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Deep learning has made significant progress in the past decade, and demonstrates potential to solve problems with extensive social impact. In high-stakes decision making areas such as law, experts often require interpretability for…

Computation and Language · Computer Science 2023-05-29 Chu Fei Luo , Rohan Bhambhoria , Samuel Dahan , Xiaodan Zhu

Interpretability in machine learning models is important in high-stakes decisions, such as whether to order a biopsy based on a mammographic exam. Mammography poses important challenges that are not present in other computer vision tasks:…

Machine Learning · Computer Science 2021-03-24 Alina Jade Barnett , Fides Regina Schwartz , Chaofan Tao , Chaofan Chen , Yinhao Ren , Joseph Y. Lo , Cynthia Rudin

Intensive Care Unit (ICU) mortality prediction, which estimates a patient's mortality status at discharge using EHRs collected early in an ICU admission, is vital in critical care. For this task, predictive accuracy alone is insufficient;…

Machine Learning · Computer Science 2025-10-15 Qingwen Li , Xiaohang Zhao , Xiao Han , Hailiang Huang , Lanjuan Liu

Many text classification applications require models with satisfying performance as well as good interpretability. Traditional machine learning methods are easy to interpret but have low accuracies. The development of deep learning models…

Computation and Language · Computer Science 2020-06-02 Zhengyang Wang , Xia Hu , Shuiwang Ji

While deep learning methods are increasingly being applied to tasks such as computer-aided diagnosis, these models are difficult to interpret, do not incorporate prior domain knowledge, and are often considered as a "black-box." The lack of…

Computer Vision and Pattern Recognition · Computer Science 2018-06-05 Shiwen Shen , Simon X. Han , Denise R. Aberle , Alex A. T. Bui , Willliam Hsu

We present a novel methodology for integrating high resolution longitudinal data with the dynamic prediction capabilities of survival models. The aim is two-fold: to improve the predictive power while maintaining interpretability of the…

Applications · Statistics 2024-03-07 Giacomo Lancia , Meri Varkila , Olaf Cremer , Cristian Spitoni

Training Artificial Intelligence (AI) models on 3D images presents unique challenges compared to the 2D case: Firstly, the demand for computational resources is significantly higher, and secondly, the availability of large datasets for…

There is a need of ensuring machine learning models that are interpretable. Higher interpretability of the model means easier comprehension and explanation of future predictions for end-users. Further, interpretable machine learning models…

Machine Learning · Computer Science 2020-08-17 Gregor Stiglic , Primoz Kocbek , Nino Fijacko , Marinka Zitnik , Katrien Verbert , Leona Cilar

Cell counting in biomedical imaging is pivotal for various clinical applications, yet the interpretability of deep learning models in this domain remains a significant challenge. We propose a novel prototype-based method for interpretable…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Abdurahman Ali Mohammed , Wallapak Tavanapong , Catherine Fonder , Donald S. Sakaguchi

In recent years, artificial intelligence (AI) systems have come to the forefront. These systems, mostly based on Deep learning (DL), achieve excellent results in areas such as image processing, natural language processing, or speech…

Computer Vision and Pattern Recognition · Computer Science 2023-04-18 Frantisek Sefcik , Wanda Benesova

Deep learning models have achieved high performance in medical applications, however, their adoption in clinical practice is hindered due to their black-box nature. Self-explainable models, like prototype-based models, can be especially…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Shreyasi Pathak , Jörg Schlötterer , Jeroen Veltman , Jeroen Geerdink , Maurice van Keulen , Christin Seifert

Explaining Deep Learning models is becoming increasingly important in the face of daily emerging multimodal models, particularly in safety-critical domains like medical imaging. However, the lack of detailed investigations into the…

Computer Vision and Pattern Recognition · Computer Science 2024-03-29 Anees Ur Rehman Hashmi , Dwarikanath Mahapatra , Mohammad Yaqub

Prototype-based neural networks offer interpretable predictions by comparing inputs to learned, representative signal patterns anchored in training data. While such models have shown promise in the classification of physiological data, it…

Machine Learning · Computer Science 2026-05-28 Sahil Sethi , David Chen , Michael C. Burkhart , Nipun Bhandari , Bashar Ramadan , Brett Beaulieu-Jones

Machine learning models that first learn a representation of a domain in terms of human-understandable concepts, then use it to make predictions, have been proposed to facilitate interpretation and interaction with models trained on…

Machine Learning · Computer Science 2020-12-08 Isaac Lage , Finale Doshi-Velez

Despite recent advances in machine learning and explainable AI, a gap remains in personalized preventive healthcare: predictions, interventions, and recommendations should be both understandable and verifiable for all stakeholders in the…

Interpretability is a pressing issue for machine learning. Common approaches to interpretable machine learning constrain interactions between features of the input, rendering the effects of those features on a model's output comprehensible…

Machine Learning · Computer Science 2023-05-11 Kieran A. Murphy , Dani S. Bassett

Diagnosing rare diseases presents a common challenge in clinical practice, necessitating the expertise of specialists for accurate identification. The advent of machine learning offers a promising solution, while the development of such…

Machine Learning · Computer Science 2024-03-12 Yifan Wu , Yang Liu , Yue Yang , Michael S. Yao , Wenli Yang , Xuehui Shi , Lihong Yang , Dongjun Li , Yueming Liu , James C. Gee , Xuan Yang , Wenbin Wei , Shi Gu

The lack of interpretability in the field of medical image analysis has significant ethical and legal implications. Existing interpretable methods in this domain encounter several challenges, including dependency on specific models,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Lijie Hu , Songning Lai , Wenshuo Chen , Hongru Xiao , Hongbin Lin , Lu Yu , Jingfeng Zhang , Di Wang

Automatic pulmonary nodules classification is significant for early diagnosis of lung cancers. Recently, deep learning techniques have enabled remarkable progress in this field. However, these deep models are typically of high computational…

Image and Video Processing · Electrical Eng. & Systems 2021-01-20 Hanliang Jiang , Fuhao Shen , Fei Gao , Weidong Han

The use of convolutional neural networks (CNNs) for classification tasks has become dominant in various medical imaging applications. At the same time, recent advances in interpretable machine learning techniques have shown great potential…

Image and Video Processing · Electrical Eng. & Systems 2019-10-02 Irina Grigorescu , Lucilio Cordero-Grande , A David Edwards , Jo Hajnal , Marc Modat , Maria Deprez