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How to accurately predict the properties of molecules is an essential problem in AI-driven drug discovery, which generally requires a large amount of annotation for training deep learning models. Annotating molecules, however, is quite…

Machine Learning · Computer Science 2022-05-24 Kuangqi Zhou , Kaixin Wang , Jiashi Feng , Jian Tang , Tingyang Xu , Xinchao Wang

Several works in computer vision have demonstrated the effectiveness of active learning for adapting the recognition model when new unlabeled data becomes available. Most of these works consider that labels obtained from the annotator are…

Computer Vision and Pattern Recognition · Computer Science 2020-10-20 Sudipta Paul , Shivkumar Chandrasekaran , B. S. Manjunath , Amit K. Roy-Chowdhury

We improve upon pairwise annotation for active learning in coreference resolution, by asking annotators to identify mention antecedents if a presented mention pair is deemed not coreferent. This simple modification, when combined with a…

Computation and Language · Computer Science 2020-05-20 Belinda Z. Li , Gabriel Stanovsky , Luke Zettlemoyer

There is a broad range of BioNLP tasks for which active learning (AL) can significantly reduce annotation costs and a specific AL algorithm we have developed is particularly effective in reducing annotation costs for these tasks. We have…

Computation and Language · Computer Science 2014-09-16 Michael Bloodgood , K. Vijay-Shanker

Extracting MITRE ATT&CK techniques from cyber threat intelligence (CTI) reports is an open-set, multi-label problem requiring both high recall (not missing techniques) and high precision (not hallucinating unsupported ones). Existing…

Cryptography and Security · Computer Science 2026-05-26 Yutong Cheng , Changze Li , Raihan Sultan Pasha Basuki , Qian Cui , Wei Ding , Peng Gao

Self-supervised knowledge-graph completion (KGC) relies on estimating a scoring model over (entity, relation, entity)-tuples, for example, by embedding an initial knowledge graph. Prediction quality can be improved by calibrating the…

Machine Learning · Computer Science 2023-09-21 Anastasiia Sedova , Benjamin Roth

Repertoire-level analysis of T cell receptors offers a biologically grounded signal for disease detection and immune monitoring, yet practical deployment is impeded by label sparsity, cohort heterogeneity, and the computational burden of…

Machine Learning · Computer Science 2026-04-23 Rong Fu , Muge Qi , Yang Li , Yabin Jin , Jiekai Wu , Jiaxuan Lu , Chunlei Meng , Youjin Wang , Zeli Su , Juntao Gao , Li Bao , Qi Zhao , Wei Luo , Simon Fong

While pre-trained language model (PLM) fine-tuning has achieved strong performance in many NLP tasks, the fine-tuning stage can be still demanding in labeled data. Recent works have resorted to active fine-tuning to improve the label…

Computation and Language · Computer Science 2022-05-04 Yue Yu , Lingkai Kong , Jieyu Zhang , Rongzhi Zhang , Chao Zhang

The pretraining-finetuning paradigm has gained popularity in various computer vision tasks. In this paradigm, the emergence of active finetuning arises due to the abundance of large-scale data and costly annotation requirements. Active…

Computer Vision and Pattern Recognition · Computer Science 2024-02-28 Wenshuai Xu , Zhenghui Hu , Yu Lu , Jinzhou Meng , Qingjie Liu , Yunhong Wang

Accurate prediction of antibody-antigen binding affinity is fundamental to therapeutic design, yet remains constrained by severe label sparsity and the complexity of antigenic variations. In this paper, we propose AbLWR (Antibody-antigen…

Machine Learning · Computer Science 2026-04-14 Fan Xu , Zhi-an Huang , Haohuai He , Yidong Song , Wei Liu , Dongxu Zhang , Yao Hu , Kay Chen Tan

Objective: Electronic health record (EHR) phenotyping often relies on noisy proxy labels, which undermine the reliability of downstream risk prediction. Active learning can reduce annotation costs, but most rely on fixed heuristics and do…

Machine Learning · Computer Science 2025-11-25 Yang Yang , Kathryn I. Pollak , Bibhas Chakraborty , Molei Liu , Doudou Zhou , Chuan Hong

Entity Matching (EM) is a core data cleaning task, aiming to identify different mentions of the same real-world entity. Active learning is one way to address the challenge of scarce labeled data in practice, by dynamically collecting the…

Databases · Computer Science 2020-03-31 Venkata Vamsikrishna Meduri , Lucian Popa , Prithviraj Sen , Mohamed Sarwat

Crowdsourcing platforms offer a practical solution to the problem of affordably annotating large datasets for training supervised classifiers. Unfortunately, poor worker performance frequently threatens to compromise annotation reliability,…

Machine Learning · Computer Science 2014-01-17 Liyue Zhao , Yu Zhang , Gita Sukthankar

In this paper we propose an active metric learning method for clustering with pairwise constraints. The proposed method actively queries the label of informative instance pairs, while estimating underlying metrics by incorporating unlabeled…

Machine Learning · Statistics 2021-11-10 Yujia Deng , Yubai Yuan , Haoda Fu , Annie Qu

Medical research, particularly in predicting patient outcomes, heavily relies on medical time series data extracted from Electronic Health Records (EHR), which provide extensive information on patient histories. Despite rigorous…

Machine Learning · Computer Science 2025-06-04 Yuhao Li , Ling Luo , Uwe Aickelin

The efficacy of drug treatments depends on how tightly small molecules bind to their target proteins. The rapid and accurate quantification of the strength of these interactions (as measured by binding affinity) is a grand challenge of…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-10-30 Jumana Dakka , Kristof Farkas-Pall , Matteo Turilli , David W Wright , Peter V Coveney , Shantenu Jha

Cell detection in histopathology images is of great interest to clinical practice and research, and convolutional neural networks (CNNs) have achieved remarkable cell detection results. Typically, to train CNN-based cell detection models,…

Computer Vision and Pattern Recognition · Computer Science 2023-02-17 Zipei Zhao , Fengqian Pang , Yaou Liu , Zhiwen Liu , Chuyang Ye

Vision-Language Models (VLMs), such as CLIP, have achieved impressive zero-shot recognition performance but remain highly susceptible to adversarial perturbations, posing significant risks in safety-critical scenarios. Previous…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Zhiwei Li , Yitian Pang , Weining Wang , Zhenan Sun , Qi Li

Image annotation for active learning is labor-intensive. Various automatic and semi-automatic labeling methods are proposed to save the labeling cost, but a reduction in the number of labeled instances does not guarantee a reduction in cost…

Machine Learning · Computer Science 2020-02-10 Yingcheng Sun , Kenneth Loparo

Deep learning-based diagnostic models often suffer performance drops due to distribution shifts between training (source) and test (target) domains. Collecting and labeling sufficient target domain data for model retraining represents an…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Yaofei Duan , Yuhao Huang , Xin Yang , Luyi Han , Xinyu Xie , Zhiyuan Zhu , Ping He , Ka-Hou Chan , Ligang Cui , Sio-Kei Im , Dong Ni , Tao Tan