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Doping control is an essential component of anti-doping organizations for protecting clean sports competitions. Since 2009, this mission has been complemented worldwide by the Athlete Biological Passport (ABP), used to monitor athletes'…

Methodology · Statistics 2024-04-22 Nina Deliu , Brunero Liseo

A rigorous Bayesian formulation of the inverse doping profile problem in infinite dimensions for a stationary linearized unipolar drift-diffusion model for semiconductor devices is given. The goal is to estimate the posterior probability…

Numerical Analysis · Mathematics 2024-08-22 Leila Taghizadeh , Ansgar Jüngel

The increase in the collection of biological data allows for the individual and longitudinal monitoring of hematological or urine biomarkers. However, identifying abnormal behavior in these biological sequences is not trivial. Moreover, the…

Anti-doping programs rely on biological testing to detect performance-enhancing drugs, but such testing costs over $800 per sample and is limited by short detection windows for many prohibited substances. These constraints leave large…

Machine Learning · Computer Science 2026-04-27 Blessed Madukoma , Prasenjit Mitra

Purpose. Athlete monitoring is constrained by small cohorts, heterogeneous biomarker scales, limited feasibility of repeated sampling, and the lack of reliable injury ground truth. These limitations reduce the interpretability and utility…

Variable selection has played a critical role in modern statistical learning and scientific discoveries. Numerous regularization and Bayesian variable selection methods have been developed in the past two decades for variable selection, but…

Methodology · Statistics 2024-03-04 Travis Canida , Hongjie Ke , Shuo Chen , Zhenayo Ye , Tianzhou Ma

Precision medicine stands as a transformative approach in healthcare, offering tailored treatments that can enhance patient outcomes and reduce healthcare costs. As understanding of complex disease improves, clinical trials are being…

Methodology · Statistics 2024-05-15 Lara Maleyeff , Shirin Golchi , Erica E. M. Moodie , Marie Hudson

Heterogeneity is a dominant factor in the behaviour of many biological processes. Despite this, it is common for mathematical and statistical analyses to ignore biological heterogeneity as a source of variability in experimental data.…

The increasing size of data sets has lead to variable selection in regression becoming increasingly important. Bayesian approaches are attractive since they allow uncertainty about the choice of variables to be formally included in the…

Computation · Statistics 2014-12-30 Jim Griffin , Krzysztof Latuszynski , Mark Steel

Intensive longitudinal biomarker data are increasingly common in scientific studies that seek temporally granular understanding of the role of behavioral and physiological factors in relation to outcomes of interest. Intensive longitudinal…

Methodology · Statistics 2024-01-17 Mingyan Yu , Zhenke Wu , Margaret Hicken , Michael R. Elliott

The use of statistical methods in sport analytics has gained a rapidly growing interest over the last decade, and nowadays is common practice. In particular, the interest in understanding and predicting an athlete's performance throughout…

Methodology · Statistics 2021-01-21 Patric Dolmeta , Raffaele Argiento , Silvia Montagna

The assessment of imaging biomarkers is critical for advancing precision medicine and improving disease characterization. Despite the availability of methods to derive disease heterogeneity metrics in imaging studies, a robust framework for…

Statistical methodology is proposed for comparing unlabeled marked point sets, with an application to aligning steroid molecules in chemoinformatics. Methods from statistical shape analysis are combined with techniques for predicting random…

Applications · Statistics 2012-03-02 Irina Czogiel , Ian L. Dryden , Christopher J. Brignell

Sports officials around the world are facing incredible challenges due to the unfair means of practices performed by the athletes to improve their performance in the game. It includes the intake of hormonal based drugs or transfusion of…

In many clinical and epidemiological studies, collecting longitudinal measurements together with time-to-event outcomes is essential. Accurately estimating the association between longitudinal markers and event risks, as well as identifying…

Longitudinal biomarker data and health outcomes are routinely collected in many studies to assess how biomarker trajectories predict health outcomes. Existing methods primarily focus on mean biomarker profiles, treating variability as a…

This paper presents a Bayesian method for identification of jump Markov linear system parameters. A primary motivation is to provide accurate quantification of parameter uncertainty without relying on asymptotic in data-length arguments. To…

Methodology · Statistics 2021-02-11 Mark P. Balenzuela , Adrian G. Wills , Christopher Renton , Brett Ninness

In immunological studies, the characterization of small, functionally distinct cell subsets from blood and tissue is crucial to decipher system level biological changes. An increasing number of studies rely on assays that provide…

Statistical models can involve implicitly defined quantities, such as solutions to nonlinear ordinary differential equations (ODEs), that unavoidably need to be numerically approximated in order to evaluate the model. The approximation…

Computation · Statistics 2024-09-16 Juho Timonen , Nikolas Siccha , Ben Bales , Harri Lähdesmäki , Aki Vehtari

We develop Bayesian models for density regression with emphasis on discrete outcomes. The problem of density regression is approached by considering methods for multivariate density estimation of mixed scale variables, and obtaining…

Methodology · Statistics 2019-08-14 Georgios Papageorgiou
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