans. With around $10^{11}$ neurons and $10^{15}$ synapses, understanding how the human brain…

Neurons and Cognition · Quantitative Biology 2019-02-12 Jason Z. Kim , Danielle S. Bassett

Recent advances at the intersection of control theory, neuroscience, and machine learning have revealed novel mechanisms by which dynamical systems perform computation. These advances encompass a wide range of conceptual, mathematical, and…

Machine Learning · Computer Science 2026-04-10 Arthur N. Montanari , Francesco Bullo , Dmitry Krotov , Adilson E. Motter

Neural dynamics of energy-based models are governed by energy minimization and the patterns stored in the network are retrieved when the system reaches equilibrium. However, when the system is driven by time-varying external input, the…

Neurons and Cognition · Quantitative Biology 2020-12-25 Kevin S. Chen

Complex systems are often modeled as Boolean networks in attempts to capture their logical structure and reveal its dynamical consequences. Approximating the dynamics of continuous variables by discrete values and Boolean logic gates may,…

Molecular Networks · Quantitative Biology 2013-05-29 Johannes Norrell , Joshua E. S. Socolar

The understanding of neural activity patterns is fundamentally linked to an understanding of how the brain's network architecture shapes dynamical processes. Established approaches rely mostly on deviations of a given network from certain…

Neurons and Cognition · Quantitative Biology 2014-09-19 Marc-Thorsten Huett , Marcus Kaiser , Claus C. Hilgetag

This paper develops a mathematical framework to study signal networks, in which nodes can be active or inactive, and their activation or deactivation is driven by external signals and the states of the nodes to which they are connected via…

Probability · Mathematics 2025-10-14 Bernd Heidergott , Frank den Hollander , Ines Lindner , Azadeh Parvaneh

We investigate dynamical systems characterized by a time series of distinct semi-stable activity patterns, as they are observed in cortical neural activity patterns. We propose and discuss a general mechanism allowing for an adiabatic…

Disordered Systems and Neural Networks · Physics 2010-02-11 Claudius Gros

Complex systems, from the human brain to the global economy, are made of multiple elements that interact in such ways that the behaviour of the `whole' often seems to be more than what is readily explainable in terms of the `sum of the…

Neurons and Cognition · Quantitative Biology 2021-09-28 Pedro A. M. Mediano , Fernando E. Rosas , Andrea I Luppi , Robin L. Carhart-Harris , Daniel Bor , Anil K. Seth , Adam B. Barrett

Recent studies on transportation networks have shown that real-time route guidance can inadvertently induce congestion or oscillatory traffic patterns. Nevertheless, such technologies also offer a promising opportunity to manage traffic…

Systems and Control · Electrical Eng. & Systems 2026-01-21 Shaya Garjani , Ashish Cherukuri , Bayu Jayawardhana , Nima Monshizadeh

Recent progress in experimental techniques has enabled us to quantitatively study stochastic and flexible behavior of biological systems. For example, gene regulatory networks perform stochastic information processing and their…

Statistical Mechanics · Physics 2018-06-21 Shun Otsubo , Takahiro Sagawa

As experiments advance to record from tens of thousands of neurons, statistical physics provides a framework for understanding how collective activity emerges from networks of fine-scale correlations. While modeling these populations is…

Biological Physics · Physics 2024-12-25 David P. Carcamo , Christopher W. Lynn

Communication of signals among nodes in a complex network poses fundamental problems of efficiency and cost. Routing of messages along shortest paths requires global information about the topology, while spreading by diffusion, which…

Neurons and Cognition · Quantitative Biology 2019-06-19 Andrea Avena-Koenigsberger , Xiaoran Yan , Artemy Kolchinsky , Martijn van den Heuvel , Patric Hagmann , Olaf Sporns

Empirical complex systems must differentially respond to external perturbations and, at the same time, internally distribute information to coordinate their components. While networked backbones help with the latter, they limit the…

Physics and Society · Physics 2025-04-18 Arsham Ghavasieh , Manlio De Domenico

The nervous system encodes continuous information from the environment in the form of discrete spikes, and then decodes these to produce smooth motor actions. Understanding how spikes integrate, represent, and process information to produce…

Neural and Evolutionary Computing · Computer Science 2017-11-15 Madhavun Candadai Vasu , Eduardo Izquierdo

A core feature of complex systems is that the interactions between elements in the present causally constrain each-other as the system evolves through time. To fully model all of these interactions (between elements, as well as ensembles of…

Neurons and Cognition · Quantitative Biology 2023-04-26 Thomas F. Varley

The information processing capacity of a complex dynamical system is reflected in the partitioning of its state space into disjoint basins of attraction, with state trajectories in each basin flowing towards their corresponding attractor.…

Disordered Systems and Neural Networks · Physics 2007-05-23 Peter Krawitz , Ilya Shmulevich

Over the past two decades, an increasing array of control-theoretic methods have been used to study the brain as a complex dynamical system and better understand its structure-function relationship. This article provides an overview on one…

Neurons and Cognition · Quantitative Biology 2024-10-18 Michael McCreesh , Erfan Nozari , Jorge Cortes

Fluctuations in biochemical networks, e.g., in a living cell, have a complex origin that precludes a description of such systems in terms of bipartite or multipartite processes, as is usually done in the framework of stochastic and/or…

Statistical Mechanics · Physics 2020-01-29 R. Chétrite , M. L. Rosinberg , T. Sagawa , G. Tarjus