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Deep learning models have achieved state-of-the-art results in estimating brain age, which is an important brain health biomarker, from magnetic resonance (MR) images. However, most of these models only provide a global age prediction, and…

Image and Video Processing · Electrical Eng. & Systems 2023-08-25 Neha Gianchandani , Mahsa Dibaji , Mariana Bento , Ethan MacDonald , Roberto Souza

Brain aging, and more specifically the difference between the chronological and the biological age of a person, may be a promising biomarker for identifying neurodegenerative diseases. For this purpose accurate prediction is important but…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Kyriaki-Margarita Bintsi , Vasileios Baltatzis , Alexander Hammers , Daniel Rueckert

Brain age is the estimate of biological age derived from neuroimaging datasets using machine learning algorithms. Increasing brain age with respect to chronological age can reflect increased vulnerability to neurodegeneration and cognitive…

Quantitative Methods · Quantitative Biology 2024-02-13 Saurabh Sihag , Gonzalo Mateos , Alejandro Ribeiro

Age is an important variable to describe the expected brain's anatomy status across the normal aging trajectory. The deviation from that normative aging trajectory may provide some insights into neurological diseases. In neuroimaging,…

Computer Vision and Pattern Recognition · Computer Science 2023-04-14 Huy-Dung Nguyen , Michaël Clément , Boris Mansencal , Pierrick Coupé

Numerous studies have established that estimated brain age, as derived from statistical models trained on healthy populations, constitutes a valuable biomarker that is predictive of cognitive decline and various neurological diseases. In…

Computer Vision and Pattern Recognition · Computer Science 2019-07-02 Xinyang Feng , Zachary C. Lipton , Jie Yang , Scott A. Small , Frank A. Provenzano

Predictive modeling using structural magnetic resonance imaging (MRI) data is a prominent approach to study brain-aging. Machine learning algorithms and feature extraction methods have been employed to improve predictions and explore…

Machine Learning · Computer Science 2025-01-20 Georgios Antonopoulos , Shammi More , Simon B. Eickhoff , Federico Raimondo , Kaustubh R. Patil

Machine learning analysis of neuroimaging data can accurately predict chronological age in healthy people and deviations from healthy brain ageing have been associated with cognitive impairment and disease. Here we sought to further…

Over the years, Machine Learning models have been successfully employed on neuroimaging data for accurately predicting brain age. Deviations from the healthy brain aging pattern are associated to the accelerated brain aging and brain…

Image and Video Processing · Electrical Eng. & Systems 2023-06-23 M. Tanveer , M. A. Ganaie , Iman Beheshti , Tripti Goel , Nehal Ahmad , Kuan-Ting Lai , Kaizhu Huang , Yu-Dong Zhang , Javier Del Ser , Chin-Teng Lin

Brain age estimation from Magnetic Resonance Images (MRI) derives the difference between a subject's biological brain age and their chronological age. This is a potential biomarker for neurodegeneration, e.g. as part of Alzheimer's disease.…

Computer Vision and Pattern Recognition · Computer Science 2020-10-02 Kyriaki-Margarita Bintsi , Vasileios Baltatzis , Arinbjörn Kolbeinsson , Alexander Hammers , Daniel Rueckert

Brain age is the estimate of biological age derived from neuroimaging datasets using machine learning algorithms. Increasing \textit{brain age gap} characterized by an elevated brain age relative to the chronological age can reflect…

Machine Learning · Computer Science 2025-01-06 Saurabh Sihag , Gonzalo Mateos , Alejandro Ribeiro

The deviation between chronological age and biological age is a well-recognized biomarker associated with cognitive decline and neurodegeneration. Age-related and pathology-driven changes to brain structure are captured by various…

Machine Learning · Computer Science 2022-11-01 Saurabh Sihag , Gonzalo Mateos , Corey McMillan , Alejandro Ribeiro

Brain age has become a prominent biomarker of brain health. Yet most prior work targets whole brain age (WBA), a coarse paradigm that struggles to support tasks such as disease characterization and research on development and aging…

Computer Vision and Pattern Recognition · Computer Science 2026-02-16 Shuai Shao , Yan Wang , Shu Jiang , Shiyuan Zhao , Xinzhe Luo , Di Yang , Jiangtao Wang , Yutong Bai , Jianguo Zhang

The determination of biological brain age is a crucial biomarker in the assessment of neurological disorders and understanding of the morphological changes that occur during aging. Various machine learning models have been proposed for…

Image and Video Processing · Electrical Eng. & Systems 2023-06-12 Mansoor Ahmed , Usama Sardar , Sarwan Ali , Shafiq Alam , Murray Patterson , Imdad Ullah Khan

In computational neuroscience, there has been an increased interest in developing machine learning algorithms that leverage brain imaging data to provide estimates of "brain age" for an individual. Importantly, the discordance between brain…

Quantitative Methods · Quantitative Biology 2023-10-30 Saurabh Sihag , Gonzalo Mateos , Corey McMillan , Alejandro Ribeiro

Neuroimaging-driven prediction of brain age, defined as the predicted biological age of a subject using only brain imaging data, is an exciting avenue of research. In this work we seek to build models of brain age based on functional…

Brain age prediction using neuroimaging data has shown great potential as an indicator of overall brain health and successful aging, as well as a disease biomarker. Deep learning models have been established as reliable and efficient brain…

Computer Vision and Pattern Recognition · Computer Science 2023-10-24 Bruno Machado Pacheco , Victor Hugo Rocha de Oliveira , Augusto Braga Fernandes Antunes , Saulo Domingos de Souza Pedro , Danilo Silva

Multiple sclerosis is a chronic autoimmune disease that affects the central nervous system. Understanding multiple sclerosis progression and identifying the implicated brain structures is crucial for personalized treatment decisions.…

Chronological age of healthy people is able to be predicted accurately using deep neural networks from neuroimaging data, and the predicted brain age could serve as a biomarker for detecting aging-related diseases. In this paper, a novel 3D…

Image and Video Processing · Electrical Eng. & Systems 2021-06-08 Jian Cheng , Ziyang Liu , Hao Guan , Zhenzhou Wu , Haogang Zhu , Jiyang Jiang , Wei Wen , Dacheng Tao , Tao Liu

Brain decoding that classifies cognitive states using the functional fluctuations of the brain can provide insightful information for understanding the brain mechanisms of cognitive functions. Among the common procedures of decoding the…

Human-Computer Interaction · Computer Science 2024-07-12 Jianfei Zhu , Baichun Wei , Jiaru Tian , Feng Jiang , Chunzhi Yi
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