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X-ray computed tomography (CT) based on photon counting detectors (PCD) extends standard CT by counting detected photons in multiple energy bins. PCD data can be used to increase the contrast-to-noise ratio (CNR), increase spatial…

Image and Video Processing · Electrical Eng. & Systems 2024-02-05 Natalie M. Jadue , Madhuri Nagare , Jonathan S. Maltz , Gregery T. Buzzard , Charles A. Bouman

Photon counting CT (PCCT) has been a research focus in the last two decades. Recent studies and advancements have demonstrated that systems using semiconductor-based photon counting detectors (PCDs) have the potential to provide better…

Inferior soft-tissue contrast resolution is a major limitation of current CT scanners. The aim of the study is to improve the contrast resolution of CT scanners using dual-energy acquisition. Based on dual-energy material decomposition, the…

Medical Physics · Physics 2016-11-15 Wei Zhao , Lu Wan , Bo Zhang , Qiude Zhang , Tianye Niu

Multi-material decomposition (MMD) enables quantitative reconstruction of tissue compositions in the human body, supporting a wide range of clinical applications. However, traditional MMD typically requires spectral CT scanners and…

Computer Vision and Pattern Recognition · Computer Science 2025-05-14 Qing Wu , Hongjiang Wei , Jingyi Yu , S. Kevin Zhou , Yuyao Zhang

X-ray photon-counting detectors (PCDs) are drawing an increasing attention in recent years due to their low noise and energy discrimination capabilities. The energy/spectral dimension associated with PCDs potentially brings great benefits…

Medical Physics · Physics 2020-07-08 Mengzhou Li , David S. Rundle , Ge Wang

Photon-counting computed tomography has demonstrated significant advancements in recent years; however, micro photon-counting CT (Micro-PCCT) systems are still limited by pixel-wise detector response nonuniformity, which degrades…

Medical Physics · Physics 2026-03-31 Enze Zhou , Wenjian Li , Wenting Xu , Yuwei Lu , Shangbin Chen , Shaoyang Wang , Gang Zheng , Tianwu Xie , Qian Liu

Dual energy CT (DECT) enhances tissue characterization because it can produce images of basis materials such as soft-tissue and bone. DECT is of great interest in applications to medical imaging, security inspection and nondestructive…

Medical Physics · Physics 2018-09-05 Qiaoqiao Ding , Tianye Niu , Xiaoqun Zhang , Yong Long

X-ray photon-counting detector (PCD) offers low noise, high resolution, and spectral characterization, representing a next generation of CT and enabling new biomedical applications. It is well known that involuntary patient motion may…

Medical Physics · Physics 2022-10-20 Mengzhou Li , Chiara Lowe , Anthony Butler , Phil Butler , Ge Wang

Photon-counting computed tomography (PCCT) has emerged as a promising imaging technique, enabling spectral imaging and material decomposition (MD). However, images typically suffer from a low signal-to-noise ratio (SNR) due to constraints…

This paper proposes a novel approach to spectral computed tomography (CT) material decomposition that uses the recent advances in generative diffusion models (DMs) for inverse problems. Spectral CT and more particularly photon-counting CT…

Quantitative imaging is an important feature of spectral X-ray and CT systems, especially photon-counting CT (PCCT) imaging systems, which is achieved through material decomposition (MD) using spectral measurements. In this work, we present…

Medical Physics · Physics 2026-03-04 Sen Wang , Yirong Yang , Jooho Lee , Grant M. Stevens , Adam S. Wang

Many spectral CT applications require accurate material decomposition. Existing material decomposition algorithms are often susceptible to significant noise magnification or, in the case of one-step model-based approaches, hampered by slow…

Medical Physics · Physics 2025-07-22 Xiao Jiang , Grace J. Gang , J. Webster Stayman

Photon-counting CT (PCCT) offers improved diagnostic performance through better spatial and energy resolution, but developing high-quality image reconstruction methods that can deal with these large datasets is challenging. Model-based…

Medical Physics · Physics 2022-08-09 Alma Eguizabal , Ozan Öktem , Mats U. Persson

Spectral photon-counting X-ray CT (sCT) opens up new possibilities for the quantitative measurement of materials in an object, compared to conventional energy-integrating CT or dual energy CT. However, achieving reliable and accurate…

Image and Video Processing · Electrical Eng. & Systems 2020-07-15 Bingqing Xie , Pei Niu , Ting Su , Valérie Kaftandjian , Loic Boussel , Philippe Douek Feng Yang , Philippe Duvauchelle , Yuemin Zhu

Material decomposition refers to using the energy dependence of material physical properties to differentiate materials in a sample, which is a very important application in computed tomography(CT). In propagation-based X-ray phase-contrast…

Medical Physics · Physics 2023-12-01 Suyu Liao , Huitao Zhang , Peng Zhang , Yining Zhu

This study presents a practical and dose-efficient strategy for resolution enhancement in planar radiography, based on mechanically supersampled acquisition with high-Z photon-counting detectors (PCDs). Unlike prior event-based or cluster…

Many clinical applications depend critically on the accurate differentiation and classification of different types of materials in patient anatomy. This work introduces a unified framework for accurate nonlinear material decomposition and…

Medical Physics · Physics 2018-03-19 Wei Zhao , Don Vernekohl , Fei Han , Bin Han , Hao Peng , Lei Xing , James K Min

Dual energy computed tomography (DECT) imaging plays an important role in advanced imaging applications due to its material decomposition capability. Image-domain decomposition operates directly on CT images using linear matrix inversion,…

Image and Video Processing · Electrical Eng. & Systems 2019-08-20 Zhipeng Li , Saiprasad Ravishankar , Yong Long , Jeffrey A. Fessler

Quantitative estimation of contrast agent concentration is made possible by spectral CT and material decomposition. There are several approaches to modulate the sensitivity of the imaging system to obtain the different spectral channels…

Medical Physics · Physics 2020-10-16 Matthew Tivnan , Wenying Wang , Grace Gang , Eleni Liapi , Peter Noel , J. Webster Stayman

Photon-counting computed tomography (PCCT) with energy discrimination capabilities hold great potentials to improve the limitations of the conventional CT, including better signal-to-noise ratio (SNR), improved contrast-to-noise ratio…

Medical Physics · Physics 2019-02-12 Xu Dong , Olga V. Pen , Zhicheng Zhang , Guohua Cao
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