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Application of interpretable machine learning techniques on medical datasets facilitate early and fast diagnoses, along with getting deeper insight into the data. Furthermore, the transparency of these models increase trust among…

Machine Learning · Computer Science 2025-06-05 Sreejita Ghosh , Elizabeth S. Baranowski , Michael Biehl , Wiebke Arlt , Peter Tino , Kerstin Bunte

Prototypical part networks offer interpretable alternatives to black-box deep learning models by learning visual prototypes for classification. This work provides a comprehensive analysis of prototype formulations, comparing point-based and…

Machine Learning · Computer Science 2026-01-08 Maximilian Xiling Li , Korbinian Franz Rudolf , Paul Mattes , Nils Blank , Rudolf Lioutikov

Many interpretable AI approaches have been proposed to provide plausible explanations for a model's decision-making. However, configuring an explainable model that effectively communicates among computational modules has received less…

Machine Learning · Computer Science 2023-11-09 Jinyung Hong , Keun Hee Park , Theodore P. Pavlic

Machine learning models that utilize patient data across time (rather than just the most recent measurements) have increased performance for many risk stratification tasks in the intensive care unit. However, many of these models and their…

Machine Learning · Computer Science 2021-09-24 Nari Johnson , Sonali Parbhoo , Andrew Slavin Ross , Finale Doshi-Velez

Recent applications of deep convolutional neural networks in medical imaging raise concerns about their interpretability. While most explainable deep learning applications use post hoc methods (such as GradCAM) to generate feature…

Computer Vision and Pattern Recognition · Computer Science 2023-04-17 Yuanyuan Wei , Roger Tam , Xiaoying Tang

Exponential growth in Electronic Healthcare Records (EHR) has resulted in new opportunities and urgent needs for discovery of meaningful data-driven representations and patterns of diseases in Computational Phenotyping research. Deep…

Machine Learning · Statistics 2015-12-14 Zhengping Che , Sanjay Purushotham , Robinder Khemani , Yan Liu

Large Language Models (LLMs) have significantly advanced the field of Natural Language Processing (NLP), but their lack of interpretability has been a major concern. Current methods for interpreting LLMs are post hoc, applied after…

Computation and Language · Computer Science 2023-11-14 Sean Xie , Soroush Vosoughi , Saeed Hassanpour

Prototype-based methods are of the particular interest for domain specialists and practitioners as they summarize a dataset by a small set of representatives. Therefore, in a classification setting, interpretability of the prototypes is as…

Machine Learning · Computer Science 2019-11-12 Babak Hosseini , Barbara Hammer

Interpretable predictions, where it is clear why a machine learning model has made a particular decision, can compromise privacy by revealing the characteristics of individual data points. This raises the central question addressed in this…

Machine Learning · Computer Science 2020-04-07 Frederik Harder , Matthias Bauer , Mijung Park

In safety-critical applications, practitioners are reluctant to trust neural networks when no interpretable explanations are available. Many attempts to provide such explanations revolve around pixel-based attributions or use previously…

Machine Learning · Computer Science 2022-07-25 Armeen Taeb , Nicolo Ruggeri , Carina Schnuck , Fanny Yang

To improve the performance of Intensive Care Units (ICUs), the field of bio-statistics has developed scores which try to predict the likelihood of negative outcomes. These help evaluate the effectiveness of treatments and clinical practice,…

Machine Learning · Computer Science 2019-08-23 William Caicedo-Torres , Jairo Gutierrez

In this study, we present a novel clinical decision support system and discuss its interpretability-related properties. It combines a decision set of rules with a machine learning scheme to offer global and local interpretability. More…

Methodology · Statistics 2021-07-16 Francisco Valente , Simão Paredes , Jorge Henriques

Lung cancer has the highest mortality rate of deadly cancers in the world. Early detection is essential to treatment of lung cancer. However, detection and accurate diagnosis of pulmonary nodules depend heavily on the experiences of…

Image and Video Processing · Electrical Eng. & Systems 2022-04-12 Chenglong Wang , Yun Liu , Fen Wang , Chengxiu Zhang , Yida Wang , Mei Yuan , Guang Yang

This paper explores interpretability techniques for two of the most successful learning algorithms in medical decision-making literature: deep neural networks and random forests. We applied these algorithms in a real-world medical dataset…

Machine Learning · Computer Science 2020-02-24 Catarina Moreira , Renuka Sindhgatta , Chun Ouyang , Peter Bruza , Andreas Wichert

We present ProtoConcepts, a method for interpretable image classification combining deep learning and case-based reasoning using prototypical parts. Existing work in prototype-based image classification uses a ``this looks like that''…

Computer Vision and Pattern Recognition · Computer Science 2023-10-31 Chiyu Ma , Brandon Zhao , Chaofan Chen , Cynthia Rudin

The visual representation of a pre-trained model prioritizes the classifiability on downstream tasks, while the widespread applications for pre-trained visual models have posed new requirements for representation interpretability. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-29 Shufan Shen , Zhaobo Qi , Junshu Sun , Qingming Huang , Qi Tian , Shuhui Wang

Recent deep learning methods for fMRI-based diagnosis have achieved promising accuracy by modeling functional connectivity networks. However, standard approaches often struggle with noisy interactions, and conventional post-hoc attribution…

Machine Learning · Computer Science 2026-02-25 Kunyu Zhang , Yanwu Yang , Jing Zhang , Xiangjie Shi , Shujian Yu

Deep learning frameworks have become increasingly popular in brain computer interface (BCI) study thanks to their outstanding performance. However, in terms of the classification model alone, they are treated as black box as they do not…

Neural and Evolutionary Computing · Computer Science 2021-12-15 Ji-Seon Bang , Seong-Whan Lee

Medical Image Segmentation (MIS) plays a crucial role in medical therapy planning and robot navigation. Prototype learning methods in MIS focus on generating segmentation masks through pixel-to-prototype comparison. However, current…

Methodology · Statistics 2025-07-11 Guoyan Liang , Qin Zhou , Jingyuan Chen , Zhe Wang , Chang Yao

Accurate and interpretable diagnostic models are crucial in the safety-critical field of medicine. We investigate the interpretability of our proposed biomarker-based lung ultrasound diagnostic pipeline to enhance clinicians' diagnostic…

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