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Adverse drug-drug interactions~(DDIs) can compromise the effectiveness of concurrent drug administration, posing a significant challenge in healthcare. As the development of new drugs continues, the potential for unknown adverse effects…

Computation and Language · Computer Science 2024-03-14 Fangqi Zhu , Yongqi Zhang , Lei Chen , Bing Qin , Ruifeng Xu

Predicting drug response in patients from preclinical data remains a major challenge in precision oncology due to the substantial biological gap between in vitro cell lines and patient tumors. Rather than aiming to improve absolute in vitro…

Machine Learning · Computer Science 2026-03-18 Camille Jimenez Cortes , Philippe Lalanda , German Vega

Given the vastness of chemical space and the ongoing emergence of previously uncharacterized proteins, zero-shot compound-protein interaction (CPI) prediction better reflects the practical challenges and requirements of real-world drug…

Machine Learning · Computer Science 2025-07-29 Hongzhi Zhang , Zhonglie Liu , Kun Meng , Jiameng Chen , Jia Wu , Bo Du , Di Lin , Yan Che , Wenbin Hu

Deep learning-based drug response prediction (DRP) methods can accelerate the drug discovery process and reduce R\&D costs. Although the mainstream methods achieve high accuracy in predicting response regression values, the regression-aware…

Biomolecules · Quantitative Biology 2023-12-19 Kun Li , Wenbin Hu

Multi-source Domain Adaptation (MDA) aims to transfer predictive models from multiple, fully-labeled source domains to an unlabeled target domain. However, in many applications, relevant labeled source datasets may not be available, and…

Computer Vision and Pattern Recognition · Computer Science 2021-09-28 Xiangyu Yue , Zangwei Zheng , Colorado Reed , Hari Prasanna Das , Kurt Keutzer , Alberto Sangiovanni Vincentelli

Deep learning (DL) has emerged as a powerful tool for accelerated MRI reconstruction, but often necessitates a database of fully-sampled measurements for training. Recent self-supervised and unsupervised learning approaches enable training…

Image and Video Processing · Electrical Eng. & Systems 2023-11-30 Burhaneddin Yaman , Seyed Amir Hossein Hosseini , Mehmet Akçakaya

Zero-shot learning has received increasing interest as a means to alleviate the often prohibitive expense of annotating training data for large scale recognition problems. These methods have achieved great success via learning intermediate…

Machine Learning · Computer Science 2015-03-27 Yanwei Fu , Yongxin Yang , Tim Hospedales , Tao Xiang , Shaogang Gong

Accurate prediction of drug response in precision medicine requires models that capture how specific chemical substructures interact with cellular pathway states. However, most existing deep learning approaches treat chemical and…

Machine Learning · Computer Science 2026-04-14 Yewon Han , Sunghyun Kim , Eunyi Jeong , Sungkyung Lee , Seokwoo Yun , Sangsoo Lim

Source-free domain adaptation (SFDA) aims to adapt a source model trained on a fully-labeled source domain to a related but unlabeled target domain. While the source model is a key avenue for acquiring target pseudolabels, the generated…

Computer Vision and Pattern Recognition · Computer Science 2024-10-04 Wenyu Zhang , Li Shen , Chuan-Sheng Foo

The performance of automatic speech recognition models often degenerates on domains not covered by the training data. Domain adaptation can address this issue, assuming the availability of the target domain data in the target language.…

Audio and Speech Processing · Electrical Eng. & Systems 2024-12-17 Han Zhu , Gaofeng Cheng , Qingwei Zhao , Pengyuan Zhang

In this report we present an unsupervised image registration framework, using a pre-trained deep neural network as a feature extractor. We refer this to zero-shot learning, due to nonoverlap between training and testing dataset (none of the…

Computer Vision and Pattern Recognition · Computer Science 2019-08-20 Avinash Kori , Ganapathi Krishnamurthi

In some of object recognition problems, labeled data may not be available for all categories. Zero-shot learning utilizes auxiliary information (also called signatures) describing each category in order to find a classifier that can…

Computer Vision and Pattern Recognition · Computer Science 2016-06-01 Seyed Mohsen Shojaee , Mahdieh Soleymani Baghshah

Given a new dataset D and a low compute budget, how should we choose a pre-trained model to fine-tune to D, and set the fine-tuning hyperparameters without risking overfitting, particularly if D is small? Here, we extend automated machine…

Machine Learning · Computer Science 2022-06-28 Ekrem Öztürk , Fabio Ferreira , Hadi S. Jomaa , Lars Schmidt-Thieme , Josif Grabocka , Frank Hutter

Drug-drug interaction (DDI) prediction provides a drug combination strategy for systemically effective treatment. Previous studies usually model drug information constrained on a single view such as the drug itself, leading to incomplete…

Biomolecules · Quantitative Biology 2022-03-29 Zimeng Li , Shichao Zhu , Bin Shao , Tie-Yan Liu , Xiangxiang Zeng , Tong Wang

Drug-drug interactions (DDIs) can result in various pharmacological changes, which can be categorized into different classes known as DDI events (DDIEs). In recent years, previously unobserved/unseen DDIEs have been emerging, posing a new…

Machine Learning · Computer Science 2024-08-01 Ziyan Wang , Zhankun Xiong , Feng Huang , Xuan Liu , Wen Zhang

Zero-shot domain adaptation (ZSDA) is a domain adaptation problem in the situation that labeled samples for a target task (task of interest) are only available from the source domain at training time, but for a task different from the task…

Computer Vision and Pattern Recognition · Computer Science 2024-06-28 Yu Zhe , Jun Sakuma

Zero-shot recognition (ZSR) deals with the problem of predicting class labels for target domain instances based on source domain side information (e.g. attributes) of unseen classes. We formulate ZSR as a binary prediction problem. Our…

Computer Vision and Pattern Recognition · Computer Science 2016-08-22 Ziming Zhang , Venkatesh Saligrama

Domain adaptation (DA) is the topical problem of adapting models from labelled source datasets so that they perform well on target datasets where only unlabelled or partially labelled data is available. Many methods have been proposed to…

Computer Vision and Pattern Recognition · Computer Science 2020-07-28 Da Li , Timothy Hospedales

Zero-shot domain adaptation (ZSDA) presents substantial challenges due to the lack of images in the target domain. Previous approaches leverage Vision-Language Models (VLMs) to tackle this challenge, exploiting their zero-shot learning…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Xiao Zhang , Fei Wei , Yong Wang , Wenda Zhao , Feiyi Li , Xiangxiang Chu

Deep learning (DL) applied to breast tissue segmentation in magnetic resonance imaging (MRI) has received increased attention in the last decade, however, the domain shift which arises from different vendors, acquisition protocols, and…

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