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Multimodal large language models (MLLMs) have advanced clinical tasks for common conditions, but their performance on rare diseases remains largely untested. In rare-disease scenarios, clinicians often lack prior clinical knowledge, forcing…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Junzhi Ning , Jiashi Lin , Yingying Fang , Wei Li , Jiyao Liu , Cheng Tang , Chenglong Ma , Wenhao Tang , Tianbin Li , Ziyan Huang , Guang Yang , Junjun He

Deep learning has achieved significant breakthroughs in medical imaging, but these advancements are often dependent on large, well-annotated datasets. However, obtaining such datasets poses a significant challenge, as it requires…

Computer Vision and Pattern Recognition · Computer Science 2025-04-17 Siteng Ma , Honghui Du , Yu An , Jing Wang , Qinqin Wang , Haochang Wu , Aonghus Lawlor , Ruihai Dong

Large language models (LLMs) have a transformative impact on a variety of scientific tasks across disciplines including biology, chemistry, medicine, and physics. However, ensuring the safety alignment of these models in scientific research…

We present MedPI, a high-dimensional benchmark for evaluating large language models (LLMs) in patient-clinician conversations. Unlike single-turn question-answer (QA) benchmarks, MedPI evaluates the medical dialogue across 105 dimensions…

Computation and Language · Computer Science 2026-01-09 Diego Fajardo V. , Oleksii Proniakin , Victoria-Elisabeth Gruber , Razvan Marinescu

The advancement of artificial intelligence in oral healthcare relies on the availability of large-scale multimodal datasets that capture the complexity of clinical practice. In this paper, we present a comprehensive multimodal dataset,…

Computer Vision and Pattern Recognition · Computer Science 2025-11-10 Haoxin Lv , Ijazul Haq , Jin Du , Jiaxin Ma , Binnian Zhu , Xiaobing Dang , Chaoan Liang , Ruxu Du , Yingjie Zhang , Muhammad Saqib

Large Language Models (LLMs) have emerged as a potential solution to assist digital health development with patient education, commonly medication-related enquires. We trained and validated Med-Pal, a medication domain-specific LLM-chatbot…

MLLMs have recently become a focal point in the field of artificial intelligence research. Building on the strong capabilities of LLMs, MLLMs are adept at addressing complex multi-modal tasks. With the release of GPT-4, MLLMs have gained…

Machine Learning · Computer Science 2025-05-01 Jiarui Ye , Hao Tang

The rapid evolution of Large Language Models' has underscored the need for evaluation frameworks that are globally applicable, flexible, and modular, and that support a wide range of tasks, model types, and linguistic settings. We introduce…

Computation and Language · Computer Science 2026-03-06 Samridhi Raj Sinha , Rajvee Sheth , Abhishek Upperwal , Mayank Singh

Medical Multimodal Large Language Models (MLLMs) have demonstrated remarkable capabilities across diverse healthcare tasks. However, current post-training strategies, such as supervised fine-tuning and reinforcement learning, heavily depend…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Dunyuan Xu , Xikai Yang , Juzheng Miao , Yaoqian Li , Jinpeng Li , Pheng-Ann Heng

Deploying Large Language Models (LLMs) in medical applications requires fact-checking capabilities to ensure patient safety and regulatory compliance. We introduce MedFact, a challenging Chinese medical fact-checking benchmark with 2,116…

Computation and Language · Computer Science 2025-11-18 Jiayi He , Yangmin Huang , Qianyun Du , Xiangying Zhou , Zhiyang He , Jiaxue Hu , Xiaodong Tao , Lixian Lai

As large language models (LLMs) become increasingly integrated into clinical decision-making, ensuring transparent and trustworthy reasoning is essential. However, existing evaluation strategies of LLMs' medical reasoning capability either…

Evaluating the multilingual and multicultural capabilities of Large Language Models (LLMs) is essential for their global utility. However, current benchmarks face three critical limitations: (1) fragmented evaluation dimensions that often…

Most medical multimodal benchmarks focus on static tasks such as image question answering, report generation, and plain-language rewriting. Patient education is more demanding: systems must identify relevant evidence across images, show…

Artificial Intelligence · Computer Science 2026-04-17 Zonghai Yao , Zhipeng Tang , Chengtao Lin , Xiong Luo , Benlu Wang , Juncheng Huang , Chin Siang Ong , Hong Yu

METHODS: First, a set of evaluation criteria is designed based on a comprehensive literature review. Second, existing candidate criteria are optimized for using a Delphi method by five experts in medicine and engineering. Third, three…

Computation and Language · Computer Science 2023-05-15 Jie Xu , Lu Lu , Sen Yang , Bilin Liang , Xinwei Peng , Jiali Pang , Jinru Ding , Xiaoming Shi , Lingrui Yang , Huan Song , Kang Li , Xin Sun , Shaoting Zhang

There is vivid research on adapting Large Language Models (LLMs) to perform a variety of tasks in high-stakes domains such as healthcare. Despite their popularity, there is a lack of understanding of the extent and contributing factors that…

Computation and Language · Computer Science 2024-06-07 Anand Subramanian , Viktor Schlegel , Abhinav Ramesh Kashyap , Thanh-Tung Nguyen , Vijay Prakash Dwivedi , Stefan Winkler

Despite impressive performance on standard benchmarks, multimodal large language models (MLLMs) face critical challenges in real-world clinical environments where medical images inevitably suffer various quality degradations. Existing…

Computer Vision and Pattern Recognition · Computer Science 2026-03-10 Jiyao Liu , Junzhi Ning , Chenglong Ma , Wanying Qu , Jianghan Shen , Siqi Luo , Jinjie Wei , Jin Ye , Pengze Li , Tianbin Li , Jiashi Lin , Hongming Shan , Xinzhe Luo , Xiaohong Liu , Lihao Liu , Junjun He , Ningsheng Xu

Learned representations of scientific documents can serve as valuable input features for downstream tasks without further fine-tuning. However, existing benchmarks for evaluating these representations fail to capture the diversity of…

Computation and Language · Computer Science 2023-11-14 Amanpreet Singh , Mike D'Arcy , Arman Cohan , Doug Downey , Sergey Feldman

Multimodal large language models (LLMs) are increasingly used to generate dermatology diagnostic narratives directly from images. However, reliable evaluation remains the primary bottleneck for responsible clinical deployment. We introduce…

Computer Vision and Pattern Recognition · Computer Science 2026-01-13 Yuhao Shen , Jiahe Qian , Shuping Zhang , Zhangtianyi Chen , Tao Lu , Juexiao Zhou

This paper introduces LalaEval, a holistic framework designed for the human evaluation of domain-specific large language models (LLMs). LalaEval proposes a comprehensive suite of end-to-end protocols that cover five main components…

Human-Computer Interaction · Computer Science 2024-08-27 Chongyan Sun , Ken Lin , Shiwei Wang , Hulong Wu , Chengfei Fu , Zhen Wang

Hundreds of benchmarks dedicated to evaluating large models have been presented over the past few years. However, most of them remain closed-ended and are prone to overfitting due to the potential data contamination. Moreover, the…

Computer Vision and Pattern Recognition · Computer Science 2026-02-02 Zijian Chen , Yuze Sun , Yuan Tian , Wenjun Zhang , Guangtao Zhai