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This paper addresses the task of nuclei segmentation in high-resolution histopathological images. We propose an auto- matic end-to-end deep neural network algorithm for segmenta- tion of individual nuclei. A nucleus-boundary model is…

Computer Vision and Pattern Recognition · Computer Science 2020-03-18 Yuxin Cui , Guiying Zhang , Zhonghao Liu , Zheng Xiong , Jianjun Hu

Accurate segmentation and precise morphological analysis of neuronal cells in fluorescence microscopy images are crucial steps in neuroscience and biomedical imaging applications. However, this process is labor-intensive and time-consuming,…

Image and Video Processing · Electrical Eng. & Systems 2025-10-23 Banan Alnemri , Arwa Basbrain

Quantifying uncertainty in a model's predictions is important as it enables the safety of an AI system to be increased by acting on the model's output in an informed manner. This is crucial for applications where the cost of an error is…

Computer Vision and Pattern Recognition · Computer Science 2021-05-31 Aria Khoshsirat

Parkinson's Disease (PD) is the second most common neurodegenerative disease in humans. PD is characterized by the gradual loss of dopaminergic neurons in the Substantia Nigra (SN). Counting the number of dopaminergic neurons in the SN is…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Fatemeh Haghighi , Soumitra Ghosh , Hai Ngu , Sarah Chu , Han Lin , Mohsen Hejrati , Baris Bingol , Somaye Hashemifar

Whole brain segmentation from structural magnetic resonance imaging (MRI) is a prerequisite for most morphological analyses, but is computationally intense and can therefore delay the availability of image markers after scan acquisition. We…

Computer Vision and Pattern Recognition · Computer Science 2018-11-27 Abhijit Guha Roy , Sailesh Conjeti , Nassir Navab , Christian Wachinger

Modern histopathological image analysis relies on the segmentation of cell structures to derive quantitative metrics required in biomedical research and clinical diagnostics. State-of-the-art deep learning approaches predominantly apply…

Image and Video Processing · Electrical Eng. & Systems 2022-01-12 Yoav Alon , Huiyu Zhou

Nucleus segmentation and classification are the prerequisites in the workflow of digital pathology processing. However, it is very challenging due to its high-level heterogeneity and wide variations. This work proposes a deep neural network…

Image and Video Processing · Electrical Eng. & Systems 2022-12-07 Sen Yang , Jinxi Xiang , Xiyue Wang

Precise 3D segmentation of cerebral vasculature from T1-weighted contrast-enhanced (T1CE) MRI is crucial for safe neurosurgical planning. Manual delineation is time-consuming and prone to inter-observer variability, while current automated…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Mohammad Jafari Vayeghan , Niloufar Delfan , Mehdi Tale Masouleh , Mansour Parvaresh Rizi , Behzad Moshiri

Segmentation has been a major task in neuroimaging. A large number of automated methods have been developed for segmenting healthy and diseased brain tissues. In recent years, deep learning techniques have attracted a lot of attention as a…

Image and Video Processing · Electrical Eng. & Systems 2019-07-05 Jimit Doshi , Guray Erus , Mohamad Habes , Christos Davatzikos

Deep convolutional neural networks (CNNs) are state-of-the-art for semantic image segmentation, but typically require many labeled training samples. Obtaining 3D segmentations of medical images for supervised training is difficult and labor…

Computer Vision and Pattern Recognition · Computer Science 2019-07-29 Zhenlin Xu , Marc Niethammer

Though performed almost effortlessly by humans, segmenting 2D gray-scale or color images into respective regions of interest (e.g.~background, objects, or portions of objects) constitutes one of the greatest challenges in science and…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Alexandre Benatti , Luciano da F. Costa

Optical neuroimaging is a vital tool for understanding the brain structure and the connection between regions and nuclei. However, the image noise introduced in the sample preparation and the imaging system hinders the extraction of the…

Image and Video Processing · Electrical Eng. & Systems 2021-09-23 Tianfang Zhu , Yue Guan , Anan Li

Quantitative, volumetric analysis of Magnetic Resonance Imaging (MRI) is a fundamental way researchers study the brain in a host of neurological conditions including normal maturation and aging. Despite the availability of open-source brain…

Quantitative Methods · Quantitative Biology 2019-11-15 Aakash Kaku , Chaitra V. Hegde , Jeffrey Huang , Sohae Chung , Xiuyuan Wang , Matthew Young , Alireza Radmanesh , Yvonne W. Lui , Narges Razavian

In this paper, we consider the problem of automatically segmenting neuronal cells in dual-color confocal microscopy images. This problem is a key task in various quantitative analysis applications in neuroscience, such as tracing cell…

Computer Vision and Pattern Recognition · Computer Science 2017-06-01 Jianxu Chen , Sreya Banerjee , Abhinav Grama , Walter J. Scheirer , Danny Z. Chen

Convolutional neural networks (CNNs) have achieved state-of-the-art performance for automatic medical image segmentation. However, they have not demonstrated sufficiently accurate and robust results for clinical use. In addition, they are…

Computer Vision and Pattern Recognition · Computer Science 2018-07-23 Guotai Wang , Wenqi Li , Maria A. Zuluaga , Rosalind Pratt , Premal A. Patel , Michael Aertsen , Tom Doel , Anna L. David , Jan Deprest , Sebastien Ourselin , Tom Vercauteren

The anatomical location of imaging features is of crucial importance for accurate diagnosis in many medical tasks. Convolutional neural networks (CNN) have had huge successes in computer vision, but they lack the natural ability to…

Computer Vision and Pattern Recognition · Computer Science 2016-11-01 Mohsen Ghafoorian , Nico Karssemeijer , Tom Heskes , Inge van Uden , Clara Sanchez , Geert Litjens , Frank-Erik de Leeuw , Bram van Ginneken , Elena Marchiori , Bram Platel

Convolutional Neural Networks (CNNs) work very well for supervised learning problems when the training dataset is representative of the variations expected to be encountered at test time. In medical image segmentation, this premise is…

Image and Video Processing · Electrical Eng. & Systems 2021-01-26 Neerav Karani , Ertunc Erdil , Krishna Chaitanya , Ender Konukoglu

Deep learning had already demonstrated its power in medical images, including denoising, classification, segmentation, etc. All these applications are proposed to automatically analyze medical images beforehand, which brings more…

Image and Video Processing · Electrical Eng. & Systems 2020-11-05 Shao-Cheng Wen , Yu-Jen Chen , Zihao Liu , Wujie Wen , Xiaowei Xu , Yiyu Shi , Tsung-Yi Ho , Qianjun Jia , Meiping Huang , Jian Zhuang

Fully convolutional neural networks (CNNs) have proven to be effective at representing and classifying textural information, thus transforming image intensity into output class masks that achieve semantic image segmentation. In medical…

Computer Vision and Pattern Recognition · Computer Science 2019-09-12 Ali Hatamizadeh , Demetri Terzopoulos , Andriy Myronenko

This study addresses critical gaps in automated lymphoma segmentation from PET/CT images, focusing on issues often overlooked in existing literature. While deep learning has been applied for lymphoma lesion segmentation, few studies…