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Conformation generation, also known as molecular unfolding (MU), is a crucial step in structure-based drug design, remaining a challenging combinatorial optimization problem. Quantum annealing (QA) has shown great potential for solving…

The RNA inverse folding problem aims to identify nucleotide sequences that preferentially adopt a given target secondary structure. While various heuristic and machine learning-based approaches have been proposed, many require a large…

Machine Learning · Computer Science 2026-02-19 Shuta Kikuchi , Shu Tanaka

Field-Programmable Gate Arrays (FPGAs) have asserted themselves as vital assets in contemporary computing by offering adaptable, reconfigurable hardware platforms. FPGA-based accelerators incubate opportunities for breakthroughs in areas,…

With the current progress of quantum computing, quantum annealing is being introduced as a powerful method to solve hard computational problems. In this paper, we study the potential capability of quantum annealing in solving the phase…

Image and Video Processing · Electrical Eng. & Systems 2023-09-20 Mohammad Kashfi Haghighi , Nikitas Dimopoulos

Recent advances in quantum technology have led to the development and manufacturing of experimental programmable quantum annealers that promise to solve certain combinatorial optimization problems of practical relevance faster than their…

Quantum Physics · Physics 2016-05-31 Itay Hen , Federico M. Spedalieri

Quantum annealers are specialized quantum computers for solving combinatorial optimization problems using special characteristics of quantum computing (QC), such as superposition, entanglement, and quantum tunneling. Theoretically, quantum…

Software Engineering · Computer Science 2024-07-29 Xinyi Wang , Asmar Muqeet , Tao Yue , Shaukat Ali , Paolo Arcaini

Quantum computing has emerged as a powerful tool to efficiently solve computational challenges, particularly in simulation and optimisation. However, hardware limitations prevent quantum computers from achieving the full theoretical…

Emerging Technologies · Computer Science 2025-05-01 Hugo Araujo , Xinyi Wang , Mohammad Mousavi , Shaukat Ali

Quantum annealing is a promising paradigm for building practical quantum computers. Compared to other approaches, quantum annealing technology has been scaled up to a larger number of qubits. On the other hand, deep learning has been…

Quantum Physics · Physics 2021-07-07 Michele Sasdelli , Tat-Jun Chin

We propose a new kernel that quantifies success for the task of computing a core-periphery partition for an undirected network. Finding the associated optimal partitioning may be expressed in the form of a quadratic unconstrained binary…

Social and Information Networks · Computer Science 2022-01-06 Catherine F. Higham , Desmond J. Higham , Francesco Tudisco

In the near-term, hybrid quantum-classical algorithms hold great potential for outperforming classical approaches. Understanding how these two computing paradigms work in tandem is critical for identifying areas where such hybrid algorithms…

Diagnosing the minimal set of faults capable of explaining a set of given observations, e.g., from sensor readouts, is a hard combinatorial optimization problem usually tackled with artificial intelligence techniques. We present the mapping…

Quantum annealers can be used to solve many (possibly NP-hard) combinatorial optimization problems, by formulating them as quadratic unconstrained binary optimization (QUBO) problems or, equivalently, using the Ising formulation. In this…

Quantum Physics · Physics 2024-06-13 Alessandro Gherardi , Alberto Leporati

Minor embedding is essential for mapping largescale combinatorial problems onto quantum annealers, particularly in quantum machine learning and optimization. This work presents an optimized, universal minor-embedding framework that…

Quantum Physics · Physics 2025-05-01 Salvatore Sinno , Thomas Groß , Nicholas Chancellor , Bhavika Bhalgamiya , Arati Sahoo

We implement a quantum protocol for prime number identification based on entanglement dynamics, using IBM quantum processors. The method links the primality of an integer to specific Fourier components extracted from the time evolution of…

Quantum Physics · Physics 2026-05-29 Victor F. dos Santos , Victor P. Brasil , Pedro A. S. Contri , Jonas Maziero

Quantum annealing allows for quantum fluctuations to be used used to assist in finding the solution to some of the worlds most challenging computational problems. Recently, this field has attracted much interest because of the construction…

Quantum Physics · Physics 2022-07-26 Nicholas Chancellor

Factorization Machine (FM) is the most commonly used model to build a recommendation system since it can incorporate side information to improve performance. However, producing item suggestions for a given user with a trained FM is…

Quantum Physics · Physics 2023-11-09 Chen-Yu Liu , Hsin-Yu Wang , Pei-Yen Liao , Ching-Jui Lai , Min-Hsiu Hsieh

Quantum annealing (QA) has the potential to significantly improve solution quality and reduce time complexity in solving combinatorial optimization problems compared to classical optimization methods. However, due to the limited number of…

Quantum Physics · Physics 2025-04-09 Seongmin Kim , Sang-Woo Ahn , In-Saeng Suh , Alexander W. Dowling , Eungkyu Lee , Tengfei Luo

Over the past decade, the usefulness of quantum annealing hardware for combinatorial optimization has been the subject of much debate. Thus far, experimental benchmarking studies have indicated that quantum annealing hardware does not…

Optimization and Control · Mathematics 2022-10-11 Byron Tasseff , Tameem Albash , Zachary Morrell , Marc Vuffray , Andrey Y. Lokhov , Sidhant Misra , Carleton Coffrin

The solution of physical problems discretized using the finite element methods using quantum computers remains relatively unexplored. Here, we present a unified formulation (FEqa) to solve such problems using quantum annealers. FEqa is a…

Quantum Physics · Physics 2022-05-25 Osama Muhammad Raisuddin , Suvranu De

Quantum annealers (QAs) are specialized quantum computers that minimize objective functions over discrete variables by physically exploiting quantum effects. Current QA platforms allow for the optimization of quadratic objectives defined…

Emerging Technologies · Computer Science 2018-11-07 Zhengbing Bian , Fabian Chudak , William Macready , Aidan Roy , Roberto Sebastiani , Stefano Varotti