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Multiple Instance Learning (MIL) has been widely applied to medical imaging diagnosis, where bag labels are known and instance labels inside bags are unknown. Traditional MIL assumes that instances in each bag are independent samples from a…

Image and Video Processing · Electrical Eng. & Systems 2023-07-19 Yunan Wu , Francisco M. Castro-Macías , Pablo Morales-Álvarez , Rafael Molina , Aggelos K. Katsaggelos

We generalise the problem of reward modelling (RM) for reinforcement learning (RL) to handle non-Markovian rewards. Existing work assumes that human evaluators observe each step in a trajectory independently when providing feedback on agent…

Machine Learning · Computer Science 2022-10-11 Joseph Early , Tom Bewley , Christine Evers , Sarvapali Ramchurn

In-context learning (ICL) has emerged as a powerful capability for large language models (LLMs) to adapt to downstream tasks by leveraging a few (demonstration) examples. Despite its effectiveness, the mechanism behind ICL remains…

Machine Learning · Computer Science 2025-06-03 Pengfei He , Yingqian Cui , Han Xu , Hui Liu , Makoto Yamada , Jiliang Tang , Yue Xing

Introducing interpretability and reasoning into Multiple Instance Learning (MIL) methods for Whole Slide Image (WSI) analysis is challenging, given the complexity of gigapixel slides. Traditionally, MIL interpretability is limited to…

Computer Vision and Pattern Recognition · Computer Science 2024-05-21 Saarthak Kapse , Pushpak Pati , Srijan Das , Jingwei Zhang , Chao Chen , Maria Vakalopoulou , Joel Saltz , Dimitris Samaras , Rajarsi R. Gupta , Prateek Prasanna

Predicting breast cancer recurrence risk is a critical clinical challenge. This study investigates the potential of computational pathology to stratify patients using deep learning on routine Hematoxylin and Eosin (H&E) stained whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2025-12-23 Jinqiu Chen , Huyan Xu

In a standard multi-output classification scenario, both features and labels of training data are partially observed. This challenging issue is widely witnessed due to sensor or database failures, crowd-sourcing and noisy communication…

Machine Learning · Computer Science 2019-12-20 Giancarlo Fissore , Aurélien Decelle , Cyril Furtlehner , Yufei Han

Recently, pathological diagnosis has achieved superior performance by combining deep learning models with the multiple instance learning (MIL) framework using whole slide images (WSIs). However, the giga-pixeled nature of WSIs poses a great…

Computer Vision and Pattern Recognition · Computer Science 2024-10-31 Zijie Fang , Yifeng Wang , Ye Zhang , Zhi Wang , Jian Zhang , Xiangyang Ji , Yongbing Zhang

Applying Artificial Intelligence (AI) and Machine Learning (ML) in critical contexts, such as medicine, requires the implementation of safety measures to reduce risks of harm in case of prediction errors. Spotting ML failures is of…

Multiple Instance Learning (MIL) methods have succeeded remarkably in histopathology whole slide image (WSI) analysis. However, most MIL models only offer attention-based explanations that do not faithfully capture the model's decision…

Computer Vision and Pattern Recognition · Computer Science 2025-07-17 Susu Sun , Dominique van Midden , Geert Litjens , Christian F. Baumgartner

Class incremental learning (CIL) algorithms aim to continually learn new object classes from incrementally arriving data while not forgetting past learned classes. The common evaluation protocol for CIL algorithms is to measure the average…

Machine Learning · Computer Science 2024-06-26 Sungmin Cha , Jihwan Kwak , Dongsub Shim , Hyunwoo Kim , Moontae Lee , Honglak Lee , Taesup Moon

Multiple Instance Learning (MIL) models have proven effective for cancer prognosis from Whole Slide Images. However, the original MIL formulation incorrectly assumes the patches of the same image to be independent, leading to a loss of…

Computer Vision and Pattern Recognition · Computer Science 2024-08-13 Thiziri Nait Saada , Valentina Di Proietto , Benoit Schmauch , Katharina Von Loga , Lucas Fidon

An important task at the onset of a laparoscopic cholecystectomy (LC) operation is the inspection of gallbladder (GB) to evaluate the thickness of its wall, presence of inflammation and extent of fat. Difficulty in visualization of the GB…

Computer Vision and Pattern Recognition · Computer Science 2021-07-29 C. Loukas , A. Gazis , D. Schizas

Multiple instance learning (MIL) has emerged as the dominant paradigm for whole slide image (WSI) analysis in computational pathology, achieving strong diagnostic performance through patch-level feature aggregation. However, existing MIL…

Computer Vision and Pattern Recognition · Computer Science 2025-11-17 Yiran Song , Yikai Zhang , Shuang Zhou , Guojun Xiong , Xiaofeng Yang , Nian Wang , Fenglong Ma , Rui Zhang , Mingquan Lin

Partial multi-label learning (PML) models the scenario where each training instance is annotated with a set of candidate labels, and only some of the labels are relevant. The PML problem is practical in real-world scenarios, as it is…

Machine Learning · Computer Science 2020-03-18 Tingting Yu , Guoxian Yu , Jun Wang , Maozu Guo

We consider a weakly supervised learning scenario where the supervision signal is generated by a transition function $\sigma$ of labels associated with multiple input instances. We formulate this problem as \emph{multi-instance Partial…

Machine Learning · Computer Science 2024-07-16 Kaifu Wang , Efthymia Tsamoura , Dan Roth

Advanced classification algorithms are being increasingly used in safety-critical applications like health-care, engineering, etc. In such applications, miss-classifications made by ML algorithms can result in substantial financial or…

Machine Learning · Computer Science 2024-12-06 Disha Ghandwani , Neeraj Sarna , Yuanyuan Li , Yang Lin

Supervised contrastive learning has achieved remarkable success by leveraging label information; however, determining positive samples in multi-label scenarios remains a critical challenge. In multi-label supervised contrastive learning…

Machine Learning · Computer Science 2025-09-30 Guangming Huang , Yunfei Long , Cunjin Luo

Histopathology image analysis can be considered as a Multiple instance learning (MIL) problem, where the whole slide histopathology image (WSI) is regarded as a bag of instances (i.e, patches) and the task is to predict a single class label…

Computer Vision and Pattern Recognition · Computer Science 2019-06-28 Meng Li , Lin Wu , Arnold Wiliem , Kun Zhao , Teng Zhang , Brian C. Lovell

Label Proportion Learning (LLP) addresses the classification problem where multiple instances are grouped into bags and each bag contains information about the proportion of each class. However, in practical applications, obtaining precise…

Machine Learning · Computer Science 2025-07-15 Jiahe Qin , Junpeng Li , Changchun Hua , Yana Yang

Learning accurate object detectors often requires large-scale training data with precise object bounding boxes. However, labeling such data is expensive and time-consuming. As the crowd-sourcing labeling process and the ambiguities of the…

Computer Vision and Pattern Recognition · Computer Science 2022-07-21 Chengxin Liu , Kewei Wang , Hao Lu , Zhiguo Cao , Ziming Zhang
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