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Motivation: Despite significant advances in Third-Generation Sequencing (TGS) technologies, Next-Generation Sequencing (NGS) technologies remain dominant in the current sequencing market. This is due to the lower error rates and richer…

Information Theory · Computer Science 2023-04-04 Jia Wang , Yi Niu , Tianyi Xu , Mingming Ma , Dahua Gao , Guangming Shi

Recent efforts in fine-tuning language models often rely on automatic data selection, commonly using Nearest Neighbors retrieval from large datasets. However, we theoretically show that this approach tends to select redundant data, limiting…

Machine Learning · Computer Science 2025-02-11 Jonas Hübotter , Sascha Bongni , Ido Hakimi , Andreas Krause

Code localization constitutes a key bottleneck in automated software development pipelines. While concurrent tool execution can enhance discovery speed, current agents demonstrate a 34.9\% redundant invocation rate, which negates…

Artificial Intelligence · Computer Science 2026-01-28 Ke Xu , Siyang Xiao , Ming Liang , Yichen Yu , Zhixiang Wang , Jingxuan Xu , Dajun Chen , Wei Jiang , Yong Li

Dynamic random access memory failures are a threat to the reliability of data centres as they lead to data loss and system crashes. Timely predictions of memory failures allow for taking preventive measures such as server migration and…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-12-21 Jasmin Bogatinovski , Qiao Yu , Jorge Cardoso , Odej Kao

Motivation: Detection of structural variants (SV) from the alignment of sample DNA reads to the reference genome is an important problem in understanding human diseases. Long reads that can span repeat regions, along with an accurate…

Genomics · Quantitative Biology 2023-01-25 Dhaivat Joshi , Suhas Diggavi , Mark J. P. Chaisson , Sreeram Kannan

We propose a simplified model of attention which is applicable to feed-forward neural networks and demonstrate that the resulting model can solve the synthetic "addition" and "multiplication" long-term memory problems for sequence lengths…

Machine Learning · Computer Science 2016-09-21 Colin Raffel , Daniel P. W. Ellis

Recent literature on fine-tuning Large Language Models highlights a fundamental debate. While Full Fine-Tuning (FFT) provides the representational plasticity required for high-entropy knowledge injection, Low-Rank Adaptation (LoRA) can…

Computation and Language · Computer Science 2026-05-19 Haozhan Tang , Xiuqi Zhu , Xinyin Zhang , Boxun Li , Virginia Smith , Kevin Kuo

Low-Rank Adaptation (LoRA) has become the leading Parameter-Efficient Fine-Tuning (PEFT) method for Large Language Models (LLMs), as it significantly reduces GPU memory usage while maintaining competitive fine-tuned model quality on…

Machine Learning · Computer Science 2025-10-02 Zhanda Zhu , Qidong Su , Yaoyao Ding , Kevin Song , Shang Wang , Gennady Pekhimenko

Convolution models with long filters have demonstrated state-of-the-art reasoning abilities in many long-sequence tasks but lag behind the most optimized Transformers in wall-clock time. A major bottleneck is the Fast Fourier Transform…

Machine Learning · Computer Science 2023-11-13 Daniel Y. Fu , Hermann Kumbong , Eric Nguyen , Christopher Ré

In medical contexts, the imbalanced data distribution in long-tailed datasets, due to scarce labels for rare diseases, greatly impairs the diagnostic accuracy of deep learning models. Recent multimodal text-image supervised foundation…

Computer Vision and Pattern Recognition · Computer Science 2024-08-28 Sirui Li , Li Lin , Yijin Huang , Pujin Cheng , Xiaoying Tang

Sequence alignment is a memory bound computation whose performance in modern systems is limited by the memory bandwidth bottleneck. Processing-in-memory architectures alleviate this bottleneck by providing the memory with computing…

Hardware Architecture · Computer Science 2023-03-28 Safaa Diab , Amir Nassereldine , Mohammed Alser , Juan Gómez-Luna , Onur Mutlu , Izzat El Hajj

We propose Sparse Sinkhorn Attention, a new efficient and sparse method for learning to attend. Our method is based on differentiable sorting of internal representations. Concretely, we introduce a meta sorting network that learns to…

Machine Learning · Computer Science 2020-02-27 Yi Tay , Dara Bahri , Liu Yang , Donald Metzler , Da-Cheng Juan

Prior parameter-efficient fine-tuning (PEFT) algorithms reduce memory usage and computational costs of fine-tuning large neural network models by training only a few additional adapter parameters, rather than the entire model. However, the…

Machine Learning · Computer Science 2025-03-12 Sunghyeon Woo , Sol Namkung , Sunwoo Lee , Inho Jeong , Beomseok Kim , Dongsuk Jeon

Post-training algorithms such as Supervised Fine-Tuning (SFT) and Reinforcement Fine-Tuning (RFT) are widely used to adapt (multimodal) large language models to downstream tasks. While effective at task adaptation, their impact on retaining…

Computation and Language · Computer Science 2026-03-06 Zhihao Zhang , Qiaole Dong , Qi Zhang , Jun Zhao , Enyu Zhou , Zhiheng Xi , Senjie Jin , Xiaoran Fan , Yuhao Zhou , Mingqi Wu , Yanwei Fu , Tao Ji , Tao Gui , Xuanjing Huang , Kai Chen

The "pretrain-then-finetune" paradigm is commonly adopted in the deployment of large language models. Low-Rank Adaptation (LoRA), a parameter-efficient fine-tuning method, is often employed to adapt a base model to a multitude of tasks,…

Summary: Longer sequencing reads, with at least 200 bases per template are now common. While traditional aligners have adopted new strategies to improve the mapping of longer reads, aligners specific to bisulfite-sequencing were optimized…

Genomics · Quantitative Biology 2014-05-14 Brent S. Pedersen , Kenneth Eyring , Subhajyoti De , Ivana V. Yang , David A. Schwartz

In Sequential Recommendation Systems (SRSs), Transformer models have demonstrated remarkable performance but face computational and memory cost challenges, especially when modeling long-term user behavior sequences. Due to its quadratic…

Information Retrieval · Computer Science 2026-03-25 Juntao Hu , Wei Zhou , Haini Cai , Xiao Du , Huayi Shen , Junhao Wen

In recent years, continual learning with pre-training (CLPT) has received widespread interest, instead of its traditional focus of training from scratch. The use of strong pre-trained models (PTMs) can greatly facilitate knowledge transfer…

Computer Vision and Pattern Recognition · Computer Science 2024-08-16 Gengwei Zhang , Liyuan Wang , Guoliang Kang , Ling Chen , Yunchao Wei

Efficiently training LLMs with long sequences is important yet challenged by the massive computation and memory requirements. Sequence parallelism has been proposed to tackle these problems, but existing methods suffer from scalability or…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-06-27 Diandian Gu , Peng Sun , Qinghao Hu , Ting Huang , Xun Chen , Yingtong Xiong , Guoteng Wang , Qiaoling Chen , Shangchun Zhao , Jiarui Fang , Yonggang Wen , Tianwei Zhang , Xin Jin , Xuanzhe Liu

Cloud data warehouses bill compute based on slot-time consumed. In shared multi-tenant environments, query cost is highly variable and hard to estimate before execution, causing budget overruns and degraded scheduling. Static query-planner…

Databases · Computer Science 2026-04-23 Prashant Kumar Pathak