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Related papers: Preference Optimization for Molecular Language Mod…

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Large language models (LLMs) are fine-tuned using human comparison data with Reinforcement Learning from Human Feedback (RLHF) methods to make them better aligned with users' preferences. In contrast to LLMs, human preference learning has…

Computer Vision and Pattern Recognition · Computer Science 2023-11-23 Bram Wallace , Meihua Dang , Rafael Rafailov , Linqi Zhou , Aaron Lou , Senthil Purushwalkam , Stefano Ermon , Caiming Xiong , Shafiq Joty , Nikhil Naik

Despite their ability to understand chemical knowledge, large language models (LLMs) remain limited in their capacity to propose novel molecules with desired functions (e.g., drug-like properties). In addition, the molecules that LLMs…

In sequential recommendation, models recommend items based on user's interaction history. To this end, current models usually incorporate information such as item descriptions and user intent or preferences. User preferences are usually not…

The rapid development of large language model (LLM) alignment algorithms has resulted in a complex and fragmented landscape, with limited clarity on the effectiveness of different methods and their inter-connections. This paper introduces…

Learning from Preferential Feedback (LfPF) plays an essential role in training Large Language Models, as well as certain types of interactive learning agents. However, a substantial gap exists between the theory and application of LfPF…

Machine Learning · Computer Science 2024-03-29 Jonathan Colaço Carr , Prakash Panangaden , Doina Precup

The recent success in using human preferences to align large language models (LLMs) has significantly improved their performance in various downstream tasks, such as question answering, mathematical reasoning, and code generation. However,…

Machine Learning · Computer Science 2026-05-18 Xiaoqiang Lin , Arun Verma , Zhongxiang Dai , Daniela Rus , See-Kiong Ng , Bryan Kian Hsiang Low

Protein Language Models (PLMs), pre-trained on extensive evolutionary data from natural proteins, have emerged as indispensable tools for protein design. While powerful, PLMs often struggle to produce proteins with precisely specified…

Biomolecules · Quantitative Biology 2025-09-15 Long-Kai Huang , Rongyi Zhu , Bing He , Jianhua Yao

What enables large language models (LLMs) to effectively model user preferences in sequential recommendation? Our investigation reveals that existing preference-alignment approaches largely rely on binary pairwise comparisons, overlooking…

Information Retrieval · Computer Science 2026-04-20 Zhongyu Ouyang , Qianlong Wen , Chunhui Zhang , Yanfang Ye , Soroush Vosoughi

Reinforcement Learning frameworks, particularly those utilizing human annotations, have become an increasingly popular method for preference fine-tuning, where the outputs of a language model are tuned to match a certain set of behavioral…

Machine Learning · Computer Science 2025-10-21 Archie Chaudhury

Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

Alignment is a crucial step to enhance the instruction-following and conversational abilities of language models. Despite many recent work proposing new algorithms, datasets, and training pipelines, there is a lack of comprehensive studies…

Computation and Language · Computer Science 2024-10-04 Xiao Yu , Qingyang Wu , Yu Li , Zhou Yu

Large Language Models (LLMs) are increasingly used in applications where the model selects from competing third-party content, such as in LLM-powered search engines or chatbot plugins. In this paper, we introduce Preference Manipulation…

Cryptography and Security · Computer Science 2024-07-03 Fredrik Nestaas , Edoardo Debenedetti , Florian Tramèr

In the domain of complex reasoning tasks, such as mathematical reasoning, recent advancements have proposed the use of Direct Preference Optimization (DPO) to suppress output of dispreferred responses, thereby enhancing the long-chain…

Computation and Language · Computer Science 2025-10-27 Weibin Liao , Xu Chu , Yasha Wang

Language models (LMs) are pretrained to imitate internet text, including content that would violate human preferences if generated by an LM: falsehoods, offensive comments, personally identifiable information, low-quality or buggy code, and…

Computation and Language · Computer Science 2023-06-16 Tomasz Korbak , Kejian Shi , Angelica Chen , Rasika Bhalerao , Christopher L. Buckley , Jason Phang , Samuel R. Bowman , Ethan Perez

Reinforcement learning from human feedback (RLHF) has emerged as the primary method for aligning large language models (LLMs) with human preferences. While it enables LLMs to achieve human-level alignment, it often incurs significant…

Computation and Language · Computer Science 2025-03-21 Shivank Garg , Ayush Singh , Shweta Singh , Paras Chopra

Language modeling studies the probability distributions over strings of texts. It is one of the most fundamental tasks in natural language processing (NLP). It has been widely used in text generation, speech recognition, machine…

Computation and Language · Computer Science 2024-07-18 Chengwei Wei , Yun-Cheng Wang , Bin Wang , C. -C. Jay Kuo

In large language model (LLM)-based recommendation systems, direct preference optimization (DPO) effectively aligns recommendations with user preferences, requiring multi-negative objective functions to leverage abundant implicit-feedback…

Information Retrieval · Computer Science 2026-05-04 Xingyu Hu , Kai Zhang , Jiancan Wu , Shuli Wang , Chi Wang , Wenshuai Chen , Yinhua Zhu , Haitao Wang , Xingxing Wang , Xiang Wang

Optimizing chemical molecules for desired properties lies at the core of drug development. Despite initial successes made by deep generative models and reinforcement learning methods, these methods were mostly limited by the requirement of…

Machine Learning · Computer Science 2021-12-01 Shuangjia Zheng , Ying Song , Zhang Pan , Chengtao Li , Le Song , Yuedong Yang

Recent alignment methods based on Direct Preference Optimization (DPO) reformulate preference learning as supervised optimization over pairwise comparisons, offering improved efficiency and stability over reinforcement learning from human…

Machine Learning · Computer Science 2026-01-22 Yuhui Sun , Xiyao Wang , Zixi Li , YiTian Ding , Tianyang Ling , Jialuo Chen , Tianyi Yu , Zhenlong Yuan , Jinman Zhao

Direct Preference Optimization (DPO) simplifies reinforcement learning from human feedback (RLHF) for large language models (LLMs) by directly optimizing human preferences without an explicit reward model. We find that during DPO training,…

Computation and Language · Computer Science 2026-01-01 Junshu Pan , Wei Shen , Shulin Huang , Qiji Zhou , Yue Zhang
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