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Coarse-to-fine models and cascade segmentation architectures are widely adopted to solve the problem of large scale variations in medical image segmentation. However, those methods have two primary limitations: the first-stage segmentation…

Computer Vision and Pattern Recognition · Computer Science 2021-02-12 Jiahao Xie , Sheng Zhang , Jianwei Lu , Ye Luo

Single cell segmentation is critical and challenging in live cell imaging data analysis. Traditional image processing methods and tools require time-consuming and labor-intensive efforts of manually fine-tuning parameters. Slight variations…

Quantitative Methods · Quantitative Biology 2019-04-24 Weikang Wang , David A. Taft , Yi-Jiun Chen , Jingyu Zhang , Callen T. Wallace , Min Xu , Simon C. Watkins , Jianhua Xing

In recent years, Convolutional Neural Networks (CNNs) have become the state-of-the-art method for biomedical image analysis. However, these networks are usually trained in a supervised manner, requiring large amounts of labelled training…

Computer Vision and Pattern Recognition · Computer Science 2020-11-24 Nastassya Horlava , Alisa Mironenko , Sebastian Niehaus , Sebastian Wagner , Ingo Roeder , Nico Scherf

The presence of certain clinical dermoscopic features within a skin lesion may indicate melanoma, and automatically detecting these features may lead to more quantitative and reproducible diagnoses. We reformulate the task of classifying…

Computer Vision and Pattern Recognition · Computer Science 2019-03-28 Jeremy Kawahara , Ghassan Hamarneh

Accurate segmentation of 3-D cell nuclei in microscopy images is essential for the study of nuclear organization, gene expression, and cell morphodynamics. Current image segmentation methods are challenged by the complexity and variability…

Image and Video Processing · Electrical Eng. & Systems 2022-03-18 Sundaresh Ram , Jeffrey J. Rodriguez

Medical imaging is a cornerstone of therapy and diagnosis in modern medicine. However, the choice of imaging modality for a particular theranostic task typically involves trade-offs between the feasibility of using a particular modality…

Computer Vision and Pattern Recognition · Computer Science 2022-07-22 Mayur Mallya , Ghassan Hamarneh

Accurate microscopic medical image segmentation plays a crucial role in diagnosing various cancerous cells and identifying tumors. Driven by advancements in deep learning, convolutional neural networks (CNNs) and transformer-based models…

Computer Vision and Pattern Recognition · Computer Science 2025-06-17 Daniya Najiha Abdul Kareem , Abdul Hannan , Mubashir Noman , Jean Lahoud , Mustansar Fiaz , Hisham Cholakkal

We propose a software platform that integrates methods and tools for multi-objective parameter auto- tuning in tissue image segmentation workflows. The goal of our work is to provide an approach for improving the accuracy of nucleus/cell…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-10-09 Luis F. R. Taveira , Tahsin Kurc , Alba C. M. A. Melo , Jun Kong , Erich Bremer , Joel H. Saltz , George Teodoro

Diffusion models have shown impressive performance for generative modelling of images. In this paper, we present a novel semantic segmentation method based on diffusion models. By modifying the training and sampling scheme, we show that…

Computer Vision and Pattern Recognition · Computer Science 2021-12-28 Julia Wolleb , Robin Sandkühler , Florentin Bieder , Philippe Valmaggia , Philippe C. Cattin

The locations of different mRNA molecules can be revealed by multiplexed in situ RNA detection. By assigning detected mRNA molecules to individual cells, it is possible to identify many different cell types in parallel. This in turn enables…

Information Theory · Computer Science 2023-12-08 Axel Andersson , Andrea Behanova , Carolina Wählby , Filip Malmberg

To segment 4K or 6K ultra high-resolution images needs extra computation consideration in image segmentation. Common strategies, such as down-sampling, patch cropping, and cascade model, cannot address well the balance issue between…

Computer Vision and Pattern Recognition · Computer Science 2025-02-24 Tiancheng Shen , Yuechen Zhang , Lu Qi , Jason Kuen , Xingyu Xie , Jianlong Wu , Zhe Lin , Jiaya Jia

Medical imaging has witnessed remarkable progress but usually requires a large amount of high-quality annotated data which is time-consuming and costly to obtain. To alleviate this burden, semi-supervised learning has garnered attention as…

Computer Vision and Pattern Recognition · Computer Science 2023-07-24 Qingyue Wei , Lequan Yu , Xianhang Li , Wei Shao , Cihang Xie , Lei Xing , Yuyin Zhou

We propose, analyze and realize a variational multiclass segmentation scheme that partitions a given image into multiple regions exhibiting specific properties. Our method determines multiple functions that encode the segmentation regions…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Nadja Gruber , Johannes Schwab , Sebastien Court , Elke Gizewski , Markus Haltmeier

Medical image segmentation remains challenging due to limited annotations for training, ambiguous anatomical features, and domain shifts. While vision-language models such as CLIP offer strong cross-modal representations, their potential…

Computer Vision and Pattern Recognition · Computer Science 2026-02-25 Taha Koleilat , Hojat Asgariandehkordi , Omid Nejati Manzari , Berardino Barile , Yiming Xiao , Hassan Rivaz

Deep neural networks usually require accurate and a large number of annotations to achieve outstanding performance in medical image segmentation. One-shot segmentation and weakly-supervised learning are promising research directions that…

Image and Video Processing · Electrical Eng. & Systems 2021-11-23 Wenhui Lei , Qi Su , Ran Gu , Na Wang , Xinglong Liu , Guotai Wang , Xiaofan Zhang , Shaoting Zhang

Medical image segmentation is particularly critical as a prerequisite for relevant quantitative analysis in the treatment of clinical diseases. For example, in clinical cervical cancer radiotherapy, after acquiring subabdominal MRI images,…

Image and Video Processing · Electrical Eng. & Systems 2023-06-30 Yu Xiao , Xin Yang , Sijuan Huang , Lihua Guo

Despite the superior performance of Deep Learning (DL) on numerous segmentation tasks, the DL-based approaches are notoriously overconfident about their prediction with highly polarized label probability. This is often not desirable for…

Image and Video Processing · Electrical Eng. & Systems 2021-12-14 Sungmin Hong , Anna K. Bonkhoff , Andrew Hoopes , Martin Bretzner , Markus D. Schirmer , Anne-Katrin Giese , Adrian V. Dalca , Polina Golland , Natalia S. Rost

Deep learning models have shown promising performance for cell nucleus segmentation in the field of pathology image analysis. However, training a robust model from multiple domains remains a great challenge for cell nucleus segmentation.…

Image and Video Processing · Electrical Eng. & Systems 2024-03-12 Dawei Fan , Yifan Gao , Jiaming Yu , Yanping Chen , Wencheng Li , Chuancong Lin , Kaibin Li , Changcai Yang , Riqing Chen , Lifang Wei

Cell individualization has a vital role in digital pathology image analysis. Deep Learning is considered as an efficient tool for instance segmentation tasks, including cell individualization. However, the precision of the Deep Learning…

Image and Video Processing · Electrical Eng. & Systems 2022-08-09 Huaqian Wu , Nicolas Souedet , Zhenzhen You , Caroline Jan , Cédric Clouchoux , Thierry Delzescaux

Segmentation of tumors in brain MRI images is a challenging task, where most recent methods demand large volumes of data with pixel-level annotations, which are generally costly to obtain. In contrast, image-level annotations, where only…

Image and Video Processing · Electrical Eng. & Systems 2019-11-07 Sergey Pavlov , Alexey Artemov , Maksim Sharaev , Alexander Bernstein , Evgeny Burnaev