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Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive decline and widespread epigenetic dysregulation in the brain. DNA methylation, as a stable yet dynamic epigenetic modification,…

Genomics · Quantitative Biology 2026-01-05 Gang Qu , Guanghao Li , Zhongming Zhao

Limited labeled data makes it hard to train models from scratch in medical domain, and an important paradigm is pre-training and then fine-tuning. Large pre-trained models contain rich representations, which can be adapted to downstream…

Computer Vision and Pattern Recognition · Computer Science 2023-07-20 Along He , Kai Wang , Zhihong Wang , Tao Li , Huazhu Fu

The ability to predict the future trajectory of a patient is a key step toward the development of therapeutics for complex diseases such as Alzheimer's disease (AD). However, most machine learning approaches developed for prediction of…

In this paper, we introduce Attention Prompt Tuning (APT) - a computationally efficient variant of prompt tuning for video-based applications such as action recognition. Prompt tuning approaches involve injecting a set of learnable prompts…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Wele Gedara Chaminda Bandara , Vishal M. Patel

Multiple instance learning (MIL) has emerged as a popular method for classifying histopathology whole slide images (WSIs). However, existing approaches typically rely on pre-trained models from large natural image datasets, such as…

Computer Vision and Pattern Recognition · Computer Science 2023-03-24 Yi Lin , Zhongchen Zhao , Zhengjie ZHU , Lisheng Wang , Kwang-Ting Cheng , Hao Chen

Accurate modeling of cognitive decline in Alzheimer's disease is essential for early stratification and personalized management. While tabular predictors provide robust markers of global risk, their ability to capture subtle brain changes…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 Nathaniel Putera , Daniel Vilet Rodríguez , Noah Videcrantz , Julia Machnio , Mostafa Mehdipour Ghazi

This work proposes POMP, a prompt pre-training method for vision-language models. Being memory and computation efficient, POMP enables the learned prompt to condense semantic information for a rich set of visual concepts with over…

Computer Vision and Pattern Recognition · Computer Science 2023-10-10 Shuhuai Ren , Aston Zhang , Yi Zhu , Shuai Zhang , Shuai Zheng , Mu Li , Alex Smola , Xu Sun

As shown in computer vision, the power of deep learning lies in automatically learning relevant and powerful features for any perdition task, which is made possible through end-to-end architectures. However, deep learning approaches applied…

Computer Vision and Pattern Recognition · Computer Science 2018-10-02 Soheil Esmaeilzadeh , Dimitrios Ioannis Belivanis , Kilian M. Pohl , Ehsan Adeli

The identification of Alzheimer's disease (AD) and its early stages using structural magnetic resonance imaging (MRI) has been attracting the attention of researchers. Various data-driven approaches have been introduced to capture subtle…

Artificial Intelligence · Computer Science 2021-08-11 Changhyun Park , Heung-Il Suk

Deep machine learning models including Convolutional Neural Networks (CNN) have been successful in the detection of Mild Cognitive Impairment (MCI) using medical images, questionnaires, and videos. This paper proposes a novel Multi-branch…

Computer Vision and Pattern Recognition · Computer Science 2024-01-08 Jian Sun , Hiroko H. Dodge , Mohammad H. Mahoor

Prompt learning as a parameter-efficient method that has been widely adopted to adapt Vision-Language Models (VLMs) to downstream tasks. While hard-prompt design requires domain expertise and iterative optimization, soft-prompt methods rely…

Computer Vision and Pattern Recognition · Computer Science 2025-05-26 Zherui Zhang , Jiaxin Wu , Changwei Wang , Rongtao Xu , Longzhao Huang , Wenhao Xu , Wenbo Xu , Li Guo , Shibiao Xu

Detection of Alzheimer's Disease (AD) from neuroimaging data such as MRI through machine learning has been a subject of intense research in recent years. Recent success of deep learning in computer vision has progressed such research…

Computer Vision and Pattern Recognition · Computer Science 2019-06-05 Naimul Mefraz Khan , Marcia Hon , Nabila Abraham

Visual Attention Prediction (VAP) is a significant and imperative issue in the field of computer vision. Most of existing VAP methods are based on deep learning. However, they do not fully take advantage of the low-level contrast features…

Computer Vision and Pattern Recognition · Computer Science 2021-03-10 Yuan Yuan , Hailong Ning , Xiaoqiang Lu

The large-scale pre-trained vision language models (VLM) have shown remarkable domain transfer capability on natural images. However, it remains unknown whether this capability can also apply to the medical image domain. This paper…

Computer Vision and Pattern Recognition · Computer Science 2023-02-08 Ziyuan Qin , Huahui Yi , Qicheng Lao , Kang Li

Early diagnosis of dementia, particularly in the prodromal stage (i.e., mild cognitive impairment, or MCI), has become a research and clinical priority but remains challenging. Automated analysis of the drawing process has been studied as a…

Signal Processing · Electrical Eng. & Systems 2022-11-17 Yasunori Yamada , Masatomo Kobayashi , Kaoru Shinkawa , Miyuki Nemoto , Miho Ota , Kiyotaka Nemoto , Tetsuaki Arai

Pretrained biomedical vision-language models (VLMs) such as BioMedCLIP perform well on average but often degrade on challenging modalities where inter-class margins are small and acquisition-specific variations are pronounced, especially…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Mainak Singha , Tanisha Gupta , Ankit Jha , Muhammad Haris Khan , Sayantani Ghosh , Biplab Banerjee

Alzheimer's disease (AD) progresses through distinct stages, from early mild cognitive impairment (EMCI) to late mild cognitive impairment (LMCI) and eventually to AD. Accurate identification of these stages, especially distinguishing LMCI…

Computer Vision and Pattern Recognition · Computer Science 2025-01-13 Aswini Kumar Patra , Soraisham Elizabeth Devi , Tejashwini Gajurel

State-of-the-art deep neural networks are still struggling to address the catastrophic forgetting problem in continual learning. In this paper, we propose one simple paradigm (named as S-Prompting) and two concrete approaches to highly…

Computer Vision and Pattern Recognition · Computer Science 2023-03-21 Yabin Wang , Zhiwu Huang , Xiaopeng Hong

The vision-language pre-training has enabled deep models to make a huge step forward in generalizing across unseen domains. The recent learning method based on the vision-language pre-training model is a great tool for domain generalization…

Computer Vision and Pattern Recognition · Computer Science 2024-04-30 Liyuan Wang , Yan Jin , Zhen Chen , Jinlin Wu , Mengke Li , Yang Lu , Hanzi Wang

Whole slide pathology image classification presents challenges due to gigapixel image sizes and limited annotation labels, hindering model generalization. This paper introduces a prompt learning method to adapt large vision-language models…