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The Complete Mediation Test (CMT) serves as a specialized approach of mediation analysis to assess whether an independent variable A, influences an outcome variable Y exclusively through a mediator M, without any direct effect. An…

Methodology · Statistics 2025-07-22 Yichin Tsai , Wan-Tzu Chang , Jia Jyun Sie , Cathy SJ Fann , Iebin Lian

Standard statistical methods that do not take proper account of the complexity of survey design can lead to erroneous inferences when applied to survey data due to unequal selection probabilities, clustering, and other design features. In…

Methodology · Statistics 2021-03-04 Jae-kwang Kim , J. N. K. Rao , Zhonglei Wang

The role played by the composite analogue of the log likelihood ratio in hypothesis testing and in setting confidence regions is not as prominent as it is in the canonical likelihood setting, since its asymptotic distribution depends on the…

Methodology · Statistics 2013-01-30 Nicola Lunardon

We consider tests of hypotheses when the parameters are not identifiable under the null in semiparametric models, where regularity conditions for profile likelihood theory fail. Exponential average tests based on integrated profile…

Statistics Theory · Mathematics 2009-08-25 Rui Song , Michael R. Kosorok , Jason P. Fine

Understanding the pathways whereby an intervention has an effect on an outcome is a common scientific goal. A rich body of literature provides various decompositions of the total intervention effect into pathway specific effects.…

Methodology · Statistics 2020-01-20 David Benkeser

Assessing whether two patient populations exhibit comparable event dynamics is essential for evaluating treatment equivalence, pooling data across cohorts, or comparing clinical pathways across hospitals or strategies. We introduce a…

Methodology · Statistics 2026-04-10 Zoe Kristin Lange , Maryam Farhadizadeh , Holger Dette , Nadine Binder

This paper develops a novel nonparametric significance test based on a tailored nonparametric-type projected weighting function that exhibits appealing theoretical and numerical properties. We derive the asymptotic properties of the…

Econometrics · Economics 2026-02-18 Xiaojun Song , Jichao Yuan

The theocratical properties of the power of the conventional testing hypotheses and the selection bias are usually unknown under covariate-adaptive randomized clinical trials. In the literature, most studies are based on simulations. In…

Statistics Theory · Mathematics 2021-05-04 Li-Xin Zhang

Mediation analysis seeks to infer how much of the effect of an exposure on an outcome can be attributed to specific pathways via intermediate variables or mediators. This requires identification of so-called path-specific effects. These…

Methodology · Statistics 2019-06-06 Johan Steen , Stijn Vansteelandt

Causal mediation analysis, pleiotropy analysis, and replication analysis are three highly popular genetic study designs. Although these analyses address different scientific questions, the underlying inference problems all involve…

Methodology · Statistics 2023-09-25 Ryan Sun , Zachary McCaw , Xihong Lin

We consider the problem of multiple hypothesis testing with generic side information: for each hypothesis $H_i$ we observe both a p-value $p_i$ and some predictor $x_i$ encoding contextual information about the hypothesis. For large-scale…

Methodology · Statistics 2018-07-26 Lihua Lei , William Fithian

The advantages of adaptive experiments have led to their rapid adoption in economics, other fields, as well as among practitioners. However, adaptive experiments pose challenges for causal inference. This note suggests a BOLS (batched…

Econometrics · Economics 2025-12-12 Jan Kemper , Davud Rostam-Afschar

This paper derives a new powerful test for mediation that is easy to use. Testing for mediation is empirically very important in psychology, sociology, medicine, economics and business, generating over 100,000 citations to a single key…

Econometrics · Economics 2022-01-19 Kees Jan van Garderen , Noud van Giersbergen

A method using multiple imputation and bootstrap for dealing with missing data in mediation analysis is introduced and implemented in SAS. Through simulation studies, it is shown that the method performs well for both MCAR and MAR data…

Methodology · Statistics 2014-01-10 Lijuan Wang , Zhiyong Zhang , Xin Tong

Economists are often interested in the mechanisms by which a treatment affects an outcome. We develop tests for the "sharp null of full mediation" that a treatment $D$ affects an outcome $Y$ only through a particular mechanism (or set of…

Econometrics · Economics 2026-02-23 Soonwoo Kwon , Jonathan Roth

High dimensional hypothesis test deals with models in which the number of parameters is significantly larger than the sample size. Existing literature develops a variety of individual tests. Some of them are sensitive to the dense and small…

Statistics Theory · Mathematics 2018-08-09 Cheng Zhou , Xinsheng Zhang , Wenxin Zhou , Han Liu

Mediation analysis is concerned with the decomposition of the total effect of an exposure on an outcome into the indirect effect through a given mediator, and the remaining direct effect. This is ideally done using longitudinal measurements…

Statistics Theory · Mathematics 2019-12-04 Murthy N Mittinty , Stijn Vansteelandt

Randomized experiments have become a cornerstone of evidence-based decision-making in contexts ranging from online platforms to public health. However, in experimental settings with network interference, a unit's treatment can influence…

Machine Learning · Computer Science 2025-10-22 Sadegh Shirani , Yuwei Luo , William Overman , Ruoxuan Xiong , Mohsen Bayati

We introduce a new framework for constructing tests of general semiparametric hypotheses which have nontrivial power on the $n^{-1/2}$ scale in every direction, and can be tailored to put substantial power on alternatives of importance. The…

Statistics Theory · Mathematics 2007-06-13 Peter J. Bickel , Ya'acov Ritov , Thomas M. Stoker

The general philosophy for bootstrap or permutation methods for testing hypotheses is to simulate the variation of the test statistic by generating the sampling distribution which assumes both that the null hypothesis is true, and that the…

Methodology · Statistics 2012-05-18 Anna Varvak