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Tokenization is a crucial step in processing protein sequences for machine learning models, as proteins are complex sequences of amino acids that require meaningful segmentation to capture their functional and structural properties.…

Computation and Language · Computer Science 2024-11-27 Burak Suyunu , Enes Taylan , Arzucan Özgür

Less than 1% of protein sequences are structurally and functionally annotated. Natural Language Processing (NLP) community has recently embraced self-supervised learning as a powerful approach to learn representations from unlabeled text,…

Biomolecules · Quantitative Biology 2020-12-08 Modestas Filipavicius , Matteo Manica , Joris Cadow , Maria Rodriguez Martinez

We explore optimally training protein language models, an area of significant interest in biological research where guidance on best practices is limited. Most models are trained with extensive compute resources until performance gains…

Machine Learning · Computer Science 2024-11-05 Xingyi Cheng , Bo Chen , Pan Li , Jing Gong , Jie Tang , Le Song

Protein is linked to almost every life process. Therefore, analyzing the biological structure and property of protein sequences is critical to the exploration of life, as well as disease detection and drug discovery. Traditional protein…

Machine Learning · Computer Science 2021-12-08 Yijia Xiao , Jiezhong Qiu , Ziang Li , Chang-Yu Hsieh , Jie Tang

Attention-based models trained on protein sequences have demonstrated incredible success at classification and generation tasks relevant for artificial intelligence-driven protein design. However, we lack a sufficient understanding of how…

Machine Learning · Computer Science 2022-06-29 Erik Nijkamp , Jeffrey Ruffolo , Eli N. Weinstein , Nikhil Naik , Ali Madani

While protein language models (pLMs) have transformed biological research, the scaling laws governing their improvement remain underexplored. By adapting methodologies from NLP scaling laws, we investigated the optimal ratio between model…

Biomolecules · Quantitative Biology 2024-06-27 Yaiza Serrano , Álvaro Ciudad , Alexis Molina

This paper presents a comprehensive examination of the impact of tokenization strategies and vocabulary sizes on the performance of Arabic language models in downstream natural language processing tasks. Our investigation focused on the…

Computation and Language · Computer Science 2024-09-23 Mohamed Taher Alrefaie , Nour Eldin Morsy , Nada Samir

Modern Protein Language Models (PLMs) apply transformer-based model architectures from natural language processing to biological sequences, predicting a variety of protein functions and properties. However, protein language has key…

Machine Learning · Computer Science 2026-02-25 Anna Hart , Chi Han , Jeonghwan Kim , Huimin Zhao , Heng Ji

Contextual embedding-based language models trained on large data sets, such as BERT and RoBERTa, provide strong performance across a wide range of tasks and are ubiquitous in modern NLP. It has been observed that fine-tuning these models on…

Computation and Language · Computer Science 2021-09-16 Vin Sachidananda , Jason S. Kessler , Yi-an Lai

Instruction-tuning language models has become a crucial step in aligning them for general use. Typically, this process involves extensive training on large datasets, incurring high training costs. In this paper, we introduce a novel…

Computation and Language · Computer Science 2024-02-19 Dheeraj Mekala , Alex Nguyen , Jingbo Shang

Continued pre-training of small language models offers a promising path for domain adaptation with limited computational resources. I've investigated this approach within educational domains, evaluating it as a resource-efficient…

Computation and Language · Computer Science 2025-04-15 Salman Faroz

One of the challenges with finetuning pretrained language models (PLMs) is that their tokenizer is optimized for the language(s) it was pretrained on, but brittle when it comes to previously unseen variations in the data. This can for…

Computation and Language · Computer Science 2023-04-21 Verena Blaschke , Hinrich Schütze , Barbara Plank

Large language models have recently achieved state of the art performance across a wide variety of natural language tasks. Meanwhile, the size of these models and their latency have significantly increased, which makes their usage costly,…

Computation and Language · Computer Science 2021-03-30 Ziheng Wang , Jeremy Wohlwend , Tao Lei

Subword tokenization methods, such as Byte-Pair Encoding (BPE), significantly impact the performance and efficiency of large language models (LLMs). The standard approach involves training a general-purpose tokenizer that uniformly…

Computation and Language · Computer Science 2026-01-30 Vijini Liyanage , François Yvon

Large language models are versatile tools but are not suitable for small inference budgets. Small models have more efficient inference, but their lower capacity means that their performance can be good only if one limits their scope to a…

Machine Learning · Computer Science 2024-11-01 David Grangier , Angelos Katharopoulos , Pierre Ablin , Awni Hannun

The zero-shot cross-lingual ability of models pretrained on multilingual and even monolingual corpora has spurred many hypotheses to explain this intriguing empirical result. However, due to the costs of pretraining, most research uses…

Computation and Language · Computer Science 2022-09-28 Hugo Abonizio , Leandro Rodrigues de Souza , Roberto Lotufo , Rodrigo Nogueira

We introduce a pioneering methodology for boosting large language models in the domain of protein representation learning. Our primary contribution lies in the refinement process for correlating the over-reliance on co-evolution knowledge,…

Artificial Intelligence · Computer Science 2024-12-05 Yaoyao Xu , Xinjian Zhao , Xiaozhuang Song , Benyou Wang , Tianshu Yu

Tokenization, a crucial initial step in natural language processing, is governed by several key parameters, such as the tokenization algorithm, vocabulary size, pre-tokenization strategy, inference strategy, and training data corpus. This…

Computation and Language · Computer Science 2025-06-17 Varshini Reddy , Craig W. Schmidt , Yuval Pinter , Chris Tanner

The effectiveness of Neural Machine Translation (NMT) models largely depends on the vocabulary used at training; small vocabularies can lead to out-of-vocabulary problems -- large ones, to memory issues. Subword (SW) tokenization has been…

Computation and Language · Computer Science 2023-03-02 J. Pourmostafa Roshan Sharami , D. Shterionov , P. Spronck

The recent success of Large Language Models (LLMs) has been predominantly driven by curating the training dataset composition, scaling of model architectures and dataset sizes and advancements in pretraining objectives, leaving tokenizer…

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