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The widespread adoption of effective hybrid closed loop systems would represent an important milestone of care for people living with type 1 diabetes (T1D). These devices typically utilise simple control algorithms to select the optimal…

Machine Learning · Computer Science 2023-05-08 Harry Emerson , Matthew Guy , Ryan McConville

People with type 1 diabetes (T1D) lack the ability to produce the insulin their bodies need. As a result, they must continually make decisions about how much insulin to self-administer to adequately control their blood glucose levels.…

Machine Learning · Computer Science 2020-09-22 Ian Fox , Joyce Lee , Rodica Pop-Busui , Jenna Wiens

End-to-end (E2E) autonomous driving models that take only camera images as input and directly predict a future trajectory are appealing for their computational efficiency and potential for improved generalization via unified optimization;…

Robotics · Computer Science 2026-04-10 Chihiro Noguchi , Takaki Yamamoto

There is increasing interest in data-driven approaches for recommending optimal treatment strategies in many chronic disease management and critical care applications. Reinforcement learning methods are well-suited to this sequential…

Machine Learning · Computer Science 2023-06-14 Milashini Nambiar , Supriyo Ghosh , Priscilla Ong , Yu En Chan , Yong Mong Bee , Pavitra Krishnaswamy

In this paper we investigate the use of model-based reinforcement learning to assist people with Type 1 Diabetes with insulin dose decisions. The proposed architecture consists of multiple Echo State Networks to predict blood glucose levels…

This paper presents a novel multi-agent reinforcement learning (RL) approach for personalized glucose control in individuals with type 1 diabetes (T1D). The method employs a closed-loop system consisting of a blood glucose (BG) metabolic…

Machine Learning · Computer Science 2023-07-24 Mehrad Jaloli , Marzia Cescon

Reinforcement learning (RL) has demonstrated success in automating insulin dosing in simulated type 1 diabetes (T1D) patients but is currently unable to incorporate patient expertise and preference. This work introduces PAINT (Preference…

Artificial Intelligence · Computer Science 2025-01-28 Harry Emerson , Sam Gordon James , Matthew Guy , Ryan McConville

In this paper, a novel robust tracking control scheme for a general class of discrete-time nonlinear systems affected by unknown bounded uncertainty is presented. By solving a parameterized optimal tracking control problem subject to the…

Systems and Control · Electrical Eng. & Systems 2023-12-08 Alexandros Tanzanakis , John Lygeros

Comorbid chronic conditions are common among people with type 2 diabetes. We developed an Artificial Intelligence algorithm, based on Reinforcement Learning (RL), for personalized diabetes and multi-morbidity management with strong…

Computers and Society · Computer Science 2020-11-05 Hua Zheng , Ilya O. Ryzhov , Wei Xie , Judy Zhong

This paper proposes a robust control design method using reinforcement-learning for controlling partially-unknown dynamical systems under uncertain conditions. The method extends the optimal reinforcement-learning algorithm with a new…

Systems and Control · Electrical Eng. & Systems 2020-04-17 Phuong D. Ngo , Fred Godtliebsen

Managing physiological variables within clinically safe target zones is a central challenge in healthcare, particularly for chronic conditions such as Type 1 Diabetes Mellitus (T1DM). Reinforcement learning (RL) offers promise for…

Machine Learning · Computer Science 2025-08-07 David H. Mguni , Jing Dong , Wanrong Yang , Ziquan Liu , Muhammad Salman Haleem , Baoxiang Wang

Reinforcement learning (RL) is a type of artificial intelligence for making optimal choices. In healthcare, researchers generally use offline RL (ORL), where models are trained and evaluated from retrospective observational data. To…

Machine Learning · Computer Science 2026-04-30 Thomas Frost , Hrisheekesh Vaidya , Steve Harris

People with Type 1 diabetes (T1D) require regular exogenous infusion of insulin to maintain their blood glucose concentration in a therapeutically adequate target range. Although the artificial pancreas and continuous glucose monitoring…

Signal Processing · Electrical Eng. & Systems 2020-09-08 Taiyu Zhu , Kezhi Li , Pau Herrero , Pantelis Georgiou

Offline reinforcement learning (RL) provides a promising approach to avoid costly online interaction with the real environment. However, the performance of offline RL highly depends on the quality of the datasets, which may cause…

Robotics · Computer Science 2024-05-08 Yiwen Hou , Haoyuan Sun , Jinming Ma , Feng Wu

We propose a virtual clinical trial for assessing the safety and efficacy of closed-loop diabetes treatments prior to an actual clinical trial. Such virtual trials enable rapid and risk-free pretrial testing of algorithms, and they can be…

Optimization and Control · Mathematics 2022-05-04 Tobias K. S. Ritschel , Asbjørn Thode Reenberg , John Bagterp Jørgensen

Modern decision-making systems, from robots to web recommendation engines, are expected to adapt: to user preferences, changing circumstances or even new tasks. Yet, it is still uncommon to deploy a dynamically learning agent (rather than a…

Machine Learning · Computer Science 2022-11-15 Shengpu Tang , Felipe Vieira Frujeri , Dipendra Misra , Alex Lamb , John Langford , Paul Mineiro , Sebastian Kochman

Type 1 Diabetes (T1D) management requires continuous adjustment of insulin and lifestyle behaviors to maintain blood glucose within a safe target range. Although automated insulin delivery (AID) systems have improved glycemic outcomes, many…

Effective management of Type 1 Diabetes requires continuous glucose monitoring and precise insulin adjustments to prevent hyperglycemia and hypoglycemia. With the growing adoption of wearable glucose monitors and mobile health applications,…

Machine Learning · Computer Science 2026-01-22 Giorgia Rigamonti , Mirko Paolo Barbato , Davide Marelli , Paolo Napoletano

Patients with diabetes who are self-monitoring have to decide right before each meal how much insulin they should take. A standard bolus advisor exists, but has never actually been proven to be optimal in any sense. We challenged this rule…

Machine Learning · Statistics 2020-07-24 Frédéric Logé , Erwan Le Pennec , Habiboulaye Amadou-Boubacar

End-to-end learning robotic manipulation with high data efficiency is one of the key challenges in robotics. The latest methods that utilize human demonstration data and unsupervised representation learning has proven to be a promising…

Robotics · Computer Science 2021-10-22 Jin Li , Xianyuan Zhan , Zixu Xiao , Guyue Zhou
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