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A practical large language model (LLM) service may involve a long system prompt, which specifies the instructions, examples, and knowledge documents of the task and is reused across requests. However, the long system prompt causes…

Computation and Language · Computer Science 2024-05-31 Lei Zhu , Xinjiang Wang , Wayne Zhang , Rynson W. H. Lau

This work studies the robust evaluation of iterative stochastic purification defenses under white-box adversarial attacks. Our key technical insight is that gradient checkpointing makes exact end-to-end gradient computation through long…

Machine Learning · Computer Science 2026-05-08 Yuan Du , Mitchel Hill , HanQin Cai

Large language models can now process increasingly long inputs, yet their ability to effectively use information spread across long contexts remains limited. We trace this gap to how attention budget is spent during supervised fine-tuning…

Computation and Language · Computer Science 2026-05-12 Zehua Pei , Hui-Ling Zhen , Xianzhi Yu , Sinno Jialin Pan , Mingxuan Yuan , Bei Yu

Fine-tuning the pre-trained model with active learning holds promise for reducing annotation costs. However, this combination introduces significant computational costs, particularly with the growing scale of pre-trained models. Recent…

Machine Learning · Computer Science 2024-11-19 Ziting Wen , Oscar Pizarro , Stefan Williams

The variance in class-wise sample sizes within long-tailed scenarios often results in degraded performance in less frequent classes. Fortunately, foundation models, pre-trained on vast open-world datasets, demonstrate strong potential for…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Yufei Peng , Yonggang Zhang , Yiu-ming Cheung

Designing deep networks that meet strict latency and accuracy constraints on edge accelerators increasingly relies on hardware-aware optimization, including neural architecture search (NAS) guided by device-level metrics. Yet most…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Parampuneet Kaur Thind , Vaibhav Katturu , Giacomo Zema , Roberto Del Prete

Many advanced Large Language Model (LLM) applications require long-context processing, but the self-attention module becomes a bottleneck during the prefilling stage of inference due to its quadratic time complexity with respect to sequence…

Machine Learning · Computer Science 2025-06-02 Xiaodong Ji , Hailin Zhang , Fangcheng Fu , Bin Cui

In the last decade a number of algorithms and associated software have been developed to align next generation sequencing (NGS) reads with relevant reference genomes. The accuracy of these programs may vary significantly, especially when…

We present the Scalable Nucleotide Alignment Program (SNAP), a new short and long read aligner that is both more accurate (i.e., aligns more reads with fewer errors) and 10-100x faster than state-of-the-art tools such as BWA. Unlike recent…

Data Structures and Algorithms · Computer Science 2011-11-24 Matei Zaharia , William J. Bolosky , Kristal Curtis , Armando Fox , David Patterson , Scott Shenker , Ion Stoica , Richard M. Karp , Taylor Sittler

Rapid development of modern sequencing platforms enabled an unprecedented growth of protein families databases. The abundance of sets composed of hundreds of thousands sequences is a great challenge for multiple sequence alignment…

Genomics · Quantitative Biology 2017-03-03 Sebastin Deorowicz , Agnieszka Debudaj-Grabysz , Adam Gudys

Imbalanced classification datasets pose significant challenges in machine learning, often leading to biased models that perform poorly on underrepresented classes. With the rise of foundation models, recent research has focused on the full,…

Machine Learning · Computer Science 2025-09-22 Nakul Sharma

Spiking neural networks (SNNs) have shown a potential for having low energy with unsupervised learning capabilities due to their biologically-inspired computation. However, they may suffer from accuracy degradation if their processing is…

Hardware Architecture · Computer Science 2023-03-06 Rachmad Vidya Wicaksana Putra , Muhammad Abdullah Hanif , Muhammad Shafique

Discovering patterns in networks of protein-protein interactions (PPIs) is a central problem in systems biology. Alignments between these networks aid functional understanding as they uncover important information, such as evolutionary…

Molecular Networks · Quantitative Biology 2014-11-04 Vladimir Gligorijević , Noël Malod-Dognin , Nataša Pržulj

The computational and memory challenges of large language models (LLMs) have sparked several optimization approaches towards their efficient implementation. While prior LLM-targeted quantization, and prior works on sparse acceleration have…

Hardware Architecture · Computer Science 2025-03-18 Abhishek Moitra , Arkapravo Ghosh , Shrey Agarwal , Aporva Amarnath , Karthik Swaminathan , Priyadarshini Panda

Motivation: Seed filtering is critical in DNA read mapping, a process where billions of DNA fragments (reads) sampled from a donor are mapped onto a reference genome to identify genomic variants of the donor. Read mappers 1) quickly…

Data-driven methods are emerging as efficient alternatives to traditional numerical forecasting, offering fast inference and lower computational cost. Yet, for complex systems, long-term accuracy often deteriorates due to error…

Machine Learning · Computer Science 2025-09-03 Hao Zhou , Sibo Cheng

Sequential learning in deep models often suffers from challenges such as catastrophic forgetting and loss of plasticity, largely due to the permutation dependence of gradient-based algorithms, where the order of training data impacts the…

Machine Learning · Computer Science 2024-10-31 Akhilan Boopathy , Aneesh Muppidi , Peggy Yang , Abhiram Iyer , William Yue , Ila Fiete

Instruction tuning is critical to improve LLMs but usually suffers from low-quality and redundant data. Data filtering for instruction tuning has proved important in improving both the efficiency and performance of the tuning process. But…

Computation and Language · Computer Science 2024-06-11 Ming Li , Yong Zhang , Shwai He , Zhitao Li , Hongyu Zhao , Jianzong Wang , Ning Cheng , Tianyi Zhou

There is a growing body of research indicating the potential of machine learning to tackle complex software testing challenges. One such challenge pertains to continuous integration testing, which is highly time-constrained, and generates a…

Software Engineering · Computer Science 2022-04-26 Dusica Marijan

This paper introduces LMFAO (Layered Multiple Functional Aggregate Optimization), an in-memory optimization and execution engine for batches of aggregates over the input database. The primary motivation for this work stems from the…

Databases · Computer Science 2019-06-21 Maximilian Schleich , Dan Olteanu , Mahmoud Abo Khamis , Hung Q. Ngo , XuanLong Nguyen